Development and estimation of a novel cryoprobe utilizing the Peltier effect for precise and safe cryosurgery

Takeda, H.; Maruyama, Shigenao; Okajima, Junnosuke; Aiba, S.; Komiya, Atsuki

doi:10.1016/j.cryobiol.2009.08.004

Cited by 36 publications

(10 citation statements)

References 13 publications

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“…Rapid temperature control. The temperature control of the upper and lower boundaries is conducted by a single computer-driven PID system, enabling temperature stability of ±0.01 K. Takeda et al 48 used a similar PID setup in a cryoprobe that is used in safe and reliable cryosurgery. The temperature at the copper/liquid boundaries inside the Soret cell is measured by T-type thermocouples.…”

Section: Soret Cellmentioning

confidence: 99%

“…Coolant exchangers are preferable as a heat sink for large temperature differences or a long experimental time. 19 The use of liquid nitrogen as a heat sink is the best choice for temperatures lower than 0 • C. 48 In this set of experiments, standard fins were employed since the temperature ranges inside the cell are within ±5 • C of the room temperature T room and the experimental time is within a couple of hours. The use of fins as heat sink provides a simple setup without moving components that might …”

Section: Soret Cellmentioning

confidence: 99%

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Measurement of Soret and Fickian diffusion coefficients by orthogonal phase-shifting interferometry and its application to protein aqueous solutions

Torres

Komiya

Henry

et al. 2013

The Journal of Chemical Physics

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We have developed a method to measure thermodiffusion and Fickian diffusion in transparent binary solutions. The measuring instrument consists of two orthogonally aligned phase-shifting interferometers coupled with a single rotating polarizer. This high-resolution interferometer, initially developed to measure isothermal diffusion coefficients in liquid systems [J. F. Torres, A. Komiya, E. Shoji, J. Okajima, and S. Maruyama, Opt. Lasers Eng. 50, 1287 (2012)], was modified to measure transient concentration profiles in binary solutions subject to a linear temperature gradient. A convectionless thermodiffusion field was created in a binary solution sample that is placed inside a Soret cell. This cell consists of a parallelepiped cavity with a horizontal cross-section area of 10 × 20 mm(2), a variable height of 1-2 mm, and transparent lateral walls. The small height of the cell reduces the volume of the sample, shortens the measurement time, and increases the hydrodynamic stability of the system. An additional free diffusion experiment with the same optical apparatus provides the so-called contrast factors that relate the unwrapped phase and concentration gradients, i.e., the measurement technique is independent and robust. The Soret coefficient is determined from the concentration and temperature differences between the upper and lower boundaries measured by the interferometer and thermocouples, respectively. The Fickian diffusion coefficient is obtained by fitting a numerical solution to the experimental concentration profile. The method is validated through the measurement of thermodiffusion in the well-known liquid pairs of ethanol-water (ethanol 39.12 wt.%) and isobutylbenzene-dodecane (50.0 wt.%). The obtained coefficients agree with the literature values within 5.0%. Finally, the developed technique is applied to visualize biomolecular thermophoresis. Two protein aqueous solutions at 3 mg∕ml were used as samples: aprotinin (6.5 kDa)-water and lysozyme (14.3 kDa)-water. It was found that the former protein molecules are thermophilic and the latter thermophobic. In contrast to previously reported methods, this technique is suitable for both short time and negative Soret coefficient measurements.

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Section: Soret Cellmentioning

confidence: 99%

Section: Soret Cellmentioning

confidence: 99%

Measurement of Soret and Fickian diffusion coefficients by orthogonal phase-shifting interferometry and its application to protein aqueous solutions

Torres

Komiya

Henry

et al. 2013

The Journal of Chemical Physics

Self Cite

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“…We derived the thermal penetration depth of biological tissue, which is the limit of depth to which the heat effect can reach when the body surface is heated or cooled, from bioheat transfer theory [5]. Additionally, we have developed cooling equipment for the brain to diagnose brain functioning [6] and a cryoprobe with high controllability of heat transfer [7]. The objective of this study was the quantitative analysis of the effects of moxibustion therapy using engineering techniques.…”

Section: Introductionmentioning

confidence: 99%

Thermal therapy and evaluation by a precise temperature control device

Maruyama

Takashima

Okajima

et al. 2011

Heat Trans. Asian Res.

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Moxibustion, one of the thermal therapies used in oriental medicine, has several problems, including the fact that temperature distribution over a treatment region is not uniform, the treatment temperature cannot be controlled, and smoke is emitted. To solve these problems, we developed a precise thermal heat transfer control device and applied it to clinical medicine as a substitute for conventional moxibustion. The abdominal heating controller developed in this study has an effect equal to that of moxibustion and can heat the treatment region of human skin uniformly. The treatment effect of the device was evaluated in a clinical experiment, in which we found that these devices can treat ileus, diarrhea, and related disorders. We sought the optimal temperature for thermal therapy with regard to gender, body mass index, and age. We carried out a numerical simulation of temperature distribution inside a human body when the abdominal region is heated. Temperature distribution of the heated abdominal region was calculated using a 2-D axisymmetric model considering bioheat generation such as blood perfusion and metabolism. The calculation results confirmed that the thermal effect cannot reach the viscera.

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“…Several cryoprobes have been proposed that reduce the level of invasiveness. Takeda et al [7] developed a Peltier cryoprobe. By changing the electric current supplied to a Peltier module, the surface temperature of the cooling section can be controlled precisely.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Characteristics of Phase Change Heat Transfer in Ultrafine Cryoprobe

Okajima¹,

Komiya²,

Maruyama³

2014

JFCMV

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To reduce the invasiveness of cryosurgery, a miniaturized cryoprobe is necessary. The authors have developed an ultrafine cryoprobe for realizing low-invasive cryosurgery by local freezing. The objectives of this study are to estimate the heat transfer coefficient and investigate the characteristics of the phase change heat transfer in the ultrafine cryoprobe. This cryoprobe has a double-tube structure consisting of two stainless steel microtubes. The outer diameter of the cryoprobe was 550 μm. The alternative Freon HFC-23, which has a boiling point of −82˚C at 0.1 MPa, was used as a refrigerant. To evaluate the characteristics of boiling flow in the cryoprobe, the heat transfer coefficient was estimated. The derived heat transfer coefficient was higher than that obtained from the conventional correlation. Additionally, a bubble expansion model was introduced to evaluate the heat transfer mode of the phase change flow in the ultrafine cryoprobe. This model can estimate the liquid film thickness during the expansion of a single bubble in a microchannel. The experimentally measured wall superheat was much lower than that obtained from the model. Therefore, this result also implied that the heat transfer mode in the ultrafine cryoprobe should be nucleate boiling.

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Development and estimation of a novel cryoprobe utilizing the Peltier effect for precise and safe cryosurgery

Cited by 36 publications

References 13 publications

Measurement of Soret and Fickian diffusion coefficients by orthogonal phase-shifting interferometry and its application to protein aqueous solutions

Measurement of Soret and Fickian diffusion coefficients by orthogonal phase-shifting interferometry and its application to protein aqueous solutions

Thermal therapy and evaluation by a precise temperature control device

Evaluation of Characteristics of Phase Change Heat Transfer in Ultrafine Cryoprobe

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