Alzheimer’s disease, being a chronic state progressive ND(neurodegenerative diseases), is characterised by abnormalities beta-amyloid and impaired cognitive functions resulting in dementia. Exosomes (Nano-particles) have developed as a promising mediators of NDs in which they carry toxic particles between cells and transfer them. Hence, current review focusesprimarily on the effects of exosomes in modulating mediators and promotingneuroprotection against NDs.