Development and evaluation of 5-fluorouracil loaded chitin nanogels for treatment of skin cancer

Sabitha, M.; Rejinold, N. Sanoj; Nair, Amrita; Lakshmanan, Vinoth-Kumar; Nair, Shantikumar V.; Jayakumar, R.

doi:10.1016/j.carbpol.2012.07.060

Cited by 109 publications

(54 citation statements)

References 35 publications

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“…The results obtained in this study confirmed that 5-fluorouracil does result in apoptotic cell death and is effective against human melanoma (A375) cells. In a previous study, 5-fluorouracil loaded chitin nanogels resulted in only a mild cytotoxic effect against A375 cells after a 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay (14). This further demonstrates the proposition that the apoptosis-inducing effect of 5-fluorouracil seems to differ according to the vehicle that the API has been incorporated into.…”

Section: Drug Efficacy Testingmentioning

confidence: 73%

“…Due to the unfavorable skin permeation profile of 5-fluorouracil in conventional formulations, there has been an increased interest in the use of drug delivery systems to deliver 5-fluorouracil into the deeper layers of the skin. Research has been carried out on the topical delivery of 5-fluorouracil using drug delivery systems such as ethosomes (12) niosomes, liposomes, transfersomes (13), and nanogels (14). In these studies, it showed that the drug delivery systems resulted in an increase in either the flux or retention of API in the skin layers.…”

Section: Introductionmentioning

confidence: 99%

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Topical Delivery of 5-Fluorouracil from Pheroid™ Formulations and the In Vitro Efficacy Against Human Melanoma

et al. 2015

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Abstract. Drug delivery vehicles can influence the topical delivery and the efficacy of an active pharmaceutical ingredient (API). In this study, the influence of Pheroid™ technology, which is a unique colloidal drug delivery system, on the skin permeation and antimelanoma efficacy of 5-fluorouracil were investigated. Lotions containing Pheroid™ with different concentrations of 5-fluorouracil were formulated then used in Franz cell skin diffusion studies and tape stripping. The in vitro efficacy of 5-fluorouracil against human melanoma cells (A375) was investigated using a flow cytometric apoptosis assay. Statistically significant concentrations of 5-fluorouracil diffused into and through the skin with Pheroid™ formulations resulting in an enhanced in vitro skin permeation from the 4.0% 5-fluorouracil lotion (p<0.05). The stratum corneum-epidermis and epidermis-dermis retained 5-fluorouracil concentrations of 2.31 and 6.69 μg/ml, respectively, after a diffusion study with the 4.0% Pheroid™ lotion. Subsequent to the apoptosis assay, significant differences were observed between the effect of 13.33 μg/ml 5-fluorouracil in Pheroid™ lotion and the effects of the controls. The results obtained suggest that the Pheroid™ drug delivery system possibly enhances the flux and delivery of 5-fluorouracil into the skin. Therefore, using Pheroid™ could possibly be advantageous with respect to topical delivery of 5-fluorouracil.

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Section: Drug Efficacy Testingmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Topical Delivery of 5-Fluorouracil from Pheroid™ Formulations and the In Vitro Efficacy Against Human Melanoma

et al. 2015

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“…␣ -Chitin solution (0.5%) was prepared according to reported method [20]. For the preparation of chitin-PCL CNGs, 10 mL of the chitin solution was taken in a beaker and stirred on a magnetic stirrer for 1 h to ensure complete uniformity.…”

Section: Preparation Of Chitin-pcl Cngsmentioning

confidence: 99%

Doxorubicin-chitin-poly(caprolactone) composite nanogel for drug delivery

Arunraj

Rejinold

Kumar

et al. 2013

International Journal of Biological Macromolecules

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“…With constant progression in the field of science and technology, the need to address the practical problems associated with the drug therapies increased proportionately. Cutaneous melanoma is the most violent skin cancer, accounting for 75% of all deaths [3]. …”

Section: Introductionmentioning

confidence: 99%

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Rai¹,

Pandey²,

Rai³

2017

Nano Reviews & Experiments

208

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Introduction: The skin acts as a barrier and prevents transcutaneous delivery of therapeutic agents. Transfersomes are novel vesicular systems that are several times more elastic than other vesicular systems. These are composed of edge activator, phospholipids, ethanol, and sodium cholate and are applied in a non-occlusive manner. Areas covered: This article covers information such as merits/demerits of transfersomes, regulatory aspects of materials used in preparation, different methods of preparation, mechanism of action, review of clinical investigations performed, marketed preparations available, research reports, and patent reports related to transfersomes. Expert opinion: Research over the past few years has provided a better understanding of transfersomal permeation of therapeutic agents across stratum corneum barrier. Transfersomes provides an essential feature of their application to variety of compositions in order to optimize the permeability of a range of therapeutic molecules. This is evidenced by the fact that there are several Transfersome products being processed in advanced clinical trials. It is noteworthy that a number of Transfersome products for dermal and transdermal delivery will gain a global market success in near future.

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Development and evaluation of 5-fluorouracil loaded chitin nanogels for treatment of skin cancer

Cited by 109 publications

References 35 publications

Topical Delivery of 5-Fluorouracil from Pheroid™ Formulations and the In Vitro Efficacy Against Human Melanoma

Topical Delivery of 5-Fluorouracil from Pheroid™ Formulations and the In Vitro Efficacy Against Human Melanoma

Doxorubicin-chitin-poly(caprolactone) composite nanogel for drug delivery

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

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