Development and evaluation of mucoadhesive buccal dosage forms of lidocaine hydrochloride by ex-vivo permeation studies

Kottke, D; Majid, Haidara; Breitkreutz, Jörg; Burckhardt, Bjoern B.

doi:10.1016/j.ijpharm.2020.119293

Cited by 22 publications

(4 citation statements)

References 21 publications

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“…Considering special populations, e.g., children, the accidental swallowing of lidocaine has been reported by the US Food and Drug Administration (FDA) to result in seizures, severe brain injuries, heart-related problems, or even death. 50,51 Regarding Keto, the data revealed the complete release of the API within an extended timescale, whereas the incorporation of the backing layer significantly decreased the release rate of Keto. This is a common behavior for the buccal delivery of NSAIDs, as the prolonged delivery of the APIs provides the optimal local anti-inflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

Eleftheriadis

Monou

Bouropoulos

et al. 2020

Journal of Pharmaceutical Sciences

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Section: Discussionmentioning

confidence: 99%

Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

Eleftheriadis

Monou

Bouropoulos

et al. 2020

Journal of Pharmaceutical Sciences

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“…Recently, mebeverine, an antispasmodic, was investigated for its anesthetic potential in the buccal cavity [56]. Lignocaine is the most commonly used topical anesthetic agent delivered through the mucoadhesive buccal route [57][58][59], followed by benzocaine [60,61] and articaine [62]. Lignocaine and benzocaine have been tested in healthy volunteers for the treatment of local oral cavity pain [63].…”

Section: Local Anestheticsmentioning

confidence: 99%

Recent Advances in Nanotechnology Formulations to Treat Diseases of the Oral Cavity

Sindi¹

2023

Preprint

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Advances in nanotechnology have paved the way for more effective drug delivery using particulate and non-particulate nano-based formulations across a range of applications. In the oral cavity, local delivery using mucoadhesive formulations has advantages over conventional formulations for increasing local efficacy whilst reducing unwanted adverse effects. Nano-formulations provide the opportunity for new formulations with enhanced intraoral stability, local action, and improved patient acceptability.

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“…The key objective of pharmacotherapy in disease management involves the effective delivery of the active pharmaceutical ingredients (APIs) to the target site at the desired concentration and rate. Poorly soluble drug candidates continue to pose challenges for their optimal delivery and hence, have drawn the attention of researchers across the world (Hota et al, 2020; Kottke et al, 2020; Pattnaik et al, 2011; Swain et al, 2010; Yadav et al, 2019). Poor aqueous solubility of drug molecules often limits gastrointestinal absorption and hence oral bioavailability leading to therapeutic failure.…”

Section: Introductionmentioning

confidence: 99%

Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions

Pattnaik

Swain

Ramakrishna

2022

WIREs Nanomed Nanobiotechnol

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Poor aqueous solubility of both, existing drug molecules and those which are currently in the developmental stage, have posed a great challenge to pharmaceutical scientists because they often exhibit poor dissolution behavior and subsequent poor and erratic bioavailability. This has triggered extensive research to explore nanotechnology‐based technology platforms for possible rescue. Recently, nanofibers have been exploited widely for diverse biomedical applications including for drug delivery. Electrospun nanofibers are capable of preserving the homogeneously loaded therapeutic agents in amorphous state potentialy impairing devitrification. The present review aims at providing an overview of the various key factors that affect the electrospinning process and characteristics of the nanofibers while fabrication of drug loaded nanofibers for poorly soluble drug candidates. The review explores various methodological advancements in the electrospinning process and set‐ups for production scale‐up. The various types of electrospun nanofibers (like simple matrix, core‐sheath, Janus, and inclusion complex nanofibers) that have been exploited for the delivery of poorly soluble drugs are also critically assessed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Development and evaluation of mucoadhesive buccal dosage forms of lidocaine hydrochloride by ex-vivo permeation studies

Cited by 22 publications

References 21 publications

Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

Recent Advances in Nanotechnology Formulations to Treat Diseases of the Oral Cavity

Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions

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