1983
DOI: 10.1055/s-2007-1005028
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Development and Clinical Use of Automated Synthetic Substrate Methods for the Evaluation of Coagulation and Fibrinolysis

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Cited by 3 publications
(3 citation statements)
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“…The within-and betweenassay variation decreases 1 % to 4% in com parison with the manual method. These re sults are in complete agreement with the results of other investigators [5,[14][15][16]. The linearity of the various assays is for AT III from 5 to 150%; for factor X from 5 to 200%; for plasminogen from lOto 125%and for cu-AP from 10 to 150% of standard ref erence plasma ( fig.…”
Section: Discussionsupporting
confidence: 92%
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“…The within-and betweenassay variation decreases 1 % to 4% in com parison with the manual method. These re sults are in complete agreement with the results of other investigators [5,[14][15][16]. The linearity of the various assays is for AT III from 5 to 150%; for factor X from 5 to 200%; for plasminogen from lOto 125%and for cu-AP from 10 to 150% of standard ref erence plasma ( fig.…”
Section: Discussionsupporting
confidence: 92%
“…From these intraindividual coefficients of variation, the biological coef ficient of variations can be calculated with the formula CV2to, = CV2assaj, + CV2bioi (ta ble IV) [22], With this biological coefficient of variation it is possible to calculate how much a future result may differ from pre vious values before there is any pathology. There is agreement with several published reports in which normal methods have been adapted to automated instruments [13,15,16,[23][24][25]. Since sample dilution, reagent consistency and precision in reagent han dling are best performed with an automated method, the performance characteristics of this instrument utilizing substrate-based methods are outstanding.…”
Section: Discussionsupporting
confidence: 86%
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