Clinical Neuroembryology 2014
DOI: 10.1007/978-3-642-54687-7_9
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Development and Developmental Disorders of the Forebrain

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Cited by 8 publications
(2 citation statements)
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“…Mutations in morphogenes can cause vast developmental defects, whereas mutations in TFs lead to more subtle phenotypes. Holoprosencephaly (HPE) is a multietiological NDD that serves as an example of an NDD where a disruption of a basic neurodevelopmental plan leads to observable brain and craniofacial malformations ( ten Donkelaar et al, 2014b ). Mutations of the SHH signaling pathway and FGF8 gene are commonly found in patients with HPE ( Dubourg et al, 2016 ; Roessler et al, 2018 ).…”
Section: Clinical Importance Of Stnmentioning
confidence: 99%
See 1 more Smart Citation
“…Mutations in morphogenes can cause vast developmental defects, whereas mutations in TFs lead to more subtle phenotypes. Holoprosencephaly (HPE) is a multietiological NDD that serves as an example of an NDD where a disruption of a basic neurodevelopmental plan leads to observable brain and craniofacial malformations ( ten Donkelaar et al, 2014b ). Mutations of the SHH signaling pathway and FGF8 gene are commonly found in patients with HPE ( Dubourg et al, 2016 ; Roessler et al, 2018 ).…”
Section: Clinical Importance Of Stnmentioning
confidence: 99%
“…Mutations of the SHH signaling pathway and FGF8 gene are commonly found in patients with HPE ( Dubourg et al, 2016 ; Roessler et al, 2018 ). In a chapter about induction and patterning of the forebrain, we discussed the complex spatiotemporal expression patterns of these morphogens, which could account for the great variability of the clinical phenotypes of HPE ( ten Donkelaar et al, 2014b ; Diaz and Puelles, 2020 ). On the other hand, cognitive impairments caused by mutations in FOXP1 and FOXP2 genes are perceived as neurobehavioral disorders, or NDDs in a “broader sense” ( ten Donkelaar et al, 2014a ).…”
Section: Clinical Importance Of Stnmentioning
confidence: 99%