2023
DOI: 10.1101/2023.09.08.556876
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Development and Characterization of Co-crystals Assisted withIn-silicoScreening for Solubility and Permeability Enhancement of Curcumin

Meera Singh,
Shweta Takawale,
Rajesh Patil
et al.

Abstract: Despite being a promising phytochemical, Curcumin’s potential applications are limited due to its classification in BCS class IV, which is associated with low water solubility and permeability. Enhancing the bioavailability of BCS class IV drugs presents a significant challenge, but crystal chemistry provides a hopeful avenue for overcoming this hurdle. In this research, co-crystals of Curcumin were developed to improve both solubility and permeability. Unlike traditional methods that require extensive trial-b… Show more

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