DEVELOPMENT AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM OF PROPRANOLOL HCl

Abstract

Administration of conventional tablets of Propranolol has been reported to exhibit fluctuations in the plasma drug levels, resulting either in manifestation of side effects such as diarrhea, ischemic colitis and mesenteric arterial thrombosis or reduction in drug concentration at the receptor site. Transdermal drug delivery (TDD) method has been selected as it provides controlled release of the drug, and produces a steady blood-level profile, leading to reduced systemic side effects and, sometimes, improved efficacy over other dosage forms. In the present work, efforts have been made to prepare transdermal drug delivery system of Propranolol using various blends of polymers such as Eudragit RS 100, Hydroxy propyl methyl cellulose K100M and Poly vinyl pyrrolidone using propylene glycol as a permeation enhancer. The prepared patches were evaluated for various physicochemical properties and in-vitro drug release studies. The drug release data was fitted to statistical approach such as Zero order kinetics, Higuchi's and Peppa's plot. The optimized formulation from the in-vitro drug release study is used to carry out in-vitro skin permeation study using porcine ear skin, snake shed skin and rat skin. The in-vivo evaluation of formulation F 7 (1.5 % Eudragit RS 100, 1.5 % HPMC K100M) shown better correlation with the in-vitro drug release which confirms the achievement of targets of the present study such as controlled prolonged zero order release, reduced frequency of administration, greater therapeutic effect, overcome the side effects, simplify the treatment regimen and thus may improve patient compliance.

Pharmacological activities of anti-hypertensive drug delivery through a transdermal patch – a brief review

“…Murthy et al [35] To assess how the solvent affected the mechanical and permeability characteristics of the films, rate-controlling membranes for TDDS were created using cellulose acetate and EC with a variety of solvents. A variety of solvents were used to make cellulose acetate and ethyl cellulose films, including acetone: methanol (8:2), dichloro methane: methanol (8:2), chloroform: methanol (8:2), and ethyl acetate: methanol (8:2).…”

Controlled release systems based on polyacrylates and polyacrylates/clay nanocomposites of atenolol drug

“…There for, the development of transdermal drug delivery of the anti‐hypertensive maintaining proper blood level for a long time without adverse effects of frequent oral administration is very important. [ 5−7 ] The use of a release controlling system is a one method to regulate the drug release.…”