Development and Characterization of Biocompatible Mannose Functionalized Mesospheres: an Effective Chemotherapeutic Approach for Lung Cancer Targeting

Gautam, Laxmikant; Sharma, Rajeev; Shrivastava, Priya; Vyas, Sonal; Vyas, Suresh P.

doi:10.1208/s12249-020-01742-9

Cited by 17 publications

(4 citation statements)

References 36 publications

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“… 13 Recently, mannose was reported to be effective against lung cancer, breast cancer, and osteosarcoma. 28 , 29 , 30 , 31 , 32 Low expression of PMI makes cells more sensitive to the antitumor effect of mannose, and all of these cancers express low levels of PMI. By contrast, leukemia cells express PMI, but it remains unclear how mannose metabolism contributes to their survival and proliferation.…”

Section: Discussionmentioning

confidence: 99%

Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia

et al. 2021

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Leukemia cell proliferation requires activation and reprogramming of metabolic pathways to supply anabolic cell growth. This aberrant cancer metabolism was first recognized by Warburg, 1 who postulated that cancer tissues have a higher rate of glucose uptake and glycolysis compared with normal tissues and rely primarily on glucose to produce ATP with or without oxygen. Oncogenic driver genes regulate metabolic pathways such as MYC and RAS, which drive metabolic reprogramming in leukemia. Elevated MYC expression is a hallmark of Burkitt's lymphoma and acute lymphoblastic leukemias (ALL). Aberrant activation of MYC leads to increased glucose uptake and glycolytic activity, glutaminolysis, and lipid synthesis. [2][3][4][5] Activating mutations in the RAS pathway are characteristic of

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Section: Discussionmentioning

confidence: 99%

Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia

et al. 2021

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“…Since protein–carbohydrate interactions are mediated via lectin receptors, which are overexpressed on the surface of neoplastic cells, this interaction could be used in targeted chemotherapy, as was reported for gelatin mannosylated-Dox-mesospheres [ 26 ]. It was also observed that the interaction between Dox and hemoglobin is influenced by the presence and concentration of glucose [ 27 ] reducing the binding affinity of Dox to hemoglobin by allosteric effect, and suppressing the impact of Dox on hemoglobin structure.…”

Section: Introductionmentioning

confidence: 99%

Functionalized Mesoporous Silica as Doxorubicin Carriers and Cytotoxicity Boosters

Racleş¹,

Zaltariov²,

Peptanariu³

et al. 2022

Nanomaterials

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Mesoporous silica nanoparticles (MSNs) bearing methyl, thiol or glucose groups were synthesized, and their encapsulation and release behaviors for the anticancer drug Doxorubicin (Dox) were investigated in comparison with nonporous homologous materials. The chemical modification of thiol-functional silica with a double bond glucoside was completed for the first time, by green thiol-ene photoaddition. The MSNs were characterized in terms of structure (FT-IR, Raman), morphology (TEM), porosity (nitrogen sorption–desorption) and Zeta potential measurements. The physical interactions responsible for the Dox encapsulation were investigated by analytic methods and MD simulations, and were correlated with the high loading efficiency of MSNs with thiol and glucose groups. High release at pH 5 was observed in most cases, with thiol-MSN exhibiting 98.25% cumulative release in sustained profile. At pH 7.4, the glucose-MSN showed 75.4% cumulative release, while the methyl-MSN exhibited a sustained release trend. The in vitro cytotoxicity was evaluated on NDHF, MeWo and HeLa cell lines by CellTiter-Glo assay, revealing strong cytotoxic effects in all of the loaded silica at low equivalent Dox concentration and selectivity for cancer cells. Atypical applications of each MSN as intravaginal, topical or oral Dox administration route could be proposed.

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“…The cancer cell generates its environment for its growth which includes excess cell proliferation, low pH, hypoxia, formation of neo-blood vessels (neoangiogenesis), high temperature, high enzymatic activity, etc. Different nanotechnological drug delivery system(s) including liposomes, 4 vesosomes, 5 nanoparticles, 6 mesospheres, 7 nanosponges, 8 superparamagnetic iron oxide nanoparticles (SPIONs), quantum dots 9 , etc., have been explored as the delivery…”

Section: Introductionmentioning

confidence: 99%

Site-Specific Delivery of Doxorubicin Using Cell-Penetrating Peptide for Lung Cancer Chemotherapy

Gautam

Vyas

2022

Int J. Pharm. Investigation

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platform for bioactive(s) i.e., doxorubicin, paclitaxel, cisplatin, methotrexate, etc. These drugs could be targeted to the site of action using nanomodules resulting in an improved therapeutic index. DOX is an anthracycline antibiotic used to treat leukemia, lung cancer, breast cancer, and ovarian malignancies. DOX mechanisms as an anticancer agent are as follows: (i) production of free radicals and the resulting impairment of cellular membranes, proteins, and DNA; and (ii) interaction with DNA and disruption of topoisomerase-II-mediated DNA repair. Semiquinone, an unstable metabolite that is produced from DOX in a process that produces reactive oxygen species, is formed when DOX is oxidized. This process causes DNA damage, oxidative stress, and the activation of apoptotic pathways in cells. 10 For a site-specific delivery, the ligand is selected which directly targets the cancer site and inhibits the cancer cell growth, with subsequent programmed cell death. The CAR-peptide 11,12 which is a cell-penetrating peptide was selected for the delivery of DOX-loaded liposomes. CAR peptide is a nonapeptide having a series of 9-amino acid CARSKNKDC 13,14 specifically binds with the heparan sulfate receptor over-expressed on the cancer cells of lung carcinomas and reportedly also inhibits the neoangiogenesis by binding in a site-specific manner.

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Development and Characterization of Biocompatible Mannose Functionalized Mesospheres: an Effective Chemotherapeutic Approach for Lung Cancer Targeting

Cited by 17 publications

References 36 publications

Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia

Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia

Functionalized Mesoporous Silica as Doxorubicin Carriers and Cytotoxicity Boosters

Site-Specific Delivery of Doxorubicin Using Cell-Penetrating Peptide for Lung Cancer Chemotherapy

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