2015
DOI: 10.1089/jop.2014.0152
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Development and Evaluation of Dexamethasone Nanomicelles with Potential for Treating Posterior Uveitis After Topical Application

Abstract: In conclusion, the nanomicelles of P40S and P80 could efficiently solubilize 0.1% dexamethasone in their cores. The results also indicate that mixed nanomicelles could be utilized as a potential delivery system for delivering dexamethasone to treat the back of the eye diseases such as posterior uveitis after topical application.

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Cited by 41 publications
(15 citation statements)
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References 29 publications
(41 reference statements)
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“…[45] In addition to their ability to increased transcorneal penetration, their ability to improve the solubility of lipophilic drugs may play an important role in increasing the intravitreal half-life and thus bioavailability of lipophilic drugs like propranolol and metoprolol. [45] Moreover, like in situ gels, they also increase precorneal drug retention time due to their increased viscosity thereby achieving a sustained release formulation leading to a decrease in administration frequency and reduced drug toxicity. [46] Like liposomes, however, nano-carriers share many of the same limitations associated with micelle-based systems including formulation stability, control of particle size, and control of drug release rate and large-scale manufacture of sterile preparations.…”
Section: Liposomesmentioning
confidence: 99%
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“…[45] In addition to their ability to increased transcorneal penetration, their ability to improve the solubility of lipophilic drugs may play an important role in increasing the intravitreal half-life and thus bioavailability of lipophilic drugs like propranolol and metoprolol. [45] Moreover, like in situ gels, they also increase precorneal drug retention time due to their increased viscosity thereby achieving a sustained release formulation leading to a decrease in administration frequency and reduced drug toxicity. [46] Like liposomes, however, nano-carriers share many of the same limitations associated with micelle-based systems including formulation stability, control of particle size, and control of drug release rate and large-scale manufacture of sterile preparations.…”
Section: Liposomesmentioning
confidence: 99%
“…Nano‐micelle systems are made up of highly stable lipophilic, hydrophilic or amphiphilic molecules and used pharmaceutically to transport drugs to their target site, most often to improve the solubility of the drug . Their primary benefit as a drug carrier for posterior ocular drug delivery is that they are capable of increasing penetration across the conjunctival and corneal epithelium by temporarily altering the tight junctions when administered topically .…”
Section: The Different Types Of Novel Ocular Drug Delivery Systemsmentioning
confidence: 99%
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“…Patel et al (2015) formulated nanomicelles by polyoxyl 40 stearate (P40S) and polysorbate 80 (P80) and developed dexamethasone nanomicelles. The mean diameter of blank and drugloaded nanomicelles was 13.3 ± 0.4 and 14.5 ± 0.4 nm.…”
Section: Nanomicelles In Drug Deliverymentioning
confidence: 99%
“…Formulation sterility was tested using the plate as well as direct/tube inoculation methods. The study was carried out under aseptic conditions, as per our published protocol[126,127]. All the glassware used for the study wasautoclaved and non-autoclavable materials were thoroughly wiped with isopropyl alcohol.…”
mentioning
confidence: 99%