Development and characterization of alginate microcapsules containing Bifidobacterium BB-12 produced by emulsification/internal gelation followed by freeze drying

Holkem, Augusto Tasch; Raddatz, Greice Carine; Nunes, Guilherme S.; Cichoski, Alexandre José; Jacob‐Lopes, Eduardo; Grosso, Carlos Raimundo Ferreira; Menezes, Cristiano Ragagnin de

doi:10.1016/j.lwt.2016.04.012

Cited by 86 publications

(45 citation statements)

References 50 publications

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“…These results are in agreement with those publised by Holkem et al (2016) who found % EE values of 89.71% for Bifidobacterium BB-12 microencapsulated by IIG using alginate as a wall material. Likewise, Pitigraisorn et al (2017) reported % EE values of 95.3% for L. acidophilus microencapsulated on non coated alginate beads.…”

Section: Characterization Of Microcapsules Loaded With L Acidophilussupporting

confidence: 93%

“…The microcapsules had an average diameter of 102.82 µm being higher than those reported by Holkem et al (2016) who reported mean diameters of 77.84 µm on microcapsules based on alginate. In the present study, smaller diameters were obtained than those obtained by Cai et al (2014), who microencapsulated L. acidophilus with alginate by emulsification obtaining microcapsules with mean sizes ranging from 323 to 343 mm.…”

Section: Characterization Of Microcapsules Loaded With L Acidophiluscontrasting

confidence: 64%

“…All these effects are caused by inhibiting pathogen growth and stimulating the host's immune response (Figueroa et al, 2011). However, the incorporation and viability of these bacteria in food products still represent a technological challenge for researchers during the development of new probiotic products, because the viability of probiotics often decreases sharply during gastric transit due to the strong acidic conditions (Holkem et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Protection of Lactobacillus acidophilus under in vitro gastrointestinal conditions employing binary microcapsules containing inulin

González-Cuello¹,

Colpas-Castillo²,

Taron-Dunoyer³

2017

Afr. J. Biotechnol.

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In this research, microcapsules based on low acyl gellan (LAG) and sodium alginate (SA) containing inulin were developed in order to assess its protective effect on the viability of Lactobacillus acidophilus under in vitro gastrointestinal conditions.The results showed that microencapsulated cells display significantly (P<0.05) higher resistance to simulated gastrointestinal conditions (SGIC) than free cells. Besides, the incorporation of inulin into the wall matrix resulted in improved survival after 5 h incubation in SGIC. These results represent an alternative to vehiculate probiotics in food, especially in solid food due to the size of the microcapsules. Therefore, these microcapsules can contribute to possible industrial applications in the development of new alimentary products.

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Section: Characterization Of Microcapsules Loaded With L Acidophilussupporting

confidence: 93%

Section: Characterization Of Microcapsules Loaded With L Acidophiluscontrasting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protection of Lactobacillus acidophilus under in vitro gastrointestinal conditions employing binary microcapsules containing inulin

González-Cuello¹,

Colpas-Castillo²,

Taron-Dunoyer³

2017

Afr. J. Biotechnol.

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“…This result was lower than Holkem et al, [31], where the EE of alginate microcapsules with freeze drying method was 89,71%. According to Karthik and Anandharamakrishnan [32], an active compound which encapsulated using freeze drying method could produce porous microcapsule on its surface because there is ice sublimation during the drying process.…”

Section: Encapsulation Efficiency (Ee)contrasting

confidence: 61%

Physical characteristics of phycocyanin from spirulina microcapsules using different coating materials with freeze drying method

Dewi

Purnamayati

Kurniasih

2017

IOP Conf. Ser.: Earth Environ. Sci.

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:The aim of this study was to compare the physical characteristics of phycocyanin microcapsules (F) from Spirulina sp. with different coating materials, such as κ-Carrageenan (C) and Na-alginate (A) in combination with maltodextrin (M) by freeze drying method. Microcapsules were prepared in three variations of coating materials i.e. maltodextrin (FM); maltodextrin and Na-alginate (FMA); and maltodextrin and carrageenan (FMC) with concentration of each materials were 10%; 9%:1.0%; and 9%:1% (w/w), respectively. The results showed that FMA with Na-alginate 1.0% produced the highest bulk density and total soluble solid, there were 0,334 g/ml and 9,067%, respectively. Color analysis by chromameter showed that FMC produced the bluest color compared to other samples. The glass transition temperature (Tg) investigated with Differential scanning calorimeter (DSC) in all of the samples.

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“…Encapsulation of probiotics into alginate microgels has also been used to coadminister probiotics and antibiotics in order to prevent antimicrobial resistance of pathogens (Li et al., ). Alginate microgels containing B. BB ‐12 was produced by emulsification/internal gelation followed by freeze drying for achieving better protection and controlled release of probiotics (Holkem et al., ; Holkem et al., ). Although alginate is probably the most widely used biopolymer to fabricate microgels, other biopolymers can also be used.…”

Section: Microencapsulation Of Probioticsmentioning

confidence: 99%

Progress in microencapsulation of probiotics: A review

Yao

Xie

et al. 2020

Comp Rev Food Sci Food Safe

325

160

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The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation can be used to enhance the resistance of probiotics to unfavorable conditions. A range of oral delivery systems has been developed to increase the level of probiotics reaching the colon including embedding and coating systems. This review introduces emerging strategies for the microencapsulation of probiotics and highlights the key mechanisms of their stress–tolerance properties. Recent in vitro and in vivo models for evaluation of the efficiency of probiotic delivery systems are also reviewed. Encapsulation technologies are required to maintain the viability of probiotics during storage and within the human gut so as to increase their ability to colonize the colon. These technologies work by protecting the probiotics from harsh environmental conditions, as well as increasing their mucoadhesive properties. Typically, the probiotics are either embedded inside or coated with food‐grade materials such as biopolymers or lipids. In some cases, additional components may be coencapsulated to enhance their viability such as nutrients or protective agents. The importance of having suitable in vitro and in vivo models to evaluate the efficiency of probiotic delivery systems is also emphasized.

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Development and characterization of alginate microcapsules containing Bifidobacterium BB-12 produced by emulsification/internal gelation followed by freeze drying

Cited by 86 publications

References 50 publications

Protection of Lactobacillus acidophilus under in vitro gastrointestinal conditions employing binary microcapsules containing inulin

Protection of Lactobacillus acidophilus under in vitro gastrointestinal conditions employing binary microcapsules containing inulin

Physical characteristics of phycocyanin from spirulina microcapsules using different coating materials with freeze drying method

Progress in microencapsulation of probiotics: A review

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