Development and Evaluation of Itraconazole Solid Dispersion Gel Cutaneous Delivery

Abstract

Objective: The objective of this research is to enhance the permeation of low bioavailable drugs with suitable dosage forms by utilizing various permeation enhancers. Methods: Solid dispersions (SDs) were prepared by kneading, whereas physical mixtures (PM) were prepared by simple mixing with polymers PEG 6000 and PEG 20000 and evaluated for various physicochemical parameters. Optimized SDs were converted to gels using a variety of polymers and were evaluated for in vitro and ex vivo permeation studies. Results: It was found that the percentage of drugs in SDs and PMs was within the limit. The dissolution of SDs and PMs was found to be the highest with PEG-6000 (99.78% within 240 min) compared to PEG 20000. The maximum drug release (92.9% within 8 h) was achieved with oleic acid in both in vitro and ex vivo permeation studies, as evidenced by the in vitro and ex vivo permeation studies. The developed formulations showed no incompatibility between drugs and excipients, as demonstrated by drug and excipient interaction studies. Conclusion: The results that were observed confirmed that the itraconazole PEG-6000 gel developed has promising effects on desirable skin permeation.

Enhancing the Physical Characteristics and Shelf Life of Rice Water (Oryza Sativa L.) Gel Shampoo: The Role of Propylene Glycol Concentration

“…HPMC K4M is a gelling agent not affected by electrolytes, can be mixed with preservatives, and has a wide pH range. PG functions as a humectant that binds water from humid air while retaining the water of the preparation [20]. The maximum concentration of PG as a humectant for topical preparations is 15% [21].…”

The Impact of Superficial Dermatophytosis on Quality of Life in a Rural Population: A Cross-Sectional Observational Study

“…It affects their sleep, personal life, work life, as well as social life. There have been many promising studies on advanced treatment options that aim to improve the overall quality of life (QoL) of patients suffering from dermatophytosis [11,12]. In general, QoL is the patient's sense of well-being in various domains of life, such as physical health, psychological status, sexual well-being, financial status, occupation, and social interaction [13].…”