Development and Characterization of Propranolol Selective Molecular Imprinted Polymer Composite Electrospun Nanofiber Membrane

Abstract

Abstract. Propranolol (PPL) imprinted microspheres (MIP) were successfully prepared via oil/water polymerization using a methyl methacrylate (MMA) monomer, PLL template, and divinylbenzene (DVB) cross-linker and favorably incorporated in a Eudragit-RS100 nanofiber membrane. A non-PPL imprinted polymer (NIP), without a template, was used as a control. The morphology and particle size of the beads were investigated using scanning electron microscopy. The results revealed that both MIP and NIP had a spherical shape with a micron size of approximately 50-100 μm depending on the amounts of DVB and PPL used. NIP2 (MMA/DVB, 75:2.5) and MIP8 (PPL/MMA/DVB, 0.8:75:2.5) were selected for reloading of PPL, and the result indicated that increasing the ratio of PPL to polymer beads resulted in increase PPL reloading (>80%). A total of 10-50% NIP2 or MIP8 was incorporated into a 40%(w/v) Eudragit-RS100 fiber membrane using an electrospinning technique. PPL could be bound to the 50% MIP8 composite fiber membrane with a higher extent and at a higher rate than the control (NIP2). Furthermore, the MIP8 composite fiber membrane showed higher selectivity to PPL than the other β-blockers (atenolol, metoprolol, and timolol). Thus, the MIP8 composite fiber membrane can be further developed for various applications in pharmaceutical and other affinity separation fields.

Recent developments in molecularly imprinted polymer nanofibers and their applications

“…Firstly, cinchonidine MIP microspheres of 4-5 µm were synthesized with Yoshikawa and co-workers prepared and demonstrated the comparison results for the fabrication of molecularly imprinted membranes (MIPMs) and molecularly imprinted nanofiber membranes (MINFMs) from polysulfone with aldehyde and N-α-benzyloxycarbonyl-d-glutamic acid (Z-d-Glu) N-α-benzyloxycarbonyl-l-glutamic acid (Z-l-Glu) as a print molecule using molecular imprinting and an electrospray deposition techniques, respectively. 30 Li et al 31 HPLC. However, the MINFMs offered one to two orders of magnitude higher flux than those of usual MIPMs without depression of permselectivity.…”

Ionic liquids as porogens for molecularly imprinted polymers: propranolol, a model study

“…Thus the combination of MAA and DVB was deemed to be the most suitable for the development of subsequent MIPs. This combination of a cross linker and a functional monomer has been used previously in the development of selective MIPs [31][32][33][34][35]. MIPs were subsequently synthesised using[BMIM][BF 4 ] (MIP BF4 ), [BMIM][PF 6 ] (MIP PF6 ) and CHCl 3 (MIP CHCl3 ) as the porogens.…”

ForceSpinning of polyacrylonitrile for mass production of lithium‐ion battery separators

“…The separator, whose main function is to keep the positive and negative electrodes apart in order to prevent electrical short circuits while allowing rapid transport of ionic charge carriers across the interface, has received considerable research attention recently. [7][8][9][10][11] These nanofibers can be produced by several methods such as electrospinning, 12,13 electrospray, wet laid, melt blowing, and microwave-assisted processes. [1][2][3][4][5] A majority of the separators currently used in LIBs are those typically developed as spinoffs of existing technologies and not designed specifically for a particular battery chemistry.…”

“…Polymeric nanofiber membranes in recent times have seen extensive research activities for their use as alternate separators in Li-ion batteries due to their large porosity, unique pore structure, and high electrolyte uptake. [7][8][9][10][11] These nanofibers can be produced by several methods such as electrospinning, 12,13 electrospray, wet laid, melt blowing, and microwave-assisted processes. However, these methods have some drawbacks, such as low spinning rate and high production cost.…”