Development and Evaluation of Herbal Supplement: A Quality by Design Approach

Gaonkar, V. M. Parab; Mannur, V.S.; Mastiholimath, Vinayak Shivamurthi; Hullatti, Kirankumar

doi:10.36468/pharmaceutical-sciences.690

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…These combinations represented eight distinct ratios of NS:MC:AG, namely: 110:50:25, 110:50:35, 110:80:25, 110:80:35, 215:50:25, 215:50:35, 215:80:25, and 215:80:35. These experimental trials were meticulously designed using Systat software (version 13.2, USA) to explore the various concentration combinations of the herbal drugs in the formulation [ 18 , 19 ]. Each combination was then assessed and analyzed to establish optimal conditions for the herbal formulation.…”

Section: Methodsmentioning

confidence: 99%

Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses

Chavan,

Khatib,

Hariprasad

et al. 2024

Heliyon

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Section: Methodsmentioning

confidence: 99%

Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses

Chavan,

Khatib,

Hariprasad

et al. 2024

Heliyon

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“…Lastly, oval capsule-shaped tablets with an average weight of 750 mg were compressed using a 10-station single rotary tablet press with 19 mm punches. 28,29…”

Section: Determination Of Pre-compression and Post Compression Parame...mentioning

confidence: 99%

“…The Design-Expert software produced 3-D contour plots. 27,29,30 FTIR study (Fourier Transform Infra-Red)…”

Section: Linear Modelmentioning

confidence: 99%

“…The Table 3 presents the pre-compression values. According to the USP requirement, all the batches met Angle of repose (25)(26)(27)(28)(29)(30) as Excellent, (31-35) Good, Carr's index (12)(13)(14)(15)(16) as Good, (5-15) Excellent, and Hausner's ratio (1.12-1.18) as Good, (1-1.11) Excellent. So, we draw the conclusion that all of the batches had efficient precompression settings.…”

Section: Parametersmentioning

confidence: 99%

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Design, Optimization and Characterization of Newer Herbal Tablet Containing Momordica dioica Extract

Patel,

Chaudhary,

Gandhi

2023

Int J. Pharm. Investigation

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Background: Momordica dioica (MD) is called the teasle gourd, spiny gourd, and kakrol. Among the important phytochemicals present in MD include alkaloids, flavonoids, phenolics, tannins, saponins, steroids, glycosides, and terpenes. These compounds have a high potential to cure many illnesses. Herbal plant extracts exhibit mucilage, high viscosity, and limited flowability qualities. It is challenging to create the herbal formulation because of these characteristics. Herbal medications may be one of the safest options with the fewest adverse effects. Objectives: Formulation and Optimization of a novel herbal tablet containing Momordica dioica extract by applying 3 2 factorial designs for the improvement of hardness and In vitro drug release. Materials and Methods: The tablets were made using Sodium Starch Glycolate (SSG) as a super disintegrant and Polyvinylpyrrolidone-K30 (PVP-K30) as a binder. The study was designed to optimize the formulation, and the model that resulted from that experiment was validated. Design Expert software 11 used a 3-level 2 factorial (3 2 ) design. Several pre-and post-compression characteristics were evaluated to determine the formulation's quality. Results: Formulated tablet batches B1 to B9 were tested for various parameters. It was discovered that the values ranged from 3.2 to 3.6 kg/cm 2 in hardness, 5.9 to 6.2 mm in thickness, 735-765 mg in weight variation, 18 to 27 sec to wet the tablet, 16 to 19 min to disintegrate, 0.25 to 0.51% in friability, and 98 to 101% in drug content. The best drug release and hardness were achieved with PVP K 30 (6%) and SSG (6%). A promising batch was found as batch B5. Conclusion: The findings suggest that PVP-K30 and SSG are the two best excipients when making herbal tablets.

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“…The initial CQA was defined from QTPP to identify the satisfactory quality of the product. The potential CQA of excipients required for the development of herbal hydrogel 11 .…”

Section: Quality Target Product Profile (Qtpp)mentioning

confidence: 99%

Untitled

2023

IJPSR

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The current study was undertaken to formulate and evaluate herbal hydrogel containing ethanolic seed extract of plant Coix lacryma jobi L. Hydrogel was prepared by ethanolic seed extract, carbapol 934p, aloevera gel extract, triethanolamine and methylparaben. The effects of critical parameters (concentration of Carbapol 934p and Aloe vera gel extract) were investigated by executing design of the experiment using 3 2 factorial designs through Design Expert 12 version software. All the formulations were developed and evaluated for visual inspection, pH, viscosity, spreadability, drug release and drug content. Optimized formulation was subjected to invitro antifungal activity against Candida albicans. It was observed that formulation variables X 1 : Carbapol 934p and X 2 : Aloeveragel extract significantly affected the response Y 1 : Viscosity (cp) and Y 2 : Drug release (% Drug release). Stability studies conducted under accelerated conditions and at room temperature were shown acceptable results. It was concluded that hydrogel containing coix ethanolic seed extract showed good consistency, spreadability, homogeneity, and stability. This study confirmed that quality by design is an effective approach for understanding the quality parameters for optimizing Hydrogel formulation.

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Development and Evaluation of Herbal Supplement: A Quality by Design Approach

Cited by 6 publications

References 9 publications

Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses

Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses

Design, Optimization and Characterization of Newer Herbal Tablet Containing Momordica dioica Extract

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