Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training

Grab, Maximilian; Hopfner, Carina; Gesenhues, Alena; König, Fabian; Haas, Nikolaus A.; Hagl, Christian; Curta, Adrian; Thierfelder, Nikolaus

doi:10.3791/62063

Cited by 9 publications

(2 citation statements)

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“…However, the growing interest and importance of the combination of the above mentioned technologies for the future of interventional cardiac surgery and the imaging of cardiovascular function in the form of virtual twins puts the subject at the centre of interest for engineers and clinicians alike [82]. In addition to preventive medicine or bespoke cardiac interventions, this includes regenerative surgery in the form of the emerging possibility of 3D printing tissues from bio-ink (in most cases: the patient's stem cells) through reverse engineering (3D scan -modification -3D printing) [26,93]. We are already able to print other human tissues, such as skin (innervated and vascularised), but larger and more complex organs such as the pancreas, liver, lungs or just the heart have so far been beyond our reach.…”

Section: Introductionmentioning

confidence: 99%

Most Current Solutions using Virtual-Reality-Based Methods in Cardiac Surgery -- A Survey

Mikolajewski,

Bryniarska,

Wilczek

et al. 2024

csci

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There is a widespread belief that VR technologies can provide controlled, multi-sensory, interactive 3D stimulus environments that engage patients in interventions and measure, record and motivate required human performance. In order to investigate state-of-the-art and associated occupations we provided a careful review of 6 leading medical and technical bibliometric databases. Despite the apparent popularity of the topic of VR use in cardiac surgery, only 47 articles published between 2002 and 2022 met the inclusion criteria. Based on them VR-based solutions in cardiac surgery are useful both for medical specialists and for the patients themselves. The new lifestyle required from cardiac surgery patients is easier to implement thanks to VR-based educational and motivational tools. However, it is necessary to develop the above-mentioned tools and compare their effectiveness with Augmented Reality (AR). With the aforementioned reasons, interdisciplinary collaboration between scientists, clinicians and engineers is necessary.

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Section: Introductionmentioning

confidence: 99%

Most Current Solutions using Virtual-Reality-Based Methods in Cardiac Surgery -- A Survey

Mikolajewski,

Bryniarska,

Wilczek

et al. 2024

csci

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“…3D printed models provide unparalleled capacity to recapitulate the highly complex and dynamic microenvironment of various tissues and, therefore, have found increasing applications in modeling a variety of congenital heart disease ( 25 – 27 ). The creation of patient-specific anatomical 3D models has been shown to be a greatly effective tool in cardiac interventional planning and medical education ( 28 ). Notably, techniques in additive manufacturing and fluid dynamic analysis have been previously used to study pulmonary artery atresia (PAA) and tetralogy of Fallot (TOF) with major aortopulmonary collateral arteries (MAPCAs) by the creation of simplified perfusable phantom models and subsequent CFD and PIV analyses ( 29 ).…”

Section: Introductionmentioning

confidence: 99%

Patient-specific 3D in vitro modeling and fluid dynamic analysis of primary pulmonary vein stenosis

Devlin,

Tomov,

Chen

et al. 2024

Front. Cardiovasc. Med.

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IntroductionPrimary pulmonary vein stenosis (PVS) is a rare congenital heart disease that proves to be a clinical challenge due to the rapidly progressive disease course and high rates of treatment complications. PVS intervention is frequently faced with in-stent restenosis and persistent disease progression despite initial venous recanalization with balloon angioplasty or stenting. Alterations in wall shear stress (WSS) have been previously associated with neointimal hyperplasia and venous stenosis underlying PVS progression. Thus, the development of patient-specific three-dimensional (3D) in vitro models is needed to further investigate the biomechanical outcomes of endovascular and surgical interventions.MethodsIn this study, deidentified computed tomography images from three patients were segmented to generate perfusable phantom models of pulmonary veins before and after catheterization. These 3D reconstructions were 3D printed using a clear resin ink and used in a benchtop experimental setup. Computational fluid dynamic (CFD) analysis was performed on models in silico utilizing Doppler echocardiography data to represent the in vivo flow conditions at the inlets. Particle image velocimetry was conducted using the benchtop perfusion setup to analyze WSS and velocity profiles and the results were compared with those predicted by the CFD model.ResultsOur findings indicated areas of undesirable alterations in WSS before and after catheterization, in comparison with the published baseline levels in the healthy in vivo tissues that may lead to regional disease progression.DiscussionThe established patient-specific 3D in vitro models and the developed in vitro–in silico platform demonstrate great promise to refine interventional approaches and mitigate complications in treating patients with primary PVS.

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Bioengineering of Pediatric Cardiovascular Constructs: In Vitro Modeling of Congenital Heart Disease

Bauser‐Heaton

Gil

Serpooshan

2022

Advanced Technologies in Cardiovascular Bioengineering

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Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training

Cited by 9 publications

References 0 publications

Most Current Solutions using Virtual-Reality-Based Methods in Cardiac Surgery -- A Survey

Most Current Solutions using Virtual-Reality-Based Methods in Cardiac Surgery -- A Survey

Patient-specific 3D in vitro modeling and fluid dynamic analysis of primary pulmonary vein stenosis

Bioengineering of Pediatric Cardiovascular Constructs: In Vitro Modeling of Congenital Heart Disease

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