Development and in-vitro evaluation of Furosemide Solid Dispersion using different Water Soluble Carriers

Soni, Lokesh; Ansari, M Asad; Thakre, Nisha; Singh, Anjita; Bhowmick, Mithun; Rathi, Jagdish

doi:10.21276/ijrdpl.2278-0238.2017.6(2).2571-2575

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…Our findings in this study are in agreement with the study results of Meenakshi and Khan; they found that solid dispersions of FUR with PVP-K30 prepared by solvent evaporation method in 1:4 drug: carrier ratio enhanced the solubility to a greater extent compared with pure FUR [25]. Soni et al evaluated the aqueous solubility of FUR solid dispersions prepared by the solvent evaporation method with PEG and PVP-K30, solid dispersions with PVP-K30 in 1:2 ratio showed a 4.5-fold increase in aqueous solubility of FUR compared with pure FUR [12]. Solubility study of FUR solid dispersions with PEG and PVP-K30 prepared by fusion and solvent evaporation method indicated that increasing the concentration of the carrier will enhance the aqueous solubility of the poorly soluble drug; this finding is reported by Patel et al, they found that the solubility of FUR-PVP K30 solid dispersions in a ratio of 1:10 was enhanced by 23-fold compared with poorly soluble FUR [21].…”

Section: Discussionmentioning

confidence: 99%

“…The solid dispersions formed were further dried in an oven (Nuve, Turkey) at 40° for 24 h. All the resulting solid dispersions were scraped, pulverized in a mortar and sieved through a 60-mesh sieve. Following that, all solid dispersions were stored in amber glass bottles and kept in the desiccator until further use [12].…”

Section: Solvent Evaporation Methodsmentioning

confidence: 99%

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Formulation and Evaluation of Solid Dispersion Tablets of Furosemide Using Polyvinylpyrrolidone K-30

Elmubarak

Osman

Abdelrahman

2021

Int J Curr Pharm Sci

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Objective: The objective of the present study was to improve the aqueous solubility and dissolution characteristics of the loop diuretic furosemide (FUR); a class IV drug in the Biopharmaceutical Classification System (BCS) using solid dispersion technique. Methods: Solvent evaporation and kneading methods were used to produce solid dispersions of FUR in different ratios with the hydrophilic carrier polyvinylpyrrolidone K-30 (PVP-K30). The prepared solid dispersions were evaluated in terms of solubility study, percentage yield, drug content and Fourier transform infrared spectroscopic study (FT-IR). Tablets containing the optimized formula of solid dispersions ( were formulated and their dissolution characteristics were compared with commercial furosemide tablets. Results: The prepared solid dispersions showed an increase in aqueous solubility, especially those formulated in a 1:2 drug: carrier ratio using solvent evaporation method ( it showed a four-fold increase in solubility compared to the parent drug. The absence of drug-carrier chemical interactions that could affect the dissolution was proved by FT-IR. Solid dispersion tablets exhibited a better dissolution profile in simulated gastric fluid pH 1.2 at 37°C ± 0.5 than the commercial FUR tablets in terms of mean dissolution time (8.44 min) and dissolution efficiency in 30 min (42.54%). Both FUR solid dispersions and commercial tablets followed Weibull and Krosmeyer models as the two best models of drug release kinetics proving that they were immediate release. Conclusion: According to the results obtained in this study, solid dispersion techniques could be successfully used for the enhancement of aqueous solubility and dissolution rate of FUR.

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Section: Discussionmentioning

confidence: 99%

Section: Solvent Evaporation Methodsmentioning

confidence: 99%

Formulation and Evaluation of Solid Dispersion Tablets of Furosemide Using Polyvinylpyrrolidone K-30

Elmubarak

Osman

Abdelrahman

2021

Int J Curr Pharm Sci

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“…The other factor that plays a major role in solubility enhancement is the nanosize, porous, and amorphous structure of GP in GPNs formulations; that give a large surface area available for dissolution in addition to the high internal energy of the amorphous state compared to the crystalline state that led to a faster dissolution rate. The reverse relationship between the dissolution rate and the particle size was verified by many studies, which deliberated the relation between the particle size and the solubility of poorly soluble drugs (Soni et al., 2017 ; Cai et al., 2018 ). At the same time, the greater wettability increased the dissolution rate of the SFCL nanosized powder (Chaudhari et al., 2012 ).…”

