Development and Evaluation of a New Fluorinated Double-Wall Carbon Nanotube HPLC Stationary Phase

André, Carl; Aljhni, Rania; Lethier, Lydie; Guillaume, Yves Claude

doi:10.1007/s10337-014-2736-3

Cited by 14 publications

(6 citation statements)

References 45 publications

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“…To the authors' best knowledge, only one paper is presently available in the literature reporting on reversed-phase LC based whose specific adsorption and selectivity are strictly imparted by the CNT functional groups. Specifically, fluorinated double-walled CNTs were immobilized onto silica to combine the analytical performance of CNTs and the unique selectivity of fluorine based compounds for polar substances (André et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Tuning retention and selectivity in reversed-phase liquid chromatography by using functionalized multi-walled carbon nanotubes

Speltini

Profumo

Merli

et al. 2019

Arabian Journal of Chemistry

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Aim of this work is to explore the possibility of retention and selectivity tuning in reversed-phase liquid chromatography by means of chemically modified multi-walled carbon nanotubes (MWCNTs). These were synthesized by derivatizing pristine MWCNTs with amino-terminated alkyl chains containing polar embedded groups. A novel hybrid material based on functionalized MWCNTs (MWCNTs-R-NH 2 ) was prepared, characterized and tested. The idea was to dispose of a mixed-mode separation medium basing its sorption properties on the peculiar characteristics of MWCNTs combined with the chemical interactions provided by the functional chains introduced on the nanotube skeleton. MWCNTs-R-NH 2 were easily grafted to silica microspheres by gamma radiation (using a 60 Co source) in the presence of polybutadiene as the linking agent. The composite was characterized by scanning electron microscopy (SEM) and Brunauer, Emmett and Teller (BET) analysis in terms of structural morphology, surface area and porosity. The MWCNTs-R-NH 2 sorbent was tested as stationary phase. The reversed-phase behaviour was first proved by analysis of alkylbenzenes, while the key role of CNT derivatization in addressing the selectivity/affinity towards the solutes was evidenced by testing three classes of analytes, viz. barbiturates, steroid hormones and alkaloids. These compounds, with different molecular structure and polarity, were here analyzed for the first time on CNT-based LC stationary phases. The behaviour of the novel sorbent was compared in terms of retention capability and resolution with that observed using unmodified MWCNTs, pointing out the mixedmode characteristics of the MWCNTs-R-NH 2 material. The same test mixtures were analyzed also on a 3 conventional mono-modal separation sorbent (C18) to highlight the particular behaviour of the (derivatized)MWCNTs-based stationary phases. The novel material showed better performance in separation of polar compounds, i.e. barbiturates and alkaloids, than the unmodified MWCNTs and than the C18 column. Results showed that MWCNT functionalization is powerful to modulate retention/selectivity in reversed-phase liquid chromatography.

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Section: Introductionmentioning

confidence: 99%

Tuning retention and selectivity in reversed-phase liquid chromatography by using functionalized multi-walled carbon nanotubes

Speltini

Profumo

Merli

et al. 2019

Arabian Journal of Chemistry

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“…Over the years, major advancements in fluorinated stationary phases have been made such as pentafluorophenyl (PFP) phase [12][13][14] with the unique characteristics of fluorine atoms including high electronegativity, low polarizability, strong hydrophobicity, and good thermal and chemical stability [15]. In addition to dispersive interactions that traditional alkyl phases have, the PFP phase also provides enhanced dipole-dipole, pi-pi, charge transfer, and ion-exchange interactions [16].…”

Section: Introductionmentioning

confidence: 99%

High‐performance liquid chromatography quantitative analysis of ephedrine alkaloids in Ephedrae Herba on a perfluorooctyl stationary phase

Song

Jin

et al. 2022

J of Separation Science

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Ephedrae Herba is one of the most commonly used herbal medicines, and it has been shown that most of the clinical efficacy for cold and asthma is exerted by its alkaloidal components. A simple and sensitive high‐performance liquid chromatography method was developed using a perfluorooctyl column for the simultaneous determination of five alkaloids (norephedrine, norpseudoephedrine, ephedrine, pseudoephedrine, and methylephedrine) in Ephedrae Herba. The mobile phase comprising acetonitrile and 15 mM ammonium trifluoroacetate was used to elute the targets in isocratic elution mode. The method was validated for linearity (R2 > 0.999), repeatability, intraday and interday precision, recoveries with trueness (93.87–110.99%), limits of detection (5.35–5.76 µg/mL), and limits of quantification (20 µg/mL). The quantitative results revealed that the developed method was precise and accurate. Then it was successfully applied to determine the difference in the contents of three batches of Ephedrae Herba from three pharmaceutical companies.

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“…Fluorinated RPLC stationary phase has been demonstrated to offer alternative selectivity from conventional RPLC stationary phases [20][21][22]. In particular, basic compounds were more strongly retained than neutral compounds on the fluorinated RPLC stationary phase [23].…”

Section: Introductionmentioning

confidence: 99%

A strategy for efficient enrichment of steroidal alkaloids from Fritillaria based on fluorinated reversed‐phase stationary phase

Zhou

et al. 2021

J of Separation Science

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Plant-derived alkaloids are bioactive natural ingredients, but their contents are relatively low in plants. Therefore, the efficient enrichment of alkaloids is a prerequisite for purification and further pharmacological research. In this study, an efficient and simple strategy for enrichment of steroidal alkaloids in Fritillaria was developed for the first time based on the fluorinated reverse-phase stationary phase (FC8HL). Superior selectivity between alkaloids and non-alkaloids was achieved in a non-aqueous system, and a simple solvent system containing low-

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Development and Evaluation of a New Fluorinated Double-Wall Carbon Nanotube HPLC Stationary Phase

Cited by 14 publications

References 45 publications

Tuning retention and selectivity in reversed-phase liquid chromatography by using functionalized multi-walled carbon nanotubes

Tuning retention and selectivity in reversed-phase liquid chromatography by using functionalized multi-walled carbon nanotubes

High‐performance liquid chromatography quantitative analysis of ephedrine alkaloids in Ephedrae Herba on a perfluorooctyl stationary phase

A strategy for efficient enrichment of steroidal alkaloids from Fritillaria based on fluorinated reversed‐phase stationary phase

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