Development and evaluation of topical emulgel of aspirin using different polymeric bases

Khan, Jiyauddin; Norfarhani, Siti; Sahu, Ram Kumar; Ruhi, Sakina; Kaleemullah, Mohammed; Al-Dhalli, Samer; Rasny, Mohamed; Budiasih, Sri; Baber, Shariq; Ng, Chean Hui; Shamiha, Nik Nur; Khan, Gulam Muhammad; Gamal, O E; Fattepur, Santosh; Nilugal, Kiran Chanabasappa; Abdullah, Ibrahim; Asmani, Fadli; Yusuf, Eddy

doi:10.5958/0974-360x.2020.01096.3

Cited by 21 publications

(5 citation statements)

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“…Khan et al exploited emulgel with aspirin for topical application [ 57 ]; this concept could be further applied in our study. We propose that C. militaris mycelia can be loaded in micro/nanobeads for controlled drug release applications.…”

Section: Discussionmentioning

confidence: 99%

Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris

Yang

Kuo

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Chronic kidney disease (CKD) is a critical public health issue with a huge financial burden for both patients and society worldwide. Unfortunately, there are currently no efficacious therapies to prevent or delay the progression of end-stage renal disease (ESRD). Traditional Chinese medicine practices have shown that Cordyceps militaris (C. militaris) mycelia have a variety of pharmacologically useful properties, including antitumor, immunomodulation, and hepatoprotection. However, the effect of mycelial C. militaris on CKD remains unclear. Methods. Here, we investigated the effects of C. militaris mycelia on mice with CKD using four types of media: HKS, HKS with vitamin A (HKS + A), CM, and CM with vitamin A (CM + A). Results. The results at day 10 revealed that the levels of blood urea nitrogen (BUN) were significantly lower in the HKS (41%), HKS + A (41%), and CM + A (34%) groups compared with those in the corresponding control groups (nephrectomic mice). The level of serum creatinine in the HKS + A group decreased by 35% at day 10, whereas the levels in the HKS and CM + A groups decreased only by 14% and 13%, respectively, on day 30. Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effect on BUN, serum creatinine, body weight, total protein, and uric acid. Conclusions. Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effects on BUN, serum creatinine, body weight, total protein, and uric acid. We concluded that treatment with C. militaris mycelia cultured in HKS or CM + A medium could potentially prevent the deterioration of kidney function in mice with CKD.

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Section: Discussionmentioning

confidence: 99%

Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris

Yang

Kuo

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…If value is equal to 1 then it indicates that all the particles in the suspension are in the equal size range. For identification of PDI, sample was placed in Malvern zetasizer using quartz cuvette and allowed to scan the sample for measuring the particle size distribution [18].…”

Section: Pdi (Poly Dispersity Index)mentioning

confidence: 99%

Design, Development and Improvement of an Emulgel Containing Silver Nanoparticles and Vitamin D-3 for Its Potential to Accelerate the Healing of Wound

YADAV,

PANDEY,

KUKKAR

2024

Int J App Pharm

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Objective: The aim of this research work was to prepare a topical emulgel based dosage form incorporated with vitamin D-3 and silver nanoparticles to reduce the wound healing time in any kind of wound. Methods: Central Composite Design (CCD) was applied for the optimization of emulgel by using Design expert software. Three responses (pH, viscosity, and in vitro drug release) and two factors (Carbopol concentration and stirring duration) were chosen, and Statistical Analysis of Variance (ANOVA) revealed that all the factors were significantly affecting the responses. Silver Nanoparticles (SNPs) was prepared with Green Tea Extract (GTE) and evaluated for particle size, Poly Dispersity Index (PDI), zeta potential and Fourier Transform Infra-red (FTIR) spectroscopy and revealed that SNPs of desired range and stability have been synthesized. Here excision wound model was used to evaluate the wound healing activity of formulation in vivo. Results: Maximum in vitro release 88.2±2.1 has shown by the optimized formulation F13, pH and viscosity were also found in optimum range i.e., 6.2±0.4 and 1672±33 respectively, followed by Korsmeyer and Peppas model. Total eight groups were designed for animal study and silver sulphadiazine was used as marketed formulation. F13 formulation was further evaluated for in vivo data, it was revealed that emulgel loaded with high dose of vitamin D-3 along with silver nanoparticles has shown 100.5±1.7% wound contraction, while marketed formulation has shown 103.7±1.1% wound contraction, which was much similar with test formulation. Cytotoxic cell study was done using assay on chicken egg, formulation has not shown any cytotoxic behaviour like haemolysis and cell damage on chick embryo’s blood vessels. Accelerated stability study of the optimized formulation was also performed to check whether the formulation was stable or not and it was revealed that optimized formulation was found stable for the period of six months. Conclusion: It was revealed that emulgel loaded with high dose of vitamin D-3 and SNPs found suitable to accelerate wound healing and showed almost similar response in wound contraction on comparison with marketed formulation. This emulgel promised to controlled the delivery of the drug for the longer duration.

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“…Stability studies for F6 and F8 were performed for three months, at room temperature (30 ± 20ºC) and at 40ºC. Stability studies were carried out as per ICH guidelines [13,14].…”

Section: Stability Studiesmentioning

confidence: 99%

“…Stability studies were carried out for the drug content, viscosity and pH of the formulations. The result of the particular evaluation is tabulated in the below Table 6 [13,14].…”

Section: Stability Studiesmentioning

confidence: 99%

Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

Kumar

2023

Int J Pharm Sci

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Floating Drug Delivery Systems have been used to overcome some of the problems like low oral absorption of drugs with narrow absorption window as it has an advantage of sustained release of drugs over a prolonged period of time. In-situ gels are the novel approach in the context of floating drug delivery systems. The aim of this present study was to develop an oral stomach specific floating in-situ gel of Azithromycin dihydrate. In-situ gelling system was prepared by dissolving different concentrations of polymers like sodium alginate, xanthan gum in the de-ionized water already prepared with sodium citrate at 60°C to 90°C. After the heating with continuous stirring the formulation was cooled below the temperature of 40°C with the addition of certain amount of drug and calcium carbonate which acts as gas generating agent. All the formulations showed pH in the range of 6.1 to 6.7, drug content was found to be in the range of 97.29% to 99.27%. Floating lag time was less than 1 minute for all the formulations and the duration of floatation was more than 24 hours for the combination of polymers. Appearance and measurement of water uptake by the gel was also good. Stability studies were also done and was found to be at normal phase at different temperatures and at interval of times. Although, F9 showed the maximum properties of an in-situ gel with increased gastric retention time with low slowly release of the drug. Drug release was found to be decreasing as the concentration of polymer increases. However, it was concluded that the in-situ gelling system of Azithromycin dihydrate could be prepared in various concentrations of different polymers and the combination of polymers to increase the patient compliance and reduction in the frequency of dosing of the drug with the increased gastric residence time for the drug in the stomach.

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Development and evaluation of topical emulgel of aspirin using different polymeric bases

Cited by 21 publications

References 0 publications

Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris

Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris

Design, Development and Improvement of an Emulgel Containing Silver Nanoparticles and Vitamin D-3 for Its Potential to Accelerate the Healing of Wound

Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

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