Development and characterization of solid lipid nanoparticles for enhancement of oral bioavailability of Raloxifene

Patel, Brijesh; Modi, Rutu; Thakkar, Nilay; Patel, Akanksha; Thakkar, Parth

doi:10.4103/0975-7406.94121

Cited by 17 publications

(4 citation statements)

References 1 publication

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“…The utilization of nano minerals in livestock has been found to enhance the bioavailability of minerals, leading to improvements in animal growth, production, and health [26]. Numerous research studies have indicated that the bioavailability of materials is considerably enhanced when they are prepared in nanometer size [43]. It is postulated that the bioavailability of iron can be enhanced through the reduction of iron-containing compounds to nanometer size, akin to the effects observed with zinc phosphatebased nanoparticles and zinc supplements [44].…”

Section: Effect Of Nano Iron Supple-mentation On the Performance Of P...mentioning

confidence: 99%

A Comprehensive Review of the Efficacy, Mechanisms and Future Prospects of Nano Iron Supplementation in Piglets

Nirmala,

Balusamy,

Stephan

et al. 2023

CJAST

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Nanotechnology is a promising avenue for innovative research and development, with recent applications such as the production of nutrients with enhanced bioavailability. The distinctive characteristics of nano metals such as their larger specific surface area, heightened surface activity, greater catalytic efficiency and stronger adsorption capabilities result in an enhanced bioavailability. Small particles are easily transported through the gastrointestinal tract and can be assimilated by the animal resulting in higher efficacy compared to larger particles. Nanoparticles have the potential to serve as a vehicle for the delivery of medication, nutrients, probiotics, supplements, and other substances to the feed of livestock and poultry. Iron (Fe) is an essential micronutrient that is indispensable for swine due to its critical function in regulating blood hemostasis and hemoglobin levels. Iron deficiency anemia (IDA) is a prevalent condition solely observed in swine. The susceptibility of iron deficiency in piglets is positively correlated with their size, owing to their increased blood volume and hemoglobin utilization capacity. Iron nanoparticles, also known as IONPs, have become a powerful tool in a variety of biomedical and environmental contexts. The enhanced surface area, surface activity and catalytic efficiency of nano minerals make them a promising option for animal mineral feed supplements, even at lower dosages relative to traditional sources. The objective of this review is to elucidate the effectiveness of nano iron fortification in piglets as a prophylactic measure against anemia.

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Section: Effect Of Nano Iron Supple-mentation On the Performance Of P...mentioning

confidence: 99%

A Comprehensive Review of the Efficacy, Mechanisms and Future Prospects of Nano Iron Supplementation in Piglets

Nirmala,

Balusamy,

Stephan

et al. 2023

CJAST

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show abstract

“… Figure 2 shows the new ones, specifically those developed for oral administration of active compounds (in italic). In addition, polymer-based delivery systems (PBDS) have also been popularly adopted to increase the clinical efficacy of some Phy, as observed in Table 4 [63, 64]. To a lesser extent, inclusion complexes with cyclodextrins and its derivatives as well as inorganic, hybrid, and other novel nanocarriers are being currently used (Table 4).…”

Section: Use Of Lipid-based Delivery Systems To Increase the Clinimentioning

confidence: 99%

ImprovingIn VivoEfficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems

Mouhid

Corzo‐Martínez

Torres

et al. 2017

Journal of Oncology

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Cancer is among the leading causes of morbidity and mortality worldwide. Many of the chemotherapeutic agents used in cancer treatment exhibit cell toxicity and display teratogenic effect on nontumor cells. Therefore, the search for alternative compounds which are effective against tumor cells but reduce toxicity against nontumor ones is of great importance in the progress or development of cancer treatments. In this sense, scientific knowledge about relevant aspects of nutrition intimately involved in the development and progression of cancer progresses rapidly. Phytochemicals, considered as bioactive ingredients present in plant products, have shown promising effects as potential therapeutic/preventive agents on cancer in several in vitro and in vivo assays. However, despite their bioactive properties, phytochemicals are still not commonly used in clinical practice due to several reasons, mainly attributed to their poor bioavailability. In this sense, new formulation strategies are proposed as carriers to improve their bioefficacy, highlighting the use of lipid-based delivery systems. Here, we review the potential antitumoral activity of the bioactive compounds derived from plants and the current studies carried out in animal and human models. Furthermore, their association with lipids as a formulation strategy to enhance their efficacy in vivo is also reported. The development of high effective bioactive supplements for cancer treatment based on the improvement of their bioavailability goes through this association.

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“…2% of the given dose) which is mostly due to its extensive first pass hepatic metabolism via glucuronide conjugation as well as incomplete dissolution as the drug is poorly water-soluble. 2 , 3 This drug is categorized as class II of Biopharmaceutical Classification System (BCS). 4 Accordingly, its low bioavailability seems to be enhanced by increasing its solubility.…”

Section: Introductionmentioning

confidence: 99%

Porous Microparticles Containing Raloxifene Hydrochloride Tailored by Spray Freeze Drying for Solubility Enhancement

2018

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Purpose: The goal of this study was to improve the solubility and dissolution behavior of Raloxifene Hydrochloride (RH) using Spray Freeze Drying (SFD) technique.Methods: For achieving this goal, series of samples containing RH with polyvinylpyrrolidone (PVP) or hydroxypropyl beta cyclodextrin (HPβCD) used as solubility enhancers were prepared and microparticles were formed via SFD. The resultant microparticles were physicochemically characterized. Morphology of the microparticles were observed using Scanning Electron Microscopy (SEM). High Performance Liquid Chromatography (HPLC) was used for analyzing the solubility and dissolution profile of the samples.Results: Fourier Transmission Infrared (FTIR) spectra showed that SFD processed compositions did not affect chemical structure of RH. SEM and Thermal Gravimetric Analysis (TGA) revealed that the fabricated spherical and highly porous microparticles were in amorphous state. SFD processed powders showed superior solubility and dissolution behavior; where, 80% of the drug was dissolved within 5 minutes.Conclusion: SFD method can be a promising alternative for enhancing the solubility of poorly water soluble compounds.

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Development and characterization of solid lipid nanoparticles for enhancement of oral bioavailability of Raloxifene

Cited by 17 publications

References 1 publication

A Comprehensive Review of the Efficacy, Mechanisms and Future Prospects of Nano Iron Supplementation in Piglets

A Comprehensive Review of the Efficacy, Mechanisms and Future Prospects of Nano Iron Supplementation in Piglets

ImprovingIn VivoEfficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems

Porous Microparticles Containing Raloxifene Hydrochloride Tailored by Spray Freeze Drying for Solubility Enhancement

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