Development and evaluation of bio-nanoparticles as novel drug carriers for the delivery of Selegiline

Goswami, Laxmi; Madhav, N. V. Satheesh; Upadhyaya, Kumud

doi:10.3329/icpj.v5i4.27018

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…The isolated biopolymers were found to be free flowing with their uniform particle size. The SEM image revealed that the most of the biopolymers were found to be granular in nature with flaky appearance which revealed their polymeric nature of the biopolymers [32]. FTIR analysis of biopolymers revealed their polymeric nature because of the presence of different functional group like alcoholic, carboxylic group, ketonic group, amino group et.…”

Section: Future Aspects Of Biopolymers In Drug Deliverymentioning

confidence: 97%

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Assessment of Mycological Quality of Groundwater in Yenagoa Metropolis, Bayelsa State, Nigeria

Richard¹,

Aseibai²

2021

SJMH

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This study examined the mycological quality of groundwater in Yenagoa metropolis, Bayelsa State, Nigeria. Triplicate water samples were obtained from 8 locations in the metropolis, and the fungi quality analyzed following standard microbiological procedures. Results showed that total fungi density ranged from 5.2±1.00 x102 to 8.50±0.56 x103 CFU/ml. Analysis of variance indicates statistical variation (p=0.001) across locations with total fungi density exceeding the limit of 102 CFU/ml specified by World Health Organization/Food and Agricultural Organization for potable water in 62.50% of samples. Eight fungi isolates (species) were identified in the study with frequency across the locations as follows: Aspergillus flavus (20.59%), Aspergillus fumigatus (20.59%), Aspergillus niger (20.59%), Cladosporum (5.88%), Fusarium (2.94%), Mucor (8.82%), Penicilium (14.71%) and Rhizopus (5.88%). Of these, Aspergillus species were predominant across the locations. Since groundwater meets diverse purposes, it is essential that it is suitable for the desired use, and this can be done using appropriate technology to make groundwater potable for human consumption.

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Section: Future Aspects Of Biopolymers In Drug Deliverymentioning

confidence: 97%

“…Biopolymers [1], isolated from natural sources may be used as novel excipients having a polymeric nature. These isolated biopolymers have excellent bioretardant, bio stabilizer, and mucoadhesive properties.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Mycological Quality of Groundwater in Yenagoa Metropolis, Bayelsa State, Nigeria

Richard¹,

Aseibai²

2021

SJMH

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“…3. Thus economically isolated biopolymer can be safely used for developing the most suitable and stable drug-loaded bio-nanosuspension in drug targeting in a very significant way route with maximum patient compliances [36,38,57,[79][80][81].…”

Section: Formulation Of Drug Loaded Bio-nanoparticulate Systemmentioning

confidence: 99%

Biopolymer: A Novel Bioexcipient

Kumar¹,

N²,

Madhav³

2022

Biocomposites

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Polymers are the key material in design of drug delivery systems. These have been shown as the spine for drug development process. These accept an essential part in rising of novel drug delivery systems to crush different intricacies in drug delivery. These are used for controlling the appearance of the drug in needed manner. The hydrophilic and lipophilic polymers are the most ideal choice for getting the ideal conveyance in controlled, manner at the target sites. Isolated of this, these fabricated and semisynthetic polymers are made by different chemical reactions and purification measures. Since these are prepared by different unit operations which are costly. By and by days different investigates are being examined for avoiding the characteristic, physiological and reasonable issues related with the synthetic and semisynthetic polymers. So an alternative rather than synthetic and semisynthetic polymers are being investigated having interest, probability, and any leftover benefits with least troublesome ramifications for environment and physiology of the people. One of the alternatives as opposed to designed and semisynthetic polymers is biopolymers which have pulled in the thought of researchers by using an economical procedures. Biopolymers are novel, adroit and sharp polymers which have been confined from various basic sources. Biopolymers isolated from natural sources might be utilized as novel excipients having a polymeric nature. These isolated biopolymers have superb bioretardant, bio stabilizer, and mucoadhesive properties. These have the brilliant film-framing capacity and biocompatibility properties. The isolated bio-polymers have great drug release rate controlling capacities. Since these are biodegradable and might be utilized as an option in contrast to standard manufactured synthetic and semisynthetic polymers. The isolated biopolymer shows critical biodegradable, mucoadhesive, filmability, and retardability properties which are like properties of standard polymers, may be the alternative in design of novel drug delivery system design.

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“…Nanoparticles are investigated for several pharmaceutical functions due to their ability to guard drug from protein degradation, management the discharge of medicine, and enhance drug penetration and absorption at the particular membrane sites resulting in exaggerated bioavailability. Conjointly nanoparticle will offers a powerful adhesion attributable to the exaggerated contact space for van der Waals attraction [5][6][7]. Olanzapine, a BCS category II compound poorly soluble, however extremely permeable, exhibiting bioavailability that is restricted by the dissolution rate [8].…”

Section: Introductionmentioning

confidence: 99%

Untitled

Madhav

Singh

2019

Asian J. Nanosci. Mater.

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The aim of the study was to prepare and characterize the nanosize drug loaded bio-flexi films using the novel bioexcipient isolated from the fresh leaves of the piper betle (bioexcipient P) and to explore the potentiality of the lip skin as a novel transvermillion drug delivery system. The bioexcipient prepared using a simplified economical process and was subjected to various physiochemical evaluations along with the spectral analysis including UV, FT-IR, SEM, Mass and 1 H NMR. The nanosized bioflexi film formulated with the novel bioexcipient was screened for its functional properties, such as including filmability. Nanosized olanzapine loaded bioflexi films were formulated by using bioexcipient P as a film former and dextrose as a flexicizer. The formulated nanosized bioflexi films were subjected to various tests such as evaluating the, thickness, folding endurance, swelling index and in vitro release. The size of the nanoparticle was found to be 100 nm. The release of the nanosized olanzapine was maintained over 48 h, which was confirmed in in vitro release experiment. The results revealed that this biopolymer had a promising filmability and bioadhesivity. The formulated nanosized bioflexi films are feasible for delivering the olanzapine by transvermillion administration and for drugs that undergo first-pass metabolism.

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Development and evaluation of bio-nanoparticles as novel drug carriers for the delivery of Selegiline

Cited by 5 publications

References 12 publications

Assessment of Mycological Quality of Groundwater in Yenagoa Metropolis, Bayelsa State, Nigeria

Assessment of Mycological Quality of Groundwater in Yenagoa Metropolis, Bayelsa State, Nigeria

Biopolymer: A Novel Bioexcipient

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