Development and characterization of thermopressed polyvinyl alcohol films for buccal delivery of benznidazole

Amaral, Beatriz Ribeiro; Saatkamp, Rodrigo H.; Enumo, Adalberto; Kroth, Roselene; Argenta, Débora Fretes; Rebelatto, Elisa Regina Lazzarotto; Rauber, Gabriela Schneider; Parize, Alexandre Luís; Caon, Thiago

doi:10.1016/j.msec.2020.111546

Cited by 8 publications

(2 citation statements)

References 38 publications

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“…BNZ toxicity results from the required administration of high oral doses of drug that are required to achieve a therapeutic plasma dose; this is largely due to the drug's high hydrophobicity. Improvements in BNZ formulation have been achieved (Davanco et al, 2016;Bezerra et al, 2020;Amaral et al, 2021;Ndayishimiye et al, 2021) and micro-and nano-carriers have emerged as a strategy to decrease BNZ toxicity by overcoming poor aqueous solubility, increasing BNZ bioavailability and increasing concentration inside T. cruzi infected cells (Quezada et al, 2019;Seremeta et al, 2019;Pandian et al, 2021).…”

Section: American Trypanosomiasis: Chagas Diseasementioning

confidence: 99%

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Scariot

Staneviciute

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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Nanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve the pharmacokinetic properties of bioactive molecules. The development of advanced nanomaterials has greatly enhanced drug discovery through improved pharmacotherapeutic effects and reduction of toxicity and side effects. Therefore, highly toxic treatments such as cancer chemotherapy, have benefited from nanotechnology. Considering the toxicity of the few therapeutic options to treat neglected tropical diseases, such as leishmaniasis and Chagas disease, nanotechnology has also been explored as a potential innovation to treat these diseases. However, despite the significant research progress over the years, the benefits of nanotechnology for both diseases are still limited to preliminary animal studies, raising the question about the clinical utility of nanomedicines in this field. From this perspective, this review aims to discuss recent nanotechnological developments, the advantages of nanoformulations over current leishmanicidal and trypanocidal drugs, limitations of nano-based drugs, and research gaps that still must be filled to make these novel drug delivery systems a reality for leishmaniasis and Chagas disease treatment.

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Section: American Trypanosomiasis: Chagas Diseasementioning

confidence: 99%

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Scariot

Staneviciute

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Recently, polymeric film matrices have demonstrated their potential as efficient drug dosage platforms due to their ability to: (a) enhance drug efficacy and the onset of drug action, (b) reduce dosage frequency, (c) improve drug retention, and (d) increase patient compliance [29,30]. Since PVA exhibits excellent film-forming capacity [31], many researchers have employed this property to develop PVA-based films for ophthalmic [32], oral [33], buccal [34], topical [5], transdermal [35], and vaginal [36] drug delivery applications. Furthermore, PVA has also been known to synthesize blends with natural polysaccharides (e.g., chitosan, alginate, starch, and tara gum) to prepare films with improved mechanical and thermal properties [37,38].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films

Qureshi

Sahoo

Mohanty³

et al. 2021

Gels

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In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5–10.0 wt% within the films. The inclusion of COS added a brown hue to the films. FTIR spectroscopy revealed that the extent of intermolecular hydrogen bonding was most prominent in the film that contained 5.0 wt% of COS. The diffractograms showed that COS altered the degree of crystallinity of the films in a composition-dependent manner. As evident from the thermal analysis, COS content profoundly impacted the evaporation of water molecules from the composite films. Stress relaxation studies demonstrated that the blend films exhibited more mechanical stability as compared to the control film. The impedance profiles indicated the capacitive-dominant behavior of the prepared films. Ciprofloxacin HCl-loaded films showed excellent antimicrobial activity against Escherichia coli and Bacillus cereus. The prepared films were observed to be biocompatible. Hence, the prepared PVA/COS-based blend films may be explored for drug delivery applications.

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Oral Patch/Film for Drug Delivery—Current Status and Future Prospects

Yan,

et al. 2024

Biopolymers

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In recent years, there has been extensive research into drug delivery systems aimed at enhancing drug utilization while minimizing drug toxicities. Among these systems, oral patches/films have garnered significant attention due to their convenience, noninvasive administration, ability to bypass hepatic first‐pass metabolism, thereby enhancing drug bioavailability, and their potential to ensure good compliance, particularly among special patient populations. In this review, from the perspective of the anatomical characteristics of the oral cavity and the advantages and difficulties of oral drug delivery, we illustrate the design ideas, manufacturing techniques, research methodologies, and the essential attributes of an ideal oral patch/film. Furthermore, the applications of oral patches/films in both localized and systemic drug delivery were discussed. Finally, we offer insights into the future prospects of the oral patch/film, aiming to provide valuable reference for the advancement of oral localized drug delivery systems.

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Development and characterization of thermopressed polyvinyl alcohol films for buccal delivery of benznidazole

Cited by 8 publications

References 38 publications

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films

Oral Patch/Film for Drug Delivery—Current Status and Future Prospects

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