Development and Evaluation of Antithrombogenic Centrifugal Pump: The Baylor C–Gyro Pump Eccentric Inlet Port Model

Abstract

The Baylor C-Gyro Pump Eccentric Inlet Port Models (C1E) have been developed aiming for a long-term centrifugal ventricular assist device (VAD) as well as a cardiopulmonary bypass pump. The eccentric inlet port models are characterized by their unique inlet port and secondary impeller vanes. An inlet female pivot bearing, which was fixed to a supporting bar in the prototype model, is directly embedded into the ceiling of the pump casing. An inlet port is then placed off-center to avoid the bearing area, and it is angled between 0 to 90 degrees from the upright position. In addition, small secondary vanes were incorporated into the impeller bottom to accelerate the washout flow behind the impeller. These features attained design objectives proposed for higher antithrombogenicity: a seal-less pump chamber, no stationary parts in the blood path, and acceleration of the secondary flow behind the impeller. The first in vivo experiment using C1E pumps showed excellent antithrombogenicity for up to 18 days when the experiment ceased due to severe infection in the calf.

Comparison of the Gyro C1E3 and BioMedicus Centrifugal Pump Performances During Cardiopulmonary Bypass

“…The specific features of a compact eccentric inlet port (ClE3) centrifugal blood pump for use as a multi-purpose centrifugal pump have been previously reported (3,4). As for the atraumatic aspects of its operation, the NIH value of this pump is comparable to those of other commercially available centrifugal pumps.…”

“…The impeller has 6 straight vanes on the top and 2 straight secondary vanes on the bottom. This pump has unique antithrombogenic features such as a sealless pump casing, a pivot bearing system at the top and bottom of the impeller, and acceleration of the secondary blood flow around the bottom bearing areas by secondary vanes (3)(4)(5). In addition, placing the inlet port in the off-center position eliminates stationary parts in the blood path.…”

“…This particular construction was developed to solve impeller shaft related problems for intermediate-term usage. This pump has demonstrated effective prevention of thrombus formation and leakage (3)(4)(5). In addition, to obtain a suitable rotating condition, the polyethylene female bearings have been embedded into the top and bottom.…”

Preclinical evaluation of the Kyocera Gyro centrifugal blood pump for cardiopulmonary bypass

“…[9][10][11][12] In the present study, we evaluated the feasibility of the Gyro Pump as a pump for CPB, comparing it with the BioMedicus Pump (BP-80, Medtronic BioMedicus, Inc., Edren Prairie, MN, USA), the most commonly used centrifugal pump.…”

Bomba sangüínea espiral: concepção, desenvolvimento e aplicação clínica de projeto original

“…Therefore, the same pump model can present different degrees of cellular trauma many times related to small changes in the "design", what have demonstrated through studies and evaluation of the pump flow with the same diameter, but with varied positions of the wings in relation to the axis, observing a difference as to the movement of the particles in its interior [14].…”