Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate

Kawano, Yoshiro; Imamura, Ayano; Nakamura, Tomoe Y.; Akaishi, Mio; Satoh, Mitsutoshi; Hanawa, Takehisa

doi:10.1248/cpb.c16-00217

Cited by 10 publications

(13 citation statements)

References 24 publications

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“…Irsogladine maleate (IM) has gastric mucosal protective properties. IM increases intracellular cAMP levels in the gastric mucosa and activates communication between cells [52]. IM inhibits production of reactive oxygen species and act as ROS scavenger [35].…”

Section: Systemic Irsogladine Maleatementioning

confidence: 99%

Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines

Ariyawardana

Cheng²,

Kandwal

et al. 2019

Support Care Cancer

101

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The aim of this systematic review was to update the clinical practice guidelines for the use of anti-inflammatory agents in the prevention and/or treatment of oral mucositis. Methods A systematic review was conducted by the Multinational Association of Supportive Care in Cancer/ International Society of Oral Oncology (MASCC/ISOO) subcommittee on mucositis guideline update. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the clinical practice guidelines published in 2014. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guidelines. Results A total of 11 new papers across five interventions were examined. The recommendation for the use of benzydamine mouthwash for the prevention of radiotherapy-induced mucositis remained unchanged. New suggestion for the use of the same for prevention of mucositis associated with chemoradiotherapy was made. No guideline was possible for any other antiinflammatory agents due to inadequate and/or conflicting evidence. Conclusions Of the anti-inflammatory agents studied for oral mucositis, the evidence supports the use of benzydamine mouthwash in the specific populations listed above. Additional well-designed research is needed on other (class of agents) interventions and in other cancer treatment settings.

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Section: Systemic Irsogladine Maleatementioning

confidence: 99%

Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines

Ariyawardana

Cheng²,

Kandwal

et al. 2019

Support Care Cancer

101

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“…Hydroxypropyl-β-CD eliminates the unpleasant taste of irsogladine maleate used for treatment of stomatitis. Addition of the macrocycle to the mucoadhesive gum ghatti, consisting of high-molecular-weight polysaccharides, leads to the formation of a viscous solution as a result of aggregation due to hydrogen bonds between the macrocycle and the polymer [ 257 ].…”

Section: Mucoadhesive Properties Of Supramolecular Systems Based Omentioning

confidence: 99%

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Kashapov

Gaynanova

Gabdrakhmanov

et al. 2020

IJMS

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This review focuses on synthetic and natural amphiphilic systems prepared from straight-chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale aggregates of different morphology and their application as drug carriers. Since numerous biological species (lipid membrane, bacterial cell wall, mucous membrane, corneal epithelium, biopolymers, e.g., proteins, nucleic acids) bear negatively charged fragments, much attention is paid to cationic carriers providing high affinity for encapsulated drugs to targeted cells. First part of the review is devoted to self-assembling and functional properties of surfactant systems, with special attention focusing on cationic amphiphiles, including those bearing natural or cleavable fragments. Further, lipid formulations, especially liposomes, are discussed in terms of their fabrication and application for intracellular drug delivery. This section highlights several features of these carriers, including noncovalent modification of lipid formulations by cationic surfactants, pH-responsive properties, endosomal escape, etc. Third part of the review deals with nanocarriers based on macrocyclic compounds, with such important characteristics as mucoadhesive properties emphasized. In this section, different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.

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“…Several studies on new oral mucosa formulations are also in progress. [1][2][3] Semisolid type, patch type, and spray type formulations can be considered as a typical preparation for the oral mucosa, although the spray type has not been studied extensively. 4) Aphthous stomatitis is one of the target diseases for such a preparation.…”

Section: Introductionmentioning

confidence: 99%

Development of Spray Formulations Applied to the Oral Mucosa Using Non-lamellar Liquid Crystal-Forming Lipids

Sugibayashi

Yamamoto

Itakura

et al. 2020

CHEMICAL & PHARMACEUTICAL BULLETIN

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We examined the physicochemical and biochemical properties of mono-O-(5,9,13-trimethyl-4tetradecenyl)glycerol ester (MGE), including ease of handling, high bioadhesiveness, quick and stable in vivo self-organization (forming a non-lamellar lyotropic liquid crystal [NLLC]), and high biomembrane permeation enhancement. We prepared MGE oral mucosa-applied spray preparations containing triamcinolone acetonide (TA), which is widely used in the treatment of stomatitis, and we examined the usefulness of the MGE preparations compared with commercially available oral mucosal application preparations containing 2,3-dihydroxypropyl oleate (1-mono(cis-9-octadecenoyl)glycerol (GMO) (previously studied as an NLLCforming lipid) preparation. As a result, the MGE preparation applied to the oral mucosa can rapidly formed an NLLC with reverse hexagonal or cubic structures, or a mixture, on contact with water. In addition, by adding hydroxypropyl cellulose to the MGE preparation, similar retention properties on the oral mucous membrane were obtained to that using marketed drug preparations. Furthermore, the MGE spray formulation on the oral mucosa showed an equivalent or higher TA release as well as oral mucous membrane permeability compared with commercial formulations. Because MGE forms a stable NLLC and is easy to handle compared with GMO, MGE was considered to be a useful pharmaceutical additive for a spray preparation applied to the oral mucosa in combination.

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Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate

Cited by 10 publications

References 24 publications

Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines

Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Development of Spray Formulations Applied to the Oral Mucosa Using Non-lamellar Liquid Crystal-Forming Lipids

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