Development and Characterization of Solid-Lipid Microparticles of Highly Insoluble Drug Sirolimus

Nanjwade, Basavaraj K.; Patel, Didhija J.; Parikh, Kemy A.; Nanjwade, Veerendra K.; Manvi, F. V.

doi:10.4172/jbb.1000050

Cited by 17 publications

(17 citation statements)

References 14 publications

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“…SLH microparticle formulations of F1-F5 and F11-F15 were prepared by taking known amount of drug (20 mg), lipid (Phospolipoid 90H) (5 mg), different oil:surfactant (soya bean oil/ miglyol 812:Tween 80) ratio of 2:1,4:1,6:1,8:1 and 10:1, respectively. Formulations F6-F10 and F16-F20 were prepared by keeping the oil:surfactant ratio constant at 10:1, and by increasing the lipid concentration from 5 to 10 mg. [11][12][13] Compositions of various formulations are given in the (Table 1 and 2). …”

Section: Formulation Of Silica Lipid Hybrid (Slh) Microparticles Of Fmentioning

confidence: 99%

Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro and ex vivo Evaluation

Sambaraj¹,

Ammula²,

Nagabandi³

2015

Adv Pharm Bull

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Section: Formulation Of Silica Lipid Hybrid (Slh) Microparticles Of Fmentioning

confidence: 99%

Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro and ex vivo Evaluation

Sambaraj¹,

Ammula²,

Nagabandi³

2015

Adv Pharm Bull

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“…The prepared sample should be an aliquot relatively free of interferences that is compatible with the HPLC method and that will not damage the column [28]. The main sample preparation techniques are liquid-liquid extraction (LLE) [29,30] and solid-phase extraction (SPE) [31].…”

Section: Sample Preparationmentioning

confidence: 99%

Development and Validation of Analytical Methods for Pharmaceuticals

Toomula¹

2011

J Anal Bioanal Tech

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Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. The official test methods that result from these processes are used by quality control laboratories to ensure the identity, purity, potency, and performance of drug products. This review gives information regarding various stages involved in development and validation of analytical methods like LC, HPLC, MS.

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“…At the time of identification of drug's biological properties, metabolic feature of the drug and understanding of pharmacokinetic the bioanalytical methods playing key role. The bioanalytical method used to determine the drug and its metabolites in serum, plasma, urine [6][7][8][9][10][11][12] . 3 OH in the ratio of 50:35:15v/v at pH 6.0 linear in the ranges are 400-600µg/ml for Lopinavir and 100-150 µg/ml for RTNVR.…”

Section: Introductionmentioning

confidence: 99%

New Analytical HPLC Method Development and Validation for the Simultaneous Quantification of Paritaprevir Ombitasvir and Ritonavirin Spiked Human Plasma.

R.S.Ch¹,

Prasad²,

Mallu³

2017

Orient. J. Chem

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A rapid HPLC bio-analytical method has been developed and validated for the simultaneous quantification of Ombitasvir (OMBTSR), Ritonavir (RTNVR), Paritaprevir (PTVR) in human plasma. OMBTSR and PTVR are used to control Hepatitis-C infection. RTNVR is used in the treatment of HIV/AIDS. The method was developed with Column (Intersil ODSC 18, 250 mm × 4.6 mm × 5µ) at 230 nm wave length and at flow rate of 1.0 mL/min. The mobile phase consisted of 20% Acetonitrile, 20% Methanol, 60% 1mM NH 4 H 2 PO 4 Buffer(P H 6.5 v/v). The retention times of RTNVR, OMBTSR, PTVR are 5.7 min. 7.8 min. and 12.8 min. respectively. The method was developed and validated in terms of linearity, interday precision, intraday precision, accuracy, LOQ, LOD and stability study. The proposed method is useful in pharmacokinetic studies using HPLC or LC-MS.

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Development and Characterization of Solid-Lipid Microparticles of Highly Insoluble Drug Sirolimus

Cited by 17 publications

References 14 publications

Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro and ex vivo Evaluation

Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro and ex vivo Evaluation

Development and Validation of Analytical Methods for Pharmaceuticals

New Analytical HPLC Method Development and Validation for the Simultaneous Quantification of Paritaprevir Ombitasvir and Ritonavirin Spiked Human Plasma.

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