Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Samadera indica for skin diseases

Viswanad, Vidya; Aleykutty, NA; Jayakar, B.; Zacharia, Subin Mary; Thomas, Litha

doi:10.4103/2231-4040.97285

Cited by 17 publications

(12 citation statements)

References 13 publications

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“…Other constituents were polymer Carbopol 940 (Gelling agent), Propyl Paraben and Methyl Paraben (Preservatives), Propylene Glycol 400 (Lubricant), Triethanolamine/TEA (pH and buffer adjusting agent) and water (Vehicle). 22,23 Gel was prepared by Dispersion method. Various physico-chemical parameters of gel were studied and the herbal gel was found light green in color, homogeneous, smooth, easily spreadable, with good extrudability and pH near to normal skin pH range.…”

Section: Discussionmentioning

confidence: 99%

Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia obliqua Topical Gel on Animal Model

Gupta¹

2017

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Background:The plants of genus Cordia has been used in traditional medicine for many diseases from history. Cordia obliqua Willd. is also a medicinally important plant and it has been proved by modern scientific research. Objective: This study is aimed to formulate and characterize a topical gel from Cordia obliqua leaf methanol extract and evaluate its effect on carrageenan induced rat paw edema. Materials and Methods: The methanol extract was prepared by successive solvent extraction using soxhlet apparatus. Topical gel was designed to prepare by Dispersion method using Carbopol 940 as polymer. The various gel characteristics was studied by standard procedures like Homogeneity, grittiness, extrudability, drug content, spread ability and in-vitro diffusion study. The anti-inflammatory potential of gel was evaluated by Carrageenan induced rat paw edema method in comparison with standard Diclofenac Sodium gel 1% on Albino rats. Results: The herbal gel was found homogeneous with good extrudability, no grittiness, pH 6.79 and drug content 93.167%. The anti-inflammatory activity of herbal gel was found comparable with standard Diclofenac Sodium gel and has shown 82.71% edema inhibition after 4 h of treatment. Conclusion: Cordia obliqua gel was found suitable as a standard topical gel formulation and it can be used safely for treatment of edema.

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Section: Discussionmentioning

confidence: 99%

Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia obliqua Topical Gel on Animal Model

Gupta¹

2017

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“…It was then kept in a hot air oven at 60°C for 24-48 h until it was dried completely, make it coarsely powdered and stored in a closed container for further use. [6][7][8]. S. indica is an evergreen tree or shrubs up to 10 m high with stout branches and pale yellow bark.…”

Section: Methodsmentioning

confidence: 99%

The Evaluation of the Wound Healing Properties of Methanolic Bark Extract of Samadera Indica Gaertner in Vivo

Bhat¹,

Pr²,

Rao³

2019

Asian J Pharm Clin Res

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Objectives: The exracts of Samadera indica used in traditional medicines for the treatment of skin diseases, rheumatism, cough and to kill head lice. The main objective of the present study was to evaluate the wound healing activity of methanolic bark extract of Samadera indica. Methods: The bark samples of were collected, allowed to shade dry for a week, then coarsely powdered and was extracted with methanol by soxhlation process. The extract was used for wound healing experiment using excision wound model. 18 healthy Wistar albino rats divided into three groups of six rats each with average body weight of 150-200 g were selected randomly for the study. ANOVA was used to compare the variation in the treatments in the result. The 1st group of animals are left as such for natural healing process as control, 2nd group of animals were treated with standard ointment betadien and 3rd group with the test drug methanolic bark ointment formulation. The methanolic extract in simple ointment base as mentioned above and betadien ointment were applied on the wound once a day for 16 days starting from the day of wounding. The percentage wound closure was observed on 4th, 8th, 12th and 16th post wounding day. Results: As for the group received methanolic bark extract for wound healing, fourth day wound mean diameter was 208.0±3.521, 8th day the wound mean diameter was 160.66±7.89, 12th day wound mean diameter was 87.5±5.8 and 16th day wound mean diameter was 22.5±5.12. Comparing to standard drug betadien the bark extract showed faster healing in terms of diameter of wound which was statistically signified. Conclusions: The results of the experiment revealed that there was marked decrease in wound diameter with every point of time the observation made indicating the effect of extract on progressive healing of wound. Samadera indica proved its wound healing potential of the plant extract which is due to the bioactive compounds and thus the study supports local folklore practitioners and tribal people for the use of plant in different ailments.

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“…The larger amount extruded the better extrudability. Extrudability was determined in terms of weight in grams required to extrude 0.5 cm of ribbon of ointment in 5 s [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies

et al. 2016

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The purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been acknowledged and exploited, it is clear that their use can be extended further to cover their antibacterial properties. In vitro evaluation showed that 20% (v/v) fatty acid extract exhibits good activity against strains of the Gram-positive bacteria Staphylococcus aureus, Enterococcus faecalis, Streptoccoccus pyogenes and Streptoccoccus pneumonia. Therefore, free polyunsaturated fatty acids from cod liver oil or other fish oils can be used as safe and natural antibacterial agents. In this study, ointment compositions containing free fatty acids as active antibacterial agents were prepared by using various natural waxes and characterized. The effects of different waxes, such as carnauba wax, ozokerite wax, laurel wax, beeswax, rice bran wax, candelilla wax and microcrystalline wax, in the concentration range of 1% to 5% (w/w) on the ointment texture, consistency and stability were evaluated. The results showed significant variations in texture, sensory and rheological profiles. This was attributed to the wax’s nature and chain composition. Microcrystalline wax gave the best results but laurel wax, beeswax and rice bran wax exhibited excellent texturing, similar sensory profiles and well-balanced rheological properties.

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Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Samadera indica for skin diseases

Cited by 17 publications

References 13 publications

Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia obliqua Topical Gel on Animal Model

Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia obliqua Topical Gel on Animal Model

The Evaluation of the Wound Healing Properties of Methanolic Bark Extract of Samadera Indica Gaertner in Vivo

Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies

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