Development and clinical assessment of an artificial cornea

AlphaCor artificial cornea: clinical outcome

“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Several complications, associations, and risk factors have been identified. [21][22][23][24][25] The indications and surgical techniques have been evolving with experience.…”

Modified Osteo Odonto Keratoprosthesis (MOOKP) - "Tooth For An Eye"

“…The mucosal flap is replaced after cutting a hole to allow the protrusion of the anterior part of the optical cylinder Stage II surgery is performed 2 to 3 months later to allow time for a connective tissue cover to develop around the lamina implanted in the cheek. If required, the integrity of the lamina can be checked by performing a spiral computed tomographic evaluation [25]. During the second stage surgery, the lamina is retrieved from the subcutaneous location and excess connective tissue is removed from the two ends of the optic cylinder, and carefully trimmed over the rest of the lamina.…”

Poly (ε-caprolactone) nanofibrous ring surrounding a polyvinyl alcohol hydrogel for the development of a biocompatible two-part artificial cornea

“…[1][2][3][4][5] Corneal blindness is a major and widespread eye problem, with approximately 10 million people worldwide who are blind because of corneal disorders. 2,3,[6][7][8][9][10] Injury to the cornea can be a consequence of trauma, burns, infections, disease scars, and previous surgery resulting in inflammation, vascularization, scar formation, opacification, and finally blindness. 1,6,11 The current treatment of corneal blindness is penetrating keratoplasty or corneal transplantation.…”

“…Therefore, the development of an "artificial cornea" (keratoprosthesis, KPro) is a desirable option to overcome these problems. 2,3,5,[8][9][10][11][12] An artificial cornea generally consists of an optical central part or "core" that should be transparent, and a biocompatible peripheral part or "skirt" that should allow for cellular integration. 13 The main problem of KPro was, and still is, the rejection of the prosthesis or "extrusion" because of erosive tissue necrosis (melting) around the margin of the prosthesis.…”

“…6,10 Since the 1990s, a new generation of experimental KPros have been developed to solve the complications associated with the existing prostheses by increasing their hydrophilicity and flexibility to stimulate biocolonization of host cells on the peripheral part of the prosthesis, and consequently improve their biocompatibility. 5,9 Chirila KPro or AlphaCor ™ (Addition Technology Inc, Des Plaines, IL), one of the recent Food and Drug Administration (FDA) -approved keratoprostheses, is an artificial device consisting of a homogeneous spongy peripheral skirt and a transparent central part. Both parts are made from poly-2-hydroxyethyl methacrylate.…”