Development and matching of binocular orientation preference in mouse V1

Bhaumik, Basabi; Shah, Nishal P.

doi:10.3389/fnsys.2014.00128

Cited by 7 publications

(8 citation statements)

References 97 publications

(191 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This order of excitement and inhibition within V1's laminar microcircuit suggests that cortico-cortical interactions mediate binocular suppression within V1, with each portion of the microcircuit playing a distinct role. These findings provide important new information for neuronal models of binocular processing (Bhaumik & Shah, 2014; Bridge & Cumming, 2008).…”

Section: Discussionmentioning

confidence: 74%

Temporal dynamics of binocular integration in primary visual cortex

et al. 2019

View full text Add to dashboard Cite

Whenever we open our eyes, our brain quickly integrates the two eyes' perspectives into a combined view. This process of binocular integration happens so rapidly that even incompatible stimuli are briefly fused before one eye's view is suppressed in favor of the other (binocular rivalry). The neuronal basis for this brief period of fusion during incompatible binocular stimulation is unclear. Neuroanatomically, the eyes provide two largely separate streams of information that are integrated into a binocular response by the primary visual cortex (V1). However, the temporal dynamics underlying the formation of this binocular response are largely unknown. To address this question, we examined the temporal profile of binocular responses in V1 of fixating monkeys. We found that V1 processes binocular stimuli in a dynamic sequence that comprises at least two distinct temporal phases. An initial transient phase is characterized by enhanced spiking responses for both compatible and incompatible binocular stimuli compared to monocular stimulation. This transient is followed by a sustained response that differed markedly between congruent and incongruent binocular stimulation. Specifically, incompatible binocular stimulation resulted in overall response reduction relative to monocular stimulation (binocular suppression). In contrast, responses to compatible stimuli were either suppressed or enhanced (binocular facilitation) depending on the neurons' ocularity (selectivity for one eye over the other) and laminar location. These results suggest that binocular integration in V1 occurs in at least two sequential steps that comprise initial additive combination of the two eyes' signals followed by widespread differentiation between binocular concordance and discordance.

show abstract

Section: Discussionmentioning

confidence: 74%

Temporal dynamics of binocular integration in primary visual cortex

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It has been proposed that the response of visual cortical neurons to the inputs from the two eyes need to be tuned to similar orientations to encode binocular disparity of stimulus phase1950, suggesting that impaired matching of binocular orientation preference induced by miR-132/212 deletion underlies the defective depth perception of mutants.…”

Section: Discussionmentioning

confidence: 99%

“…It is well-known that depth perception exploits multiple visual cues, however binocular cues, such as disparity, are known to be particularly important also in mice 49 . It has been proposed that the response of visual cortical neurons to the inputs from the two eyes need to be tuned to similar orientations to encode binocular disparity of stimulus phase 19 50 , suggesting that impaired matching of binocular orientation preference induced by miR-132/212 deletion underlies the defective depth perception of mutants.…”

Section: Discussionmentioning

confidence: 99%

Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception

et al. 2017

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are known to mediate post-transcriptional gene regulation, but their role in postnatal brain development is still poorly explored. We show that the expression of many miRNAs is dramatically regulated during functional maturation of the mouse visual cortex with miR-132/212 family being one of the top upregulated miRNAs. Age-downregulated transcripts are significantly enriched in miR-132/miR-212 putative targets and in genes upregulated in miR-132/212 null mice. At a functional level, miR-132/212 deletion affects development of receptive fields of cortical neurons determining a specific impairment of binocular matching of orientation preference, but leaving orientation and direction selectivity unaltered. This deficit is associated with reduced depth perception in the visual cliff test. Deletion of miR-132/212 from forebrain excitatory neurons replicates the binocular matching deficits. Thus, miR-132/212 family shapes the age-dependent transcriptome of the visual cortex during a specific developmental window resulting in maturation of binocular cortical cells and depth perception.

show abstract

“…Layer 2/3 excitatory neurons in the binocular region of V1 receive information from both the contralateral and ipsilateral eye via thalamocortical and intracortical inputs that are shaped during critical periods of experience‐dependent plasticity (Hooks & Chen, 2020). The matching of binocular orientation preference, in which neurons receiving binocular input alter their synaptic connections to align the orientation preference of both contralateral and ipsilateral eye responses, represents one key example of experience‐dependent plasticity (Antonini, Fagiolini, & Stryker, 1999; Bhaumik & Shah, 2014; Gu & Cang, 2016; Kara & Boyd, 2009; Tie et al, 2018; Wang, Sarnaik, & Cang, 2010). This refinement of binocular matching is dependent upon NMDA receptors acting as coincidence detectors of contra‐ and ipsilateral drive (Sawtell et al, 2003), and NMDA receptor stimulation is known to be affected by loss of GLT1 function (Aida et al, 2015; Aida, Ito, Takahashi, & Tanaