Development and evaluation of antipsychotic drugs for externally triggered transdermal therapeutic systems

Abstract

Cariprazine is a recent antipsychotic drug with an atypical neuropharmacological profile. It is promptly absorbed from the GI tract and suddenly metabolized by liver. Cariprazine has 6 h of plasma elimination half life, 9% of oral and 83% of protein binding. Administration of cariprazine in transdermal dosage form would be a lot of fascinating to regulate the mood for extended period by achieving the plasma concentration well higher than the therapeutic levels. With psychiatrical patients, schedules of daily medication should be followed to avoid adverse reactions which are notably difficult. Therefore, delivery of such drugs by transdermal route can be done. Development and maintenance of low dose drugs therapy is desired, which will limit the consequences of significant adverse effect and direct the issues of helpless consistence in the patients. Ideal quantity of the psychotropic drug can be given by transdermal route with least adverse reactions to overcome the psychic conditions. This will result in improving the health care services for long term mental illness management. In present work, we have synthesized the novel electrically responsive graft co-polymers using natural polymers with polyacrylamide and utilized for the preparation of cariprazine containing electrically responsive transdermal therapeutic systems (ETTS).