Development and characterization of matrix-type drug delivery system for the treatment of Overactive Bladder

de Mello Gindri, Izabelle; Ferrari, Gustavo; da Silva, Loise Silveira; Salmoria, Gean Vitor; de Mello Roesler, Carlos Rodrigo

doi:10.1007/s00289-024-05394-8

Polym. Bull.

2024

DOI: 10.1007/s00289-024-05394-8

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Development and characterization of matrix-type drug delivery system for the treatment of Overactive Bladder

Izabelle de Mello Gindri,

Gustavo Ferrari,

Loise Silveira da Silva

et al.

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2024

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3D printing of intrauterine device loaded with silver sulfadiazine to the treatment of fungal diseases

Ferrari,

Silva,

Batistella

et al. 2024

Preprint

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Purpose: The main goal of the present study is to develop and manufacture drug delivery devices for fungal treatment concerning women's health attention. Methods: Ethylene Vinyl Acetate (EVA) and Thermoplastic Polyurethane TPU were manufactured by hot melt extrusion (HME) and fused-deposition modeling (FDM™). Drug loaded prototypes were manufactured combining EVA and TPU matrices with silver sulfadiazine (AgSD). Results: EVA and TPU were loaded with 10 and 20% theoretical drug load resulting in desired intrauterine device geometries. The devices' physicochemical, mechanical properties and in-vitro drug release were characterized. Drug release presented a burst release due to surface agglomerates of AgSD and controlled release after this initial behavior. Conclusion: The HME were successfully used to produce polymeric filaments and to incorporate the drug into the polymeric matrix. The EVA and TPU devices were released for 30 days, showing promising results for the local delivery systems.

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3D printing of intrauterine device loaded with silver sulfadiazine to the treatment of fungal diseases

Ferrari,

Silva,

Batistella

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Development and characterization of matrix-type drug delivery system for the treatment of Overactive Bladder

Cited by 1 publication

References 14 publications

3D printing of intrauterine device loaded with silver sulfadiazine to the treatment of fungal diseases

3D printing of intrauterine device loaded with silver sulfadiazine to the treatment of fungal diseases

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