Development and characterization of Novel topical oil/PEG creams of voriconazole for the treatment of fungal infections

Hot melt extrusion (HME) technology was introduced to pharmaceuticals in the 1970s for manufacturing and product development. Since then, there were several developments in HME technology to utilize it effectively for the manufacturing of pharmaceuticals. Though the primary purpose of HME technology remains to be solubility enhancement through the preparation of amorphous solid dispersions, it also has various other applications like dry granulation, abuse-deterrent formulation, continuous manufacturing, film preparation, implants, sustained release formulations, etc. The purpose of this review article is to consolidate the information related to applications of HME technology in the pharmaceutical industry. Keywords: Hot melt extrusion, poorly soluble drugs, continuous manufacturing, solid orals, and applications.

“…Transcutol P and a combination of camphor and menthol were studied as permeation enhancers. The O/W cream was found to be stable for 3 months without degradation 28 .…”

Section: Continuous Manufacturingmentioning

confidence: 95%

Novel Applications of Hot Melt Extrusion Technology

Samanthula

Kemisetti

Mandhadi

et al. 2023

“…The prepared creams were tested for viscosity, in-vitro drug release and permeation. The results indicated that voriconazole oil in PEG cream was successfully prepared through twin screw processor and Transcutol P was successful in enhancing permeation of voriconazole 37 .…”

Section: Semi-solidsmentioning

confidence: 96%

Application of Lipids in Hot Melt Extrusion Technology

Dindigala,

Kodam

2023

Lipids are commonly used excipients in drug delivery for improving solubility of low soluble drugs, enhancing bioavailability through avoiding first pass metabolism through nanoparticulate approach, modifying the drug release, binders, permeation enhancers, transfection agents etc. Lipids alone or in combination of polymers are increasingly being used in hot melt extrusion (HME) technology for preparation of controlled release formulations, solid dispersions, self-emulsifying drug delivery systems, semi-solid formulations, solid lipid nanoparticles and others. Properties like low melting temperature, viscosity, ability to extrude at low temperature and ability to load high doses of drug favor use of lipids in HME technology. This review emphasizes the use of lipids for variety of applications in HME technology. Keywords: Lipids, Hot melt extrusion, solubility, bioavailability, parameters.

“…Transdermal drug delivery like buccal drug delivery can be particularly useful for drugs that undergo systemic metabolism and can also deliver the drug in a controlled fashion [28][29][30] . Mohd et al, prepared transdermal patches of pinacidil monohydrate for drug delivery through a percutaneous route.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Approaches to Improve Oral Bioavailability of Antihypertensive Drugs: A Mini-Review

Dole,

Kothapally,

Chukkala

et al. 2023

Hypertension elevates the risk of heart disease and stroke which are one of the most frequent causes of death. Fortunately, hypertension is manageable with the use of anti-hypertensives and a healthy lifestyle. However, patient non-adherence to the prescribed dosing regimen is the primary reason for uncontrolled blood pressure levels. Daily multiple doses of medication are one of the major reasons for patient non-compliance to the dosing regimen. Multiple doses of medication are a result of low solubility and high first-pass metabolism of anti-hypertensives. There are several approaches to improve the bioavailability of anti-hypertensives like polymeric and non-polymeric approaches to enhance solubility, avoiding first-pass metabolism through alternate routes of drug delivery and others. The objective of this review is to discuss different approaches to enhance the oral bioavailability of anti-hypertensive drugs. Keywords: Solubility enhancements, solid lipid nanoparticles, hot melt extrusion, drug delivery, pharmacokinetics, poorly soluble, oral bioavailability.