Development and Characterization of Orodispersible Tablets of Propranolol Hydrochloride Using Calcium Cross-Linked Cassia Fistula Gum and Cross Carmellose Sodium

Abstract

<jats:p>Objective: The present investigation was aimed towards developing calcium crosslinked derivative of carboxymethylated cassia fistula gum and crosscarmellose sodium based orodispersible tablets (ODTs) of propranolol hydrochloride for enhancing the bioavailability and efficacy.&#x0D; Methods: Orodispersible tablets (ODTs) of propranolol hydrochloride was formulated using natural (a carboxymethylated derivative of cassia fistula gum) and synthetic polymer (crosscarmellose sodium) by wet and dry granulation, lyophilization and cotton candy methods and then finally compressed by direct compression. The prepared ODTs were evaluated for several parameters such as hardness, friability, in vitro disintegration time, in vitro drug release. In vivo and stability studies were carried out on optimized formulation coding PC1.&#x0D; Results: Drug polymer interaction were judged by FT-IR, DSC and XRD. The optimized formulation coding PC1 prepared by cotton candy process containing 2.5% w/w of crosslinked cassia fistula gum has the least disintegration time (18.9±0.4s), weeting time (12.5±0.8s) and relased the drug of 88.2% within 10 min in contrast to croscarmellose sodium. In vivo absorption studies revealed that same formulation has Cmax (µg/ml) 2.13±0.73, tmax (h) 0.21±0.17 and (µg ml-1 h-1) 14.33±1.59.&#x0D; Conclusion: This research manuscript clearly shows the successful development of the ODTs loaded with an antihypertensive drug, namely propranolol hydrochloride. The formulation developed by cotton candy process utilizing crosslinked cassia fistula gum as a natural superdisintegrant in contrast to other existing techniques can be a best option over synthetic superdisintegrant i.e. crosscarmellose sodium. The prepared ODTs was enhanced the absorption rate by lowering tmax, which inturn enhance the bioavailability and the efficacy of drug.</jats:p>

Development and Characterization of Oro-Dispersible Tablets of Metformin Hydrochloride Using Cajanus Cajan Starch as a Natural Superdisintegrant

“…To determine the release model that best describes the drug release mechanism, in vitro release data of Metformin hydrochloride orodispersible tablets was fitted into zero -order, first-order, Higuchi, Korsmeyer Peppas, and Hixon Crowell release models. The release pattern of a specific mechanism was based on the correlation coefficient (R²) for the parameters studied [33,34]. The highest correlation coefficient is preferred for selecting the mechanism of release.…”

Design, development and in vivo pharmacokinetic of telmisartan loaded oral disintegration tablets

“…Dry it in a tray dryer at 60ºC for 10 min and to the dried granules, add a remaining quantity of super disintegrants, glidants, lubricants. Punch it in a 16/32 punch to get ODT (Hoffmann et al, 2020;Singh and Verma, 2020;Singh and Sharma, 2020).…”