Development and<i>In-Vitro</i>Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

Sarfraz, Rai Muhammad; Akram, Muhammad; Ali, Muhammad; Mahmood, Asif; Khan, Muhammad Usman; Ahmad, H; Qaisar, Muhammad

doi:10.1155/2019/6090965

Cited by 15 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different comonomers give different hydrophobicity to the hydrogels, causing different pHsensitive behaviors. Examples of these are hydrogels based on poly (lactic acid), methoxyl poly (ethylene glycol), and itaconic acid prepared by Ke Wang; pH-responsive co-polymeric hydrogels studied by Umaira Rehman; and polyacrylamide grafted pectin pH-sensitive hydrogel reported by Prashant B. Sutar (Omidia et al, 2019;Sarfraz et al, 2019;Rehman et al, 2021).…”

Section: Ph-sensitive Hydrogelsmentioning

confidence: 99%

Polymeric nanoparticles—Promising carriers for cancer therapy

Xiao

Teng

Shi

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Polymeric nanoparticles (NPs) play an important role in controlled cancer drug delivery. Anticancer drugs can be conjugated or encapsulated by polymeric nanocarriers, which are known as polymeric nanomedicine. Polymeric nanomedicine has shown its potential in providing sustained release of drugs with reduced cytotoxicity and modified tumor retention, but until now, few delivery systems loading drugs have been able to meet clinical demands, so more efforts are needed. This research reviews the current state of the cancer drug-loading system by exhibiting a series of published articles that highlight the novelty and functions from a variety of different architectures including micelles, liposomes, dendrimers, polymersomes, hydrogels, and metal–organic frameworks. These may contribute to the development of useful polymeric NPs to achieve different therapeutic purposes.

show abstract

Section: Ph-sensitive Hydrogelsmentioning

confidence: 99%

Polymeric nanoparticles—Promising carriers for cancer therapy

Xiao

Teng

Shi

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…By using the UV/vis spectrophotometer, the drug released was calculated by determining the absorbance at 233 nm. The same procedure was performed for every formulation to study the in vitro drug release [21].…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Development of Statistically Optimized Chemically Cross-Linked Hydrogel for the Sustained-Release Delivery of Favipiravir

et al. 2022

View full text Add to dashboard Cite

Nowadays, the use of statistical approaches, i.e., Box–Bhenken designs, are becoming very effective for developing and optimizing pharmaceutical drug formulations. In the current work, a Box–Bhenken design was employed using Design Expert version 11 to develop, evaluate, and optimize a hydrogel-based formulation for sustained release of an antiviral drug, i.e., favipiravir. The hydrogels were prepared using the free radical polymerization technique. β-Cyclodextrin (β-CD), N,N′-methylenebisacrylamide (MBA), acrylic acid (AA), and potassium per sulfate (KPS) were used as oligomer, crosslinker, monomer, and initiator, respectively. Three variables, including β-CD (X1), MBA (X2), and AA (X3) were used at various concentrations for the preparation of hydrogels, followed by evaluation of a sol–gel fraction, swelling, porosity, chemical compatibilities, in vitro drug release, and entrapment efficiency. The results of the studies revealed that the degree of swelling was pH dependent, the best swelling being at pH 7.2 (1976%). On the other hand, for the low sol fraction of 0.2%, the reasonable porosity made the hydrogel capable of loading 99% favipiravir, despite its hydrophobic nature. The maximum entrapment efficiency (99%) was observed in optimized hydrogel formulation (F15). Similarly, in vitro drug release studies showed that the prepared hydrogels exhibited a good, sustained release effect till the 24th hour. The kinetic modelling of drug release data revealed that the Korsmeyer–Peppas model was best fit model, describing a diffusion type of drug release from the prepared hydrogels. Conclusively, the outcomes predict that the hydrogel-based system could be a good choice for developing a sustained-release, once-daily dosage form of favipiravir for improved patient compliance.

show abstract

“…The method involved grafting methacrylic acid onto PEG-6000 using methylene bis-acrylamide as a cross-linker. PEG-6000 was chosen based on a critical literature survey, and the copolymeric nanogels were characterized using swelling and release studies . The PEG base hydrogel has tunable structural attributes including cross-linked density, which aids in controlled drug diffusion.…”

Section: Introductionmentioning

confidence: 99%

“…PEG-6000, a nontoxic and water-soluble biomaterial, finds various applications in wound healing, drug delivery, and biomedical fields . Earlier research has demonstrated that PEG-6000-based targeted drug delivery systems can effectively deliver peptides and proteins in a controlled manner . The release of drugs from such systems is influenced by the preparation method, molecular weight, and drug solubility .…”

Section: Introductionmentioning

confidence: 99%

“…The release of drugs from such systems is influenced by the preparation method, molecular weight, and drug solubility . The incorporation of methacrylic acid (MAA) in the nanogel provides pH-responsive properties, as the carboxylic acid groups ionize into carboxylate ions in the basic environment of the gastrointestinal tract, affecting the swelling of the network .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation, In Vitro Characterization, and Evaluation of Polymeric pH-Responsive Hydrogels for Controlled Drug Release

Mahmood,

Sarfraz,

Mahmood

et al. 2024

ACS Omega

Self Cite

View full text Add to dashboard Cite

The purpose of the current research is to formulate a smart drug delivery system for solubility enhancement and sustained release of hydrophobic drugs. Drug solubility-related challenges constitute a significant concern for formulation scientists. To address this issue, a recent study focused on developing PEG-g-poly(MAA) copolymeric nanogels to enhance the solubility of olmesartan, a poorly soluble drug. The researchers employed a free radical polymerization technique to formulate these nanogels. Nine formulations were formulated. The newly formulated nanogels underwent comprehensive tests, including physicochemical assessments, dissolution studies, solubility evaluations, toxicity investigations, and stability examinations. Fourier transform infrared (FTIR) investigations confirmed the successful encapsulation of olmesartan within the nanogels, while thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) studies verified their thermal stability. Scanning electron microscopy (SEM) images revealed the presence of pores on the surface of the nanogels, facilitating water penetration and promoting rapid drug release. Moreover, powder X-ray diffraction (PXRD) studies indicated that the prepared nanogels exhibited an amorphous structure. The nanogel carrier system led to a significant enhancement in olmesartan's solubility, achieving a remarkable 12.3-fold increase at pH 1.2 and 13.29-fold rise in phosphate buffer of pH 6.8 (NGP3). Significant swelling was observed at pH 6.8 compared to pH 1.2. Moreover, the formulated nexus is nontoxic and biocompatible and depicts considerable potential for delivery of drugs and protein as well as heat-sensitive active moieties.

show abstract

Development andIn-VitroEvaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

Cited by 15 publications

References 48 publications

Polymeric nanoparticles—Promising carriers for cancer therapy

Polymeric nanoparticles—Promising carriers for cancer therapy

Development of Statistically Optimized Chemically Cross-Linked Hydrogel for the Sustained-Release Delivery of Favipiravir

Preparation, In Vitro Characterization, and Evaluation of Polymeric pH-Responsive Hydrogels for Controlled Drug Release

Contact Info

Product

Resources

About