Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH

Hallan, Supandeep Singh; Kaur,; Jain,; Mishra, Neeraj

doi:10.1080/21691401.2016.1276920

Cited by 22 publications

(9 citation statements)

References 31 publications

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“… 4 Compared to heparin, LMWH has the advantages of high bioavailability, a strong antithrombotic effect, and fewer bleeding side effects. 5 , 6 Therefore, LMWH is increasingly widely used in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cold Application on Pain and Bruising in Patients With Subcutaneous Injection of Low-Molecular-Weight Heparin: A Meta-Analysis

Wang

Zhang

Wang

et al. 2020

Clin Appl Thromb Hemost

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To evaluate the effect of cold application on pain and bruising after the subcutaneous injection of low-molecular-weight heparin, 8 electronic databases were searched for randomized controlled trials and quasiexperimental studies from the inception of the databases to June 2019. Review Manager 5.3 software was used for the heterogeneity test and meta-analysis. A total of 8 studies including 694 participants were analyzed. The cold application group assessed with the Verbal Descriptor Scale pain assessment tool showed significant reductions in pain intensity immediately after injection. Compared to the control group, the cold application group showed a reduction in the occurrence of bruises at 12 hours, 24 hours, and 48 hours after injection. There was no significant difference in the area of bruising in the cold application group at 48 hours after injection, but the area of bruising at 72 hours after injection was significantly reduced. These results show that cold application can reduce the incidence of pain and bruising after subcutaneous injection of low-molecular-weight heparin and reduce the area of bruising 72 hours after injection. Additional studies with larger sample sizes are needed to confirm these findings.

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Section: Introductionmentioning

confidence: 99%

Effect of Cold Application on Pain and Bruising in Patients With Subcutaneous Injection of Low-Molecular-Weight Heparin: A Meta-Analysis

Wang

Zhang

Wang

et al. 2020

Clin Appl Thromb Hemost

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“…A variety of techniques are available for the preparation of PLNs, such as solvent diffusion,26 high pressure homogenization,27 and emulsification-evaporation 28. Solvent diffusion method is also referred as nanoprecipitation technique, in which the miscible solvent rapidly diffuses into the aqueous phase, resulting in coprecipitation of polymer and lipid materials due to decline of solubility and formation of nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

<p>Cholate-modified polymer-lipid hybrid nanoparticles for oral delivery of quercetin to potentiate the antileukemic effect</p>

Yin

Hou

Song

et al. 2019

IJN

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Background: Quercetin (QUE) shows a potential antileukemic activity, but possesses poor solubility and low bioavailability. Purpose: This article explored the bile salt transport pathway for oral deliver of QUE using cholate-modified polymer-lipid hybrid nanoparticles (cPLNs) aiming to enhance its antileukemic effect. Methods: QUE-loaded cPLNs (QUE-cPLNs) were developed through a nanoprecipitation technique and characterized by particle size, entrapment efficiency (EE), microscopic morphology and in vitro drug release. In vitro cellular uptake and cytotoxicity of QUE-cPLNs were examined on Caco-2 and P388 cells; in vivo pharmacokinetics and antileukemic effect were evaluated using Sprague Dawley rats and leukemic model mice, respectively. Results: The prepared QUE-cPLNs possessed a particle size of 110 nm around with an EE of 96.22%. QUE-cPLNs resulted in significantly enhanced bioavailability of QUE, up to 375.12% relative to the formulation of suspensions. In addition, QUE-cPLNs exhibited excellent cellular uptake and internalization capability compared to cholate-free QUE-PLNs. The in vitro cytotoxic and in vivo antileukemic effects of QUE-cPLNs were also signally superior to free QUE and QUE-PLNs. Conclusion: These findings indicate that cPLNs are a promising nanocarrier able to improve the oral bioavailability and therapeutic index of QUE.

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“…The use of cationic polymer increases the loading efficiency of drug (heparin) in the lipid carrier, and chitosan is recognized to improve the passage of heparin across the intestinal membrane through tight junctions. Chitosan when used as a constituent of the hybrid system increases the entrapment efficiency of lipid nanoparticle [26] .…”

Section: Types Of Hybrid Nanocarriersmentioning

confidence: 99%

Inhalable hybrid nanocarriers for respiratory disorders

Maurya

Singh

Saraf

2020

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

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Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH

Cited by 22 publications

References 31 publications

Effect of Cold Application on Pain and Bruising in Patients With Subcutaneous Injection of Low-Molecular-Weight Heparin: A Meta-Analysis

Effect of Cold Application on Pain and Bruising in Patients With Subcutaneous Injection of Low-Molecular-Weight Heparin: A Meta-Analysis

<p>Cholate-modified polymer-lipid hybrid nanoparticles for oral delivery of quercetin to potentiate the antileukemic effect</p>

Inhalable hybrid nanocarriers for respiratory disorders

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