Development and evaluation of an artificial membrane for determination of drug availability

Loftsson, Þorsteinn; Konráðsdóttir, Fífa; Másson, Már

doi:10.1016/j.ijpharm.2006.07.009

Cited by 47 publications

(26 citation statements)

References 25 publications

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“…Such aggregates have been detected in aqueous solutions by transmission electron microscopy (13). Studies have shown that the mean hydrodynamic radius of CD aggregates increases with increasing CD concentration and, thus, it is possible to estimate the increase in aggregate size by determining the drug flux through semi-permeable membranes of different molecular weight cutoff (MWCO) (12,13,21,28). Flux studies were applied to detect self-association or CD aggregate formation (Fig.…”

Section: Resultsmentioning

confidence: 99%

Carvedilol: Solubilization and Cyclodextrin Complexation: A Technical Note

et al. 2008

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Section: Resultsmentioning

confidence: 99%

Carvedilol: Solubilization and Cyclodextrin Complexation: A Technical Note

et al. 2008

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“…In the last several years attempts were made to develop reliable in vitro skin models such applying various approaches such as relying on the chromatographic methods (Hidalgo-Rodriguez et al, 2013), non-lipid based models i.e. silicone membranes (Loftsson et al, 2006;Oliveira et al, 2010;Oliveira et al, 2011;Ottaviani et al, 2006), as well as the lipid-based models able to serve as a tool in predicting the desired or undesired dermal absorption.…”

Section: Artificial In Vitro Skin Modelsmentioning

confidence: 99%

In vitro skin models as a tool in optimization of drug formulation

Flaten

Palac²,

Engesland

et al. 2015

European Journal of Pharmaceutical Sciences

182

135

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Abstract(Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the product development. A rational approach in designing and optimizing skin formulations requires well-defined skin models, able to identify and evaluate the intrinsic properties of the formulation. Most of the current optimization relies on the use of suitable ex vivo animal/human models.However, increasing restrictions in use and handling of animals and human skin stimulated the search for suitable artificial skin models. This review attempts to provide an unbiased overview of the most commonly used models, with emphasis on their limitations and advantages. The choice of the most applicable in vitro model for the particular purpose should be based on the interplay between the availability, easiness of the use, cost and the respective limitations.

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“…Membranes obtained from diverse sources, such as synthetic [43,50,51], vegetable [52], human [53,33,43], animal [43,54] and reconstructed tissues [43,45,47] can be evaluated as candidates to predict the transport of substances across the skin and used during in vitro experiments. The advantages and disadvantages of these membrane models need to be investigated regarding their effectiveness to determine the transport of substances across the skin [26].…”

Section: Sources Of Membranesmentioning

confidence: 99%

Transport of Substances and Nanoparticles across the Skin and in Vitro Models to Evaluate Skin Permeation and/or Penetration

Contri

Fiel

Pohlmann

et al. 2011

Nanocosmetics and Nanomedicines

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Abstract. Nanotechnology can be used to modify the drug permeation/penetration of encapsulated substances, through the manipulation of many different factors, including direct contact with the skin surface and controlled release. In general, nanoparticles cannot cross the skin barrier, which can be explained by the cell cohesion and lipids of the stratum corneum, the outermost skin layer. The device most commonly used to study the transport of substances and nanoparticles across the skin is the Franz vertical diffusion cell, followed by the substance quantification in the receptor fluid or determination of the amount retained in the skin. Microscopy techniques have also been applied in skin penetration or permeation experiments. This chapter will present the fundamental considerations regarding the transport of encapsulated substances and/or nanoparticles across the skin, the experimental models applied in these studies and a review of the main studies reported in the literature in order to allow the reader to gain insight into the current knowledge available in this area.

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Development and evaluation of an artificial membrane for determination of drug availability

Cited by 47 publications

References 25 publications

Carvedilol: Solubilization and Cyclodextrin Complexation: A Technical Note

Carvedilol: Solubilization and Cyclodextrin Complexation: A Technical Note

In vitro skin models as a tool in optimization of drug formulation

Transport of Substances and Nanoparticles across the Skin and in Vitro Models to Evaluate Skin Permeation and/or Penetration

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