Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications

Abstract

Implants are used to replace damaged biological structures in human body. Although stainless steel (SS) is a well-known implant material, corrosion of SS implants leads to the release of toxic metallic ions, which produce harmful effects in human body. To prevent material degradation and its harmful repercussions, these implanted materials are subjected to biocompatible coatings. Polymeric coatings play a vital role in enhancing the mechanical and biological integrity of the implanted devices. Zein is a natural protein extracted from corn and is known to have good biocompatibility and biodegradability. In this study, zein/Ag-Sr doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were deposited on SS substrates via electrophoretic deposition (EPD) at different parameters. Ag and Sr ions were added to impart antibacterial and osteogenic properties to the coatings, respectively. In order to examine the surface morphology of coatings, optical microscopy and scanning electron microscopy (SEM) were performed. To analyze mechanical strength, a pencil scratch test, bend test, and corrosion and wear tests were conducted on zein/Ag-Sr doped MBGN coatings. The results show good adhesion strength, wettability, corrosion, and wear resistance for zein/Ag-Sr doped MBGN coatings as compared to bare SS substrate. Thus, good mechanical and biological properties were observed for zein/Ag-Sr doped MBGN coatings. Results suggested these zein/Ag-Sr MBGNs coatings have great potential in bone regeneration applications.

Electrophoretic Deposition, Microstructure, and Selected Properties of Poly(lactic-co-glycolic) Acid-Based Antibacterial Coatings on Mg Substrate

“…The composite coating displayed minimal delamination (<5%). According to ASTM D3359 standards, the adhesion strength was rated as “4B”, proving that the coating has suitable adhesion strength for orthopedic applications. , …”

“…According to ASTM D3359 standards, the adhesion strength was rated as "4B", proving that the coating has suitable adhesion strength for orthopedic applications. 2,56 3.6.2. Bend Test.…”

Studying and Characterization of Coating of Zein–CaSiO3 Composite on Polyetheretherketone Implant Material

“…A cross cut area significantly greater than 35%, but not significantly greater than 65%, is affected Any degree of flaking that cannot be classified even by classification 4 (1B) mechanical strength of the coatings. Batool et al [42] demonstrated that a polymer matrix (e.g., zein) can act as a binder to hold another material on the surface and thus increase the mechanical stability of coatings. This study was limited to studying the mechanical properties of different concentrations of zein with a calcium silicate composite coating on PEEK implant material.…”

Influence of Mesoporous Bioactive Glass Particles Doped with Cu and Mg on the Microstructure and Properties of Zein-Based Coatings Obtained by Electrophoretic Deposition

“…The addition of ceramics to zein also increases the mechanical strength of the coatings. The available literature includes information on the use of hydroxbioactive mesoporous glass, 27 hydroxyapatite, 28 silica, 29 or dense bioactive glass particles 24,30 as bioactive components in zein coatings. In biomedical engineering, interest in silica-based bioactive glass is growing due to its bioactivity, osteoinductivity and antibacterial effects.…”

“…45,46 Among the available literature, there are not many publications reporting the EPD of zein coatings incorporating mesoporous sol-gel bioactive glasses. Batool et al 27 reported a successful attempt at EPD of zein-based coatings containing mesoporous bioactive glass nanoparticles doped with Ag-Sr (Ag-Sr MBGNs) on 316 L stainless steel substrates. The suspension used consisted of zein (6 wt%), distilled water (20 wt%), ethanol (74 wt%), acetic acid (∼10 ml to reduce the pH to ∼3) and Ag-Sr MBGNs (3*10 −3 kg dm −3 ) added to a 100 ml beaker.…”