Development and characterization of Eudragit based mucoadhesive buccal patches of salbutamol sulfate

Abstract

For systemic drug delivery, the buccal region offers an attractive route of drug administration. Salbutamol sulfate is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease. It's oral bioavailability is ∼40% due to extensive first pass metabolism. Salbutamol sulfate patches were prepared using Eudragit L-100, HPMC, PVA and Carbopol 934 in various proportions and combinations using PEG-400/PG as plasticizers. Patches were laminated on one side with a water impermeable backing layer for unidirectional drug release. The thickness of medicated patches were ranged between 0.23 ± 0.008 and 0.59 ± 0.007 mm and mass varied between 65.23 ± 3.3 and 117.92 ± 4.2 mg. Patches showed an increase in mass and swelling index with PEG-400 when compared with PG. The surface-pH of patches ranged between 6 and 7. Formulations E7 (7.5 mL Eudragit L-100, 15 mL HPMC K4M, 7.5 mL PVA and 2 mL PEG-400), E12 (7.5 mL Eudragit L-100, 7.5 mL PVA, 15 mL Carbopol and 2 mL PEG-400), F7 (7.5 mL Eudragit L-100, 15 mL HPMC K4M, 7.5 mL PVA and 2 mL PG), and F12 (7.5 mL Eudragit L-100, 7.5 mL PVA, 15 mL Carbopol and 2 mL PG) showed high folding endurance. Residence time of the tested patches ranged between 101 and 110 min. The maximum in vitro release was found to be 99.93% over a period of 120 min for formulation F12. Data of in vitro release from patches were fitted to different kinetic models such as Higuchi and Korsmeyer-Peppas models to explain the release profile. Formulations E7 and F7 were best fitted to the non-Fickian, where as formulations E12 and F12 showed Fickian/anomalous drug release. Stability studies indicated that there was no change in the chemical and physical characteristics during the test period.

Cellulose Buccoadhesive Film Bearing Glimepiride: Physicomechanical Characterization and Biophysics of Buccoadhesion

“…Experimental evidences on better therapeutic efficacy of drug molecules viz. carvedilol, lidocaine, salbutamol, and miconazole as buccoadhesive films/patches have been referenced in scientific texts (2,3). Moreover, mucoadhesive preparations included in the European Pharmacopoeia 7.4 (2012) have encouraged researchers to utilize the advantages of the technique in drug delivery research (4).…”

Preparation, Characterization and Optimization of Thiopectin Based Mucoadhesive Microspheres of Salbutamol Sulphate

“…After this add glutaraldehyde (3 ml) and kept this mixture under magnetic stirrer at 1000 rpm for 18 hours at 40 0 C. Prepared microspheres were isolated by centrifugation and washed twice with cyclohexane and distilled water. Microspheres were dried under desiccators 16 .…”

A Review on Candidiasis resistance current drug development process in its prevention and treatment

“…By using solvent Castin method mucoadhesive oral strips were prepared, for this EUD RS-100, EUD RL-100, HPMC K100M, and HPMC E50 are used as a polymer which is a very speci ic and sensitive polymer, and it is also a safe one to use and which is also helpful for the controlled release of the drug. (Vasantha et al, 2011).…”