Development and evaluation of oral controlled release tablets of oxybutynin using various polymers

Ravi, G.; Bose, P. Subhash Chandra; Ravi, Valluru; Sarita, Damineni; Reddy, P. Srikanth; Kanna, Sandeep

doi:10.5958/0974-360x.2020.00682.4

Cited by 3 publications

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“…A definite time interval was withdrawn 5 ml of sample, filtered, and again 5 ml media was replaced. Suitable dilutions were done with media and analyzed by spectrophotometrically at respective wavelengths using UVspectrophotometer [28].…”

Section: In Vitro Drug Release Of Zafirlukast Core Tabletsmentioning

confidence: 99%

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

Krishna¹,

Jayanthi²,

Madhukar³

2021

Int J App Pharm

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Objective: The main objective of the present study was to formulate and evaluate a time-controlled single-unit oral pulsatile drug delivery system containing Zafirlukast for the prevention of nocturnal asthma attacks. To provide time-scheduled drug release for Asthma disease. It is used for preventing asthmatic attacks at early morning. Pulsatile release dosage form is increasing patient compliance by reducing the dosing frequency, especially in the early morning. Methods: Core tablets were prepared by incorporating different concentrations of natural and synthetic super disintegrants. Drug-containing core tablets (ZC1-ZC15) with different compositions of natural super disintegrants (Plantago ovata seed powder, Locust bean gum) synthetic super disintegrants (Sodium starch glycolate (SSG), Cross carmellose sodium (CCS), Crospovidone (CP)) were prepared by direct compression technique. The core tablets were subjected to pre-formulation, physicochemical and In vitro drug release studies. The fast disintegrating core tablet formulation was selected and press-coated tablets (P1-P11) were prepared with different compositions of hydrophobic polymers Eudragit RS100, Eudragit RL 100, Ethylcellulose and hydrophilic polymers Hydroxypropyl methylcellulose K4M, K100M. The optimized formulation was selected and quantified based on in vitro drug release profile in simulated gastric and intestinal fluids. Results: The pre and post-compression parameters of tablets were also found to be within limits. Formulation ZC5 with 16 mg of Locust bean gum showed the least disintegrating time, i.e., 22.13 sec, and was selected as the best immediate release core tablet. The press-coated tablet formulation P8 having 62.5 mg Eudragit RS100 and 62.5 mg of HPMC K4M in ratio 1:1 over the core tablet ZC5 showed rapid and drug release nearly after 4 h lag time and 98.86 % up to 12 h. Accelerated stability studies of the optimized formulation P8 indicated no significant difference in release profile after 3 mo. Conclusion: The in vitro dissolution study showed that lag time before drug release was highly affected by the coating amount level and nature of coating polymer used. Time-controlled pulsatile release tablets can be prepared using press-coating techniques.

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Section: In Vitro Drug Release Of Zafirlukast Core Tabletsmentioning

confidence: 99%

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

Krishna¹,

Jayanthi²,

Madhukar³

2021

Int J App Pharm

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“…Fourier Transform Infrared (FTIR) spectroscopy 18 The compatibility between the pure drug and excipients was detected by FTIR spectra obtained on Bruker FTIR.The solid powder sample directly place on yellow crystal which was made up of ZnSe. The spectra were recorded over the wave number of 4000 cm -1 to 400 cm -1 .…”

Section: Mechanical Properties 16mentioning

confidence: 99%

Formulation and Evaluation of Clopidogrel Bisulfate Transdermal Patches

Reddy

Alagarsamy

Ravi

et al. 2021

IJMBS

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Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. The main objective of the present work was to develop a suitable matrix type transdermal drug delivery system of Clopidogrel bisulphate using different polymers HPMC E15, Eudragit L100 and to compare the drug release through physical method and chemical method. Matrix type transdermal patches containing Clopidogrel Bisulfate were prepared by solvent evaporation technique. The prepared transdermal patches were evaluated for Thickness, folding endurance, tensile strength and in vitro studies. The prepared transdermal drug delivery system of Clopidogrel bisulphate using different polymers such as HPMC E15 and Eudragit L 100 had shown good promising results for all the evaluated parameters. Based on the In-vitro drug release, drug content and folding endurance results formulation F4 was concluded as an optimized formulation which shows its higher percentage of drug release. Keywords: Transdermal drug delivery, Clopidogrel bisulphate, HPMC E15, Eudragit L100

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Preparation, Evaluation and Development Celecoxib Prolonged Release (PR) Tablets by using Cellulose Polyacrylic acid – based polymers

Suslina

Alkhodri²

2022

RJPT

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Development and evaluation of oral controlled release tablets of oxybutynin using various polymers

Cited by 3 publications

References 0 publications

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

Formulation and Evaluation of Clopidogrel Bisulfate Transdermal Patches

Preparation, Evaluation and Development Celecoxib Prolonged Release (PR) Tablets by using Cellulose Polyacrylic acid – based polymers

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