Development and Featuring of the Zeolitic Active Principle FZ: A Glucose Adsorbent

Concepción-Rosabal, Beatriz; Rodrı́guez-Fuentes, G.; Simón-Carballo, R

doi:10.1016/s0144-2449(97)00022-5

Cited by 29 publications

(8 citation statements)

References 3 publications

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“…Animal studies have demonstrated that natural zeolite-clinoptilolite exerts immunostimulatory effects, modulates anti- and pro-inflammatory mechanisms, and postulate its use as an adjuvant in anticancer therapy [ 7 , 8 ]. Other researchers describe zeolite’s capability to adsorb glucose, antidiarrheic effects, and its strong antioxidant activity [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects

Lamprecht

Bogner

Steinbauer³

et al. 2015

Journal of the International Society of Sports Nutrition

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BackgroundZeolites are crystalline compounds with microporous structures of Si-tetrahedrons. In the gut, these silicates could act as adsorbents, ion-exchangers, catalysts, detergents or anti-diarrheic agents. This study evaluated whether zeolite supplementation affects biomarkers of intestinal wall permeability and parameters of oxidation and inflammation in aerobically trained individuals, and whether it could improve their performance.MethodsIn a randomized, double-blinded, placebo controlled trial, 52 endurance trained men and women, similar in body fat, non-smokers, 20–50 years, received 1.85 g of zeolite per day for 12 weeks. Stool samples for determination of intestinal wall integrity biomarkers were collected. From blood, markers of redox biology, inflammation, and DNA damage were determined at the beginning and the end of the study. In addition, VO2max and maximum performance were evaluated at baseline and after 12 weeks of treatment. For statistical analyses a 2-factor ANOVA was used.ResultsAt baseline both groups showed slightly increased stool zonulin concentrations above normal. After 12 weeks with zeolite zonulin was significantly (p < 0.05) decreased in the supplemented group. IL-10 increased tendentially (p < 0.1) in the zeolite group. There were no significant changes observed in the other measured parameters.ConclusionsTwelve weeks of zeolite supplementation exerted beneficial effects on intestinal wall integrity as indicated via decreased concentrations of the tight junction modulator zonulin. This was accompanied by mild anti-inflammatory effects in this cohort of aerobically trained subjects. Further research is needed to explore mechanistic explanations for the observations in this study.

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Section: Introductionmentioning

confidence: 99%

Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects

Lamprecht

Bogner

Steinbauer³

et al. 2015

Journal of the International Society of Sports Nutrition

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“…Furthermore, Zeolites well defined structures and catalytic effects make them an attractive model system for protein and enzyme mimetics [ 46 ]. They are also very effective as glucose adsorbent [ 47 ], antidiarrheal material [ 48 ], gastric antacid [ 49 ], and hypocholesterolemic [ 50 ]. Many accumulating evidences indicate their importance in regulating the immune system, as they act as nonspecific immune-stimulators similarly to superantigens [ 51 , 52 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form

Youssef

Hegazy

Abo-Almaged

et al. 2015

Bioinorganic Chemistry and Applications

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The core-shell method is used as a novel synthetic process of micronized Ti-Zeolite Na-A which involves calcination at 700°C of coated Egyptian Kaolin with titanium tetrachloride in acidic medium as the first step. The produced Ti-coated metakaolinite is subjected to microwave irradiation at low temperature of 80°C for 2 h. The prepared micronized Ti-containing Zeolites-A (Ti-Z-A) is characterized by FTIR, XRF, XRD, SEM, and EDS elemental analysis. Ag-exchanged form of Ti-Z-Ag is also prepared and characterized. The Wt% of silver exchanged onto the Ti-Zeolite structure was determined by atomic absorption spectra. The in vitro cytotoxic activity of Ti-Z-Ag against human hepatocellular carcinoma cell line (HePG2), colon cell line carcinoma (HCT116), lung carcinoma cell line (A549), and human Caucasian breast adenocarcinoma (MCF7) is reported. The results were promising and revealed that the exchanged Ag form of micronized Ti-Zeolite-A can be used as novel antitumor drug.

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“…Clinoptilolite-rich natural zeolites have been applied for drug delivery purposes Rivera et al, 1998Rivera et al, , 2003Concepción-Rosabal et al, 1997Lam et al, 1998;Carballo et al, 2001;Farías et al, 2003;Rivera and Farías, 2005) and as a potential adjuvant in anticancer treatment (Seidel et al, 1997;Parlat et al, 1999;Pavelic et al, 2001Pavelic et al, , 2002. Recently, the clinoptilolite-rich natural zeolite from Western Anatolia and its acid-modified and ionexchanged forms were investigated for its thermal stability, antibacterial activity, water vapor, carbon dioxide and carbon monoxide adsorption and diffusion properties (Top, 2001;Top and Ülkü, 2004;Ülkü, 2004, 2008;Narin, 2001;Narin et al, 2004;Ülkü, 2007, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and bactericidal activity of nitric oxide-releasing natural zeolite

Narin

Albayrak

Ülkü

2010

Applied Clay Science

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The zeolitic tuff from Gördes (Western Anatolia) was used as adsorbent for nitric oxide (NO) storage and release purposes. The NO loading of the zeolite was performed under 20 mL min − 1 NO flow at 30°C and then the zeolite was purged with inert gas in order to remove the species that were reversibly adsorbed and in the gas phase (desorption). The total and reversible adsorption capacities of the zeolite were determined from the adsorption and desorption breakthrough curves, respectively. The NO-loaded zeolite exhibited antibacterial and bactericidal activities against Gram-negative (Escherichia coli) and Gram-positive bacteria (Bacillus subtilis) under physiological conditions. From the NO release kinetics, the diffusion coefficient of NO in the zeolite particle was determined.

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Development and Featuring of the Zeolitic Active Principle FZ: A Glucose Adsorbent

Cited by 29 publications

References 3 publications

Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects

Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects

Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form

Antibacterial and bactericidal activity of nitric oxide-releasing natural zeolite

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