Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery

Zhang, Jifen; Tang, Qin; Xu, Xiaoyu; Li, Na

doi:10.1016/j.ijpharm.2013.03.021

Cited by 162 publications

(85 citation statements)

References 30 publications

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“…The encapsulation efficiency was 92.83 ± 0,520 % which is in accordance with other methods of production of phyto-phospholipidic particles 9 .…”

Section: Encapsulation Efficiency Of Optimized Formulationsupporting

confidence: 88%

“…The first reports of phyto-phospholipid complex preparation used essentially organic aprotic solvents as dichloromethane, or dioxane as the reaction medium-8 catalase and thiobarbituric acid reactive substances with respect to carbon tetrachloride treated group (P < 0.05 and <0.01. Those harmful solvents have been progressively substituted by less toxic solvents as acetone or ethanol 9 . The phytosomes were generally obtained…”

Section: Introductionmentioning

confidence: 99%

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Plectranthus madagascariensis phytosomes: formulation optimization

Matias¹,

Roque²,

Simões³

et al. 2015

BBR

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Biopharmaceutical Sciences│Ciências BiofarmacêuticasBiomed Biopharm Res. , 2015; (12) 2: , 223-231 223 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Plectranthus madagascariensis phytosomes: formulation optimization AbstractMedicinal plants have been a reliable source of bioactive natural products with potential pharmaceutical applications. The delivery of those bioactive agents into nanosystems is considered a promising strategy for the optimization of their pharmacologic effects. This work describes the preparation of phytosomes containing a bioactive extract from Plectranthus madagascariensis and optimization of the preparation method. Different formulations and process parameters were studied. It was observed that smaller and more uniform particles were obtained using acetone as solvent, a reaction time of two hours, and the addition of 2.5% molar concentration of cholesterol. The optimally prepared phytosomes had a diameter of 191.3 ± 75.3 nm with a polydispersity index of 0.243 ± 0.18, and a spherical shape with amorphous appearance. These nanosystems were able to encapsulate 92.8% of the extract, as evaluated by HPLC, relative to 7α,6β-dihydroxyroyleanona, the main extract component. This study suggests a future application of those phytosomes in the delivery of bioactive agents with therapeutic interest.Keywords: Phytosome, Plectranthus, Lamiaceae, Diterpenes, Formulation optimization ResumoAs plantas medicinais são uma fonte interessante de produtos naturais bioactivos com potenciais aplicações farmacêuticas. A veiculação destes agentes bioactivos em nanossistemas é considerada uma estratégia promissora para a optimização dos seus efeitos farmacológicos. O objectivo deste trabalho incide na preparação de fitossomas contendo um extracto bioactivo de Plectranthus madagascariensis e a sua optimização no método de preparação. Foram estudados vários parâmetros de formulação e processo. Observou-se que partículas menores e mais uniformes foram obtidas utilizando acetona como solvente, um período de reacção de 2h e com a adição do colesterol a uma concentração molar de 2,5%. Os fitossomas apresentaram um diâmetro de 191,3 ± 75,3 nm e com um índice de polidispersividade de 0,243 ± 0,18. Os fitossomas apresentaram uma forma esférica mas com aspecto amorfo. Estes nanossistemas foram capazes de encapsular 92,8% do extracto avaliado por HPLC em relação ao composto 7α,6β-dihidroxi-roileanona, o principal composto do extracto. Este estudo sugere uma futura aplicação destes fitossomas na veiculação de agentes bioactivos com interesse terapêutico.

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“…The encapsulation efficiency was 92.83 ± 0,520 % which is in accordance with other methods of production of phyto-phospholipidic particles 9 .…”

Section: Encapsulation Efficiency Of Optimized Formulationsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Plectranthus madagascariensis phytosomes: formulation optimization

Matias¹,

Roque²,

Simões³

et al. 2015

BBR

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“…In vitro curcumin release from Cur-PS-CMs was slower than that from curcumin-loaded chitosan microspheres (Cur-CMs) in pH 1.0, 4.0, 6.8, and 7.4 showing 1.67 and 1.07-fold increase in absorption of curcumin compared with Cur-PSs and Cur-CMs, respectively. The half-life of orally administered Cur-PS-CMs was longer than those of Cur-PSs and Cur-CMs by ~2 and 1.5-times, respectively, confirming oral absorption with prolonged retention time for sustained delivery of lipophilic compounds [240]. The MMC-soybean phosphatidylcholine complex-loaded PEG-lipid-PLA hybrid NPs were reported with Folate functionalization (FA-PEG-PE-PLA NPs@MMC-SPC) for targeted drug delivery and dual-controlled drug release involving hydrophobic core (PLA) loaded with MMC-SPC, an amphiphilic lipid interface layer (PE), a hydrophilic shell (PEG), and a targeting ligand (FA) on the surface, with a spherical shape, and high encapsulation efficiency (95%).…”

Section: Phytosomal Nanoparticulate Materialsmentioning

confidence: 67%

Green Intelligent Nanomaterials by Design (Using Nanoparticulate/2D-Materials Building Blocks) Current Developments and Future Trends

Kumar¹,

Ahmad²

2017

Nanoscaled Films and Layers

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Feasibility of designing and synthesizing 'smart' and 'intelligent' materials using nanostructured building blocks has been examined here based on the current status of the progress made in this context. The added advantages of using 2D layered/nonlayered materials along with phytosomal species derived from natural plants are highlighted with special reference to their better programmability along with minimum toxicity in biomedical applications. The current developments taking place in their upscaled productions are also included while assessing their upcoming industrial usages in diverse fields.

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“…The entrapment efficiency was calculated according to the following formula: [15][16] Entrapment efficiency (%) = (Total amount of drug) -(Amount of free drug) / (Total amount of drug) × 100…”

Section: Drug Entrapment Efficiencymentioning

confidence: 99%

Formulation and Evaluation of Capsules of Syzygium Cumini Phytosomes

Amudha¹,

Manna²,

Jeganathan³

2018

J. Pharm. Sci. Innov.

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The objective of the study was to develop a novel Phytosome formulation of Syzygium cumini capsules by incorporation of phospholipids, for the improved permeability, solubility and better physical characteristics. The Syzygium cumini phytosome capsules were prepared by using Thin Film Hydration Technique method and were optimized. The formations of phytosomes were analyzed for microscopic view, SEM, TEM, measurement of particle size & zeta potential, drug entrapment efficiency, drug content, In vitro dissolution studies and also the release kinetics of Syzygium cumini phytosomes complex. The Syzygium cumini phytosome capsules prepared by using Thin Film Hydration Technique showed a good microscopic view and practical yield, the drug content, SEM, TEM, measurement of particle size & zeta potential and other in vitro studies were resulted as anticipated. The Syzygium cumini phytosome capsules were found to show better solubility and compatibility with the excipients, it is concluded that Syzygium cumini extract phytosomes has better physical characteristics and improved permeability, solubility than that of extract to overcome ability to cross lipid-rich biological membranes and which results in increase oral bioavailability.

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Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery

Cited by 162 publications

References 30 publications

Plectranthus madagascariensis phytosomes: formulation optimization

Plectranthus madagascariensis phytosomes: formulation optimization

Green Intelligent Nanomaterials by Design (Using Nanoparticulate/2D-Materials Building Blocks) Current Developments and Future Trends

Formulation and Evaluation of Capsules of Syzygium Cumini Phytosomes

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