Development and evaluation of novel biodegradable microspheres based on poly(d,l-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies

Mundargi, Raghavendra C.; Sridharan, Srirangarajan; Agnihotri, Sunil A.; Patil, Sangamesh A.; Ravindra, S.; Setty, Swati; Aminabhavi, Tejraj M.

doi:10.1016/j.jconrel.2007.01.008

Cited by 169 publications

(92 citation statements)

References 37 publications

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“…25,48,49 In most of the nanoparticles prepared in this work (OO5, WOW6, SOW7-9, NP10), we observed linear minocycline release rates after the burst effect for more than 5 days, and this profile could be ideal for periodontal disease. 50 The initial burst could be ascribed to the minocycline distributed at or just beneath the surface of the nanoparticles. The later constant release is mainly due to drug diffusion and matrix erosion mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Dinarvand¹,

Kashi²,

Eskandarion³

et al. 2012

IJN

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Background: Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was to investigate different methods of producing PLGA nanoparticles containing minocycline, a drug suitable for periodontal infections. Methods: Different methods, such as single and double solvent evaporation emulsion, ion pairing, and nanoprecipitation were used to prepare both PLGA and PEGylated PLGA nanoparticles. The resulting nanoparticles were analyzed for their morphology, particle size and size distribution, drug loading and entrapment efficiency, thermal properties, and antibacterial activity. Results: The nanoparticles prepared in this study were spherical, with an average particle size of 85-424 nm. The entrapment efficiency of the nanoparticles prepared using different methods was as follows: solid/oil/water ion pairing (29.9%) . oil/oil (5.5%) . water/oil/water (4.7%) . modified oil/water (4.1%) . nano precipitation (0.8%). Addition of dextran sulfate as an ion pairing agent, acting as an ionic spacer between PEGylated PLGA and minocycline, decreased the water solubility of minocycline, hence increasing the drug entrapment efficiency. Entrapment efficiency was also increased when low molecular weight PLGA and high molecular weight dextran sulfate was used. Drug release studies performed in phosphate buffer at pH 7.4 indicated slow release of minocycline from 3 days to several weeks. On antibacterial analysis, the minimum inhibitory concentration and minimum bactericidal concentration of nanoparticles was at least two times lower than that of the free drug. Conclusion: Novel minocycline-PEGylated PLGA nanoparticles prepared by the ion pairing method had the best drug loading and entrapment efficiency compared with other prepared nanoparticles. They also showed higher in vitro antibacterial activity than the free drug.

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Section: Discussionmentioning

confidence: 99%

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Dinarvand¹,

Kashi²,

Eskandarion³

et al. 2012

IJN

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“…One popular biodegradable polymer class for drug delivery is the polyesters, which include polylactides, poly(e-caprolactone), poly(3-hydroxybutyrate and poly(glycolic acid) [40]. These polymers and various copolymer compositions have shown considerable potential as effective drug carriers [41,42] and have been extensively studied for the controlled release of drugs due to their tunable degradation rates (from months to years), wide range of mechanical properties and biodegradability [40,[43][44][45][46][47][48][49]. Poly(l-lactide) (PLLA) is particularly advantageous since its degradation product, lactic acid, is well tolerated by the body [50][51][52][53].…”

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confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

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Aims: Porous silicon (pSi) and poly(L-lactide) (PLLA) both display good biocompatibility and tunable degradation behavior, suggesting that composites of both materials are suitable candidates as biomaterials for localized drug delivery into the human body. The combination of a pliable and soft polymeric material with a hard inorganic porous material of high drug loading capacity may engender improved control over degradation and drug release profiles and be beneficial for the preparation of advanced drug delivery devices and biodegradable implants or scaffolds. Materials & methods: In this work, three different pSi and PLLA composite formats were prepared. The first format involved grafting PLLA from pSi films via surface-initiated ring-opening polymerization (pSi–PLLA [grafted]). The second format involved spin coating a PLLA solution onto oxidized pSi films (pSi–PLLA [spin-coated]) and the third format consisted of a melt-cast PLLA monolith containing dispersed pSi microparticles (pSi–PLLA [monoliths]). The surface characterization of these composites was performed via infrared spectroscopy, scanning electron microscopy, atomic force microscopy and water contact angle measurements. The composite materials were loaded with a model cytotoxic drug, camptothecin (CPT). Drug release from the composites was monitored via fluorimetry and the release profiles of CPT showed distinct characteristics for each of the composites studied. Results: In some cases, controlled CPT release was observed for more than 5 days. The PLLA spin coat on pSi and the PLLA monolith containing pSi microparticles both released a CPT payload in accordance with the Higuchi and Ritger–Peppas release models. Composite materials were also brought into contact with human lens epithelial cells to determine the extent of cytotoxicity. Conclusion: We observed that all the CPT containing materials were highly efficient at releasing bioactive CPT, based on the cytotoxicity data. Original submitted 16 December 2010; Revised submitted 29 September 2011; Published online 6 March 2012

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“…Periodontology can also profit from the controlled delivery proprieties of PLGA microparticles. In fact, tetracycline [152], doxycycline [153], and chlorhexidine [154] are effectively released locally for periodontal treatment and regeneration. Similarly, PLGA microspheres incorporated with HA and ofloxacin showed good results against S. aureus and E. coli [155], while PDLLA-PLGA microparticles filled with growth and differentiation factors accelerate osteogenesis, bone maturation, fibers realignment, and cementogenesis of the periodontal apparatus in rats maxillae [156].…”

Section: Polyestersmentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Development and evaluation of novel biodegradable microspheres based on poly(d,l-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies

Cited by 169 publications

References 37 publications

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

Biodegradable polymers for dental tissue engineering and regeneration

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