The results of the gas-dynamic calculation of the low-pressure cylinder flow part of the K-220-44 type steam turbine intended for operation at nuclear power plants are presented. The ways of the flow part improvement were determined. Some of those ways include the use of innovative approaches that were not previously used in steam turbines. The design of the new flow part was carried out on the basis of a comprehensive methodology implemented in the IPMFlow software package. The methodology includes gas-dynamic calculations of various levels of complexity, as well as methods for analytical construction of the spatial shape of the blade tracts based on a limited number of parameterized values. The real thermodynamic properties of water and steam were taken into account in 3D calculations of turbulent flows. At the final step, end-to-end 3D calculations of the lowpressure cylinder that consists of 5 stages were performed. The technology of parallel computing was applied in those calculations. It is shown that due to the application of innovative solutions, a significant increase in efficiency can be achieved in the developed low-pressure cylinder.