Development and evaluation of gastro-retentive drug delivery systems of cefuroxime axetil

Gudigennavar, S.

doi:10.5897/ajpp12.1211

Cited by 9 publications

(4 citation statements)

References 9 publications

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“…Friability: Tablet friability was evaluated using a Roche's friabilator. About 10 tablets were weighed and put into the friabilator that was rotated at 25 rpm for 4 minutes [16]. The tablets were weighed again and the % friability was calculated.…”

Section: Post-compression Parametersmentioning

confidence: 99%

Enhancing Oral Absorption of Orlistat through Gastroretentive Mucoadhesive Pellets: Formulation and Evaluation

Thummala,

Vallabhareddy,

Sarella

2023

J Cli Pharm Res

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Aim: The aim of this study was to develop gastroretentive mucoadhesive pellets of Orlistat to improve its oral bioavailability and enhance its absorption. Methods: Orlistat pellets were prepared using Hydroxy Propyl Methyl Cellulose (HPMC) K100M, Sodium Carboxy Methyl Cellulose (NaCMC), Carbopol 934P, and Polyvinyl Pyrrollidone (PVP) K30 in varying ratios. Physical characteristics of the tablets were evaluated, and compatibility studies were performed between Orlistat and the excipients. Swelling index, mucoadhesion strength and drug release were measured for each formulation. Drug release kinetics and stability studies were carried out. Results: The combination of HPMC K100M, NaCMC, Carbopol 934P and PVP K30 provided balanced release and mucoadhesion with F13 showing sustained release up to 16 hours. The calibration curve demonstrated a good linear relationship between Orlistat concentration and absorbance over the range of 10 to 50 ?g/ml. Swelling index increased with time and polymer concentration and mucoadhesion strength increased with polymer viscosity and concentration. Drug release from formulations containing HPMC K100M, NaCMC and Carbopol 934P were 12-14 hours, 10-12 hours and 8-11 hours, respectively. Combination polymers in F10-F13 provided balanced release and mucoadhesion, with F13 showing sustained release up to 16 hours. The drug release followed zero order kinetics with non-Fickian diffusion. Stability studies on the optimized F13 formulation showed no significant changes in appearance, hardness, mucoadhesion or drug release over 3 months. Conclusion: The combination of HPMC K100M, NaCMC, Carbopol 934P and PVP K30 improved the oral bioavailability and absorption of Orlistat. The study demonstrated the importance of compatibility studies and the use of calibration curves for quantitative analysis. The findings provide valuable insights into the development of drug delivery systems for poorly bioavailable drugs.

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Section: Post-compression Parametersmentioning

confidence: 99%

Enhancing Oral Absorption of Orlistat through Gastroretentive Mucoadhesive Pellets: Formulation and Evaluation

Thummala,

Vallabhareddy,

Sarella

2023

J Cli Pharm Res

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“…The absorbance was measured at 280 nm using a UV spectrophotometer (Systronic, Ahmedabad, India). The standard calibration curve of Cefuroxime Axetil in 0.1N HCl 8,9 as shown in Fig. 1.…”

Section: Preparation Of Standard Plot Of Cefuroxime Axetilmentioning

confidence: 99%

Formulation in Vitro and in Vivo Evaluation of Cefuroxime Axetil Floating Tablets Using Natural Gums

Swapna¹,

2019

Int J Life Sci Pharm Res

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Floating tablets of Cefuroxime Axetil were prepared using Albizia gum, Dammar gum and Moi gum as polymers for controlling the drug release. Cefuroxime Axetil is a poorly water-soluble drug (second-generation cephalosporin) and its bioavailability is very low. The rate of absorption and the extent of bioavailability for such insoluble drug are controlled by the rate of dissolution in the gastrointestinal fluids. Two types of diluents were used and the drug release was compared. Pure drug and optimized formulation were subjected to the drug excipient compatibility studies using FTIR and DSC. The studies revealed that there was no interaction between the drug and excipients. In order to increase the drug release, channeling agents were introduced namely Lactose and DCP. Lactose is water soluble diluent and DCP is water insoluble diluent. All the formulations were taken and studied for the precompression parameters and found that they were within the limits. Precompression parameters were performed to all the formulations and were found to be in the acceptable limit which ensures the good flow properties. Formulation F4CADL containing gum dammar and lactose as channeling agent showed good results when compared with other formulations. The floating lag time of the optimized formulation was very short and the percentage of drug release at the end of 12 hours was found to be high. The drug release kinetics revealed that F4CADL follows Korsmeyer-Peppas and the mechanism was non-fickian diffusion. Optimized formulation was selected for in vivo studies by using albino rabbits. It was found that the tmax was extended for prolonged period of time.

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“…Gastroretentive dosage form overcomes that demerit by releasing the drug continuously in the upper part of gastrointestinal tract, thereby achieving the better control of plasma glucose level [3][4] . The exhaustive literature research elucidates that gastro retentive formulations of Glimepiride have been prepared using several approaches [5][6][7][8] . Present research involves the development of gastroretentive floating matrix tablets of GLM by effervescence mechanism.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Gastro retentive Glimepiride Floating Matrix Tablets

Kamere

S.V²,

G.V³

2022

Int J Life Sci Pharm Res

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The main objective of this research investigational studies is to formulate floating matrix tablets of glimipride by applying simplex centroid design for optimization technique and by direct compression method. The simplex Centroid configuration was drilled as an enhancement strategy by adjusting the amount of three components all the while and holding back their total concentration constant. Ingredients HPMC K15m, Kappa-carrageenan and sodium bicarbonate as X1,X2,X3 independent Variables while response variables Y1 floating lag time Y1, Percentage drug released after 1 hour Y2% and t90 time required for 90% were considered as response variable factors for formulation and optimization of total 14 formulations simplex centroid design was applied. The measures of HPMC K15M (X1), kappa-Carrageenan (X2) and sodium bicarbonate (X3) were utilized as the autonomous factors while coasting slack time (Y1), Percentage drug discharged after 1 hour(Y2) and time required for 90% (t90) were taken as the reaction factors. According to the simplex centroid configuration complete 14 formulations were formulated. Matrices were evaluated for physical parameters, in-vitro buoyancy, swelling ability and adhesion retention period. It was inferred that the blend of kappa carrageenan and HPMC K 15 M builds the adaptability in the release pattern of the drug. This examination sets up the utilization of simplex centroid structure in the advancement of coasting network tablets with least experimentation.

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Development and evaluation of gastro-retentive drug delivery systems of cefuroxime axetil

Cited by 9 publications

References 9 publications

Enhancing Oral Absorption of Orlistat through Gastroretentive Mucoadhesive Pellets: Formulation and Evaluation

Enhancing Oral Absorption of Orlistat through Gastroretentive Mucoadhesive Pellets: Formulation and Evaluation

Formulation in Vitro and in Vivo Evaluation of Cefuroxime Axetil Floating Tablets Using Natural Gums

Formulation and Optimization of Gastro retentive Glimepiride Floating Matrix Tablets

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