Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery

Abstract

Buccal patches of salbutamol sulfate were prepared using five different water soluble polymers in various proportions and combinations using PEG-400/PG as plasticizers. A 32 full factorial design was used to design the experiments for each polymer combination. Patches were laminated on one side with a water impermeable backing layer for unidirectional drug release. The thickness of medicated patches ranged between 0.2 and 0.4 mm and showed an increase in mass whenever PEG-400 was used as plasticizer. The surface pH of all patches approached neutral. Eight formulations which had shown high folding endurance (> 300) were selected for evaluation. Patches prepared with PEG-400 showed a high swelling index. The residence time of the tested patches ranged between 105 and 130 min. Formulations A10, A32, B10 and B32 fitted the Higuchi model best, whereas formulations A19 and B19 showed super case II transport drug release. Stability studies indicated that there was no change in the chemical and physical characteristics during the test period of 6 months.

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis

“…53 However, in another study, Garg et al 54 proposed that the extent of mucoadhesive strength will directly reflect the residence time of the dosage form in the target site.…”

Formulation and Evaluation of Levofloxacin-Chitosan / Β- Cyclodextrin Nanoparticles by Ionic Gelation

“…After appropriate dilution the samples were assayed at 287 nm. The mechanism of drug release from the nanoparticles was determined by finding Higuchi and Korsmeyer-Peppas plots [16][17][18][19] .…”

Formulation of unidirectional release buccal patches of carbamazepine and study of permeation through porcine buccal mucosa

“…Patches were then allowed to dry at room temperature for 2 h and further dried in a hot air oven at 40 °C for 48 h. The dried patches were carefully examined for imperfections or entrapped air bubbles and cut into 3 cm diameter patches equivalent to 20 mg of carbamazepine. The patches were affixed on one side with a water impermeable backing layer (Pidilite® Biaxiallyoriented polypropylene film) to provide unidirectional drug release and packed in an aluminium foil to store in a desiccator at room temperature for further studies [7] . Mass uniformity and thickness of prepared buccal patches (without backing layer) were measured using a digital balance and a digital vernier caliper respectively.…”