Development and Characterization of Drug Loaded PVA/PCL Fibres for Wound Dressing Applications

Abstract

Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, are the need of the time. The main aim of this study was to develop and characterize polyvinyl alcohol/polycaprolactone (PVA/PCL) fibres containing a model drug. A dope solution comprising PVA/PCL with the drug was extruded into a coagulation bath and became solidified. The developed PVA/PCL fibres were then rinsed and dried. These fibres were tested for Fourier transform infrared spectroscopy, linear density, topographic analysis, tensile properties, liquid absorption, swelling behaviour, degradation, antimicrobial activity, and drug release profile for improved and better healing of the wound. From the results, it was concluded that PVA/PCL fibres containing a model drug can be produced by using the wet spinning technique and have respectable tensile properties; adequate liquid absorption, swelling %, and degradation %; and good antimicrobial activity with the controlled drug release profile of the model drug for wound dressing applications.

AgNPs/g-C3N4/PVA antibacterial hydrogel with excellent photocatalytic antibacterial activity for wound dressing

“…41 For PVA, the signals at 3100–3600 cm −1 were attributed to –OH bending vibration, the peak at 2938 cm −1 was ascribed to C–H stretching vibration, and the peaks at 1640 cm −1 and 1035 cm −1 were assigned to CO and C–O, respectively. 1,10 The distinctive peaks of AgNPs/g-C 3 N 4 /PVA resembled those of PVA, possibly due to the hydrogel's low AgNPs/g-C 3 N 4 content.…”

“…Skin is the biggest organ in the human body, it protects the internal structures and acts as a barrier against exterior pathogens. 1,2 However, human skin is susceptible to various wounds, such as burns, scalds, and diabetic ulcers. Skin injuries are often accompanied by bacterial infections, which can cause a series of problems, including uncontrolled bleeding, delayed healing, increasing morbidity and mortality, and even threaten patients' lives if not handled properly.…”

Fabrication and evaluation of a bi-layered electrospun PCL/PVA patch for wound healing: Release of vitamins and silver nanoparticle

“…The mechanical characteristics of PCL/PVA wound dressings have been studied. Due to its excellent mechanical characteristics, absorption, swelling, and degradation, PVA has been employed in past investigations for medical applications [ 40 ]. An active wound dressing should have ideal water absorption, acceptable flexibility, and adequate mechanical qualities [ 22 ].…”

Thermo-Responsive Hydrogels Encapsulating Targeted Core–Shell Nanoparticles as Injectable Drug Delivery Systems

“…However, obtaining precise control over the pore size and biodegradation of hydrogel networks might emerge as a serious issue in obtaining controlled release profiles in the presence of a recurring and metastatic cancer type like ovarian cancer or glioma [ 12 , 13 , 14 , 15 , 16 ]. In particular, natural and hydrophilic pH-responsive polymers, such as alginate, chitosan, and gelatin, were shown to liberate internally loaded active agents more rapidly due to their high degradation rate in tumor environments [ 17 , 18 , 19 ] compared to polyanhydride- and polyester-based synthetic polymers (i.e., poly(glycolide-co-sebacate) (PGS), poly (caprolactone) (PCL), and poly (lactide-co-glycolide) (PLGA)) [ 20 , 21 , 22 , 23 , 24 ]. Thus, an urgent need has evolved for hydrogels with tunable properties for the slower and sustained release of therapeutic agents.…”