Section: Resultsmentioning

confidence: 95%

Synthesized nano particles of glimepiride via spray freezing into cryogenic liquid: characterization, antidiabetic activity, and bioavailability

Gaber

Alhuwaymili²,

Alhawas

et al. 2022

Drug Delivery

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The aim of this work was to formulate glimepiride (class II drug) which is characterized by low solubility and high permeability as nanostructured particles using a cryogenic technique with an aid of water-soluble polymer to improve its aqueous solubility and hence its bioavailability. 27 formula of glimepiride nano size particles were prepared by a spray freezing into cryogenic liquid (SCFL) using poly vinyl pyrrolidone K-30 (PVP K-30); that three drug polymer ratio (1:1, 1:2, and 1:3), with three different volumes of feeding solution (50, 100, 150 mL), at three flow rates (10, 20, and 30 mL/min). The prepared formulations were evaluated for production yield, particle size, zeta potential, drug content, release rate, in vivo hypoglycemic activity, and bioavailability. All prepared formulations showed high production yield and drug content ranged between 91.1 ± 3.4% and 94.3 ± 1.8% and 95.1 ± 2.8% and 97.1 ± 2.5%, respectively. The mean particles size was ranged between 280 ± 62 nm and 520 ± 30 nm. The results of in vitro release study revealed significant enhancement in the solubility of prepared formulations compared with the pure drug. It was found that optimal formula showed a significant reduction in blood glucose levels in diabetic rats, and 1.79-fold enhancements in oral bioavailability compared with market tablets. Nanoparticle prepared by SCFL method is an encouraging formula for improving the solubility and the bioavailability of glimepiride.

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“…Then after suitable dilution the solution was assayed for drug content using UV spectrophotometer by determining the absorbance at 363nm using 0.1N NaOH as blank (21) . The percentage of drug content in the SD was measured by using the following equation (22) . rug content (%) = Actual amount of drug in solid dispersions Theoretical amount of drug in solid dispersions × 100…”

Section: Determination Of Drug Content Of the Prepared Sd Of MLXmentioning

confidence: 99%

Formulation and In-Vitro Evaluation of Meloxicam Solid Dispersion using Natural Polymers.

ALhassani¹,

Al-Khedairy²

2021

IJPS

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Meloxicam (MLX) is non-steroidal anti -inflammatory, poorly water soluble, highly permeable drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Solid dispersion (SD) is an effective technique for enhancing the solubility and dissolution rate of such drug. The present study aims to enhance the solubility and the dissolution rate of MLX by SD technique by solvent evaporation method using sodium alginate (SA), hyaluronic acid (HA), collagen and xyloglucan (XG) as gastro-protective hydrophilic natural polymers. Twelve formulas were prepared in different drug: polymer ratios and evaluated for their, percentage yield, drug content, water solubility, dissolution, crystal lattice using powder X-ray diffraction (PXRD) and studies and Fourier Transform Infrared Spectroscopy (FTIR) for determination the drug-polymer interaction. All the prepared showed improvement of drug solubility except that prepared with HA. The best result was obtained with formula SD1 (MLX: SA 1:1) that showed a high percentage yield (97), high drug content (97.4±0.05) and increase in solubility compared to solubility of pure MLX with improved dissolution rate. the PXRD study revealed the conversion of the drug to amorphous form without chemical interaction according to FTIR results

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Development and in-vitro evaluation of Furosemide Solid Dispersion using different Water Soluble Carriers

Cited by 7 publications

References 15 publications

Formulation and Evaluation of Solid Dispersion Tablets of Furosemide Using Polyvinylpyrrolidone K-30

Formulation and Evaluation of Solid Dispersion Tablets of Furosemide Using Polyvinylpyrrolidone K-30

Synthesized nano particles of glimepiride via spray freezing into cryogenic liquid: characterization, antidiabetic activity, and bioavailability

Formulation and In-Vitro Evaluation of Meloxicam Solid Dispersion using Natural Polymers.

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