Development and characterization of bacterial nanocellulose loaded with Boswellia serrata extract containing nanoemulsions as natural dressing for skin diseases

Karl, Berit; Alkhatib, Yaser; Beekmann, Uwe; Bellmann, Tom; Blume, G.; Steiniger, Frank; Thamm, Jana; Werz, Oliver; Kralisch, Dana; Fischer, Dagmar

doi:10.1016/j.ijpharm.2020.119635

Cited by 24 publications

(24 citation statements)

References 58 publications

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“…To transfer these findings to boswellic acid incorporation, loading experiments with the most promising post -modification (esterification) compared to native BC and lipophilic extracts of the gum resin derived from Boswellia serrata (“Frankincense”, B. serrata extracts, BSE) were carried out. Initial findings showed that AcBC, as in the model studies, can improve the loading efficiency of lipophilic compounds such as KBA (log P = 7.10) and AKBA (log P = 8.44) in a similar way as nanoemulsions [ 19 ]). However, the first Franz cell release experiments with native BC and AcBC samples loaded with these lead compounds have revealed a lower cumulative release of ABKA and KBA (data not shown) compared to a formulation in nanoemulsions [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…Initial findings showed that AcBC, as in the model studies, can improve the loading efficiency of lipophilic compounds such as KBA (log P = 7.10) and AKBA (log P = 8.44) in a similar way as nanoemulsions [ 19 ]). However, the first Franz cell release experiments with native BC and AcBC samples loaded with these lead compounds have revealed a lower cumulative release of ABKA and KBA (data not shown) compared to a formulation in nanoemulsions [ 19 ]. Further studies are therefore needed to investigate the mechanisms behind release vs. retaining of highly lipophilic drugs within the (modified) BC carrier material prior further optimization of post -modification strategies.…”

Section: Resultsmentioning

confidence: 99%

“…Instead, the effect of the modifications on the loading and release behavior in relation to native BC was compared. Studies with lipophilic extracts of the gum resin derived from Boswellia serrata ( B. serrata extracts, BSE) were performed according to previous investigations [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

“…Paraffin gauze Jelonet ® , occlusive dressing Opsite ® Flexifix and gauze bandage Ypsiflex ® were used. The further procedure of the experiment was analogous to previous Franz cell experiments [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

“…We suggest a natural product concept combining the unique properties of the natural biopolymer BC with the highly effective anti-inflammatory natural substance AKBA. Although the incorporation of lipophilic APIs into BC is still challenging, the hydrophilic characteristic of BC can be overcome by utilizing auxiliary excipients, additives or emulsions [ 19 , 20 ]. Alternatively, modifying the carrier material itself can facilitate the incorporation of lipophilic APIs [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds

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Natural products suited for prophylaxis and therapy of inflammatory diseases have gained increasing importance. These compounds could be beneficially integrated into bacterial cellulose (BC), which is a natural hydropolymer applicable as a wound dressing and drug delivery system alike. This study presents experimental outcomes for a natural anti-inflammatory product concept of boswellic acids from frankincense formulated in BC. Using esterification respectively (resp.) oxidation and subsequent coupling with phenylalanine and tryptophan, post-modification of BC was tested to facilitate lipophilic active pharmaceutical ingredient (API) incorporation. Diclofenac sodium and indomethacin were used as anti-inflammatory model drugs before the findings were transferred to boswellic acids. By acetylation of BC fibers, the loading efficiency for the more lipophilic API indomethacin and the release was increased by up to 65.6% and 25%, respectively, while no significant differences in loading could be found for the API diclofenac sodium. Post-modifications could be made while preserving biocompatibility, essential wound dressing properties and anti-inflammatory efficacy. Eventually, in vitro wound closure experiments and evaluations of the effect of secondary dressings completed the study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds

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Nanocellulose: Recent Advances Toward Biomedical Applications

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Sustainable materials are key to the continual improvement of living standards on this planet with minimal environmental impacts. Nanocellulose combines the fascinating features of nanomaterials with favorable properties of the abundantly available cellulose biopolymer, which in recent years has gained much attention toward biomedical applications by virtue of its unique surface chemistry, remarkable physical features, and inherent biological attributes. Herein, the recent advances in nanocellulose‐based biomedical materials, with foci on biomolecule immobilization, drug delivery, cell culture and tissue engineering (TE), antimicrobial strategy, wound healing, and biomedical implants are summarized. Each topic is elaborated with representative examples to present the significance of nanocelluloses in their respective material design principles utilizing different sub‐types, including cellulose nanofibers (CNFs), cellulose nanocrystals (CNCs), and bacterial nanocellulose (BNC). The current state of large‐scale production of nanocellulose and accelerated development by artificial intelligence and machine learning are also briefly discussed, before ending with its future prospects and potential challenges.

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Bacterial Cellulose Nanofibers

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Cellulose is among the world's wealthiest biopolymers and primarily has a wood, plant, and microbial source. To date, cellulose nanofibers (CNFs) are synthesized under controlled conditions (temperature, pH, and agitation). The bacterial synthesis of CNFs, so-called bacterial cellulose (BC), has become actively interested in recent times. These emerged natural biopolymers have excellent hydrophilicity, biodegradability, renewability, and mechanical properties. The nanoscale dimension of the synthesized cellulose provides a sizeable functional surface area, low weight and density, and a high-interconnected pore system. Based on these properties, bacterial cellulose nanofibers open a broad range of environmental applications as biosorbents, ultrafiltration membrane, as well as a bio-reducing agent for the biosynthesis of nanoparticles with high photocatalytic activity. Moreover, these nanofibers prove their complete applications in the biomedical, textile, food, and cosmetic industries. The present chapter is devoted to investigating the mechanism of bacterial cellulose nanofibers biosynthesis, functionalization, and its area of applications.

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Development and characterization of bacterial nanocellulose loaded with Boswellia serrata extract containing nanoemulsions as natural dressing for skin diseases

Cited by 24 publications

References 58 publications

Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds

Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds

Nanocellulose: Recent Advances Toward Biomedical Applications

Bacterial Cellulose Nanofibers

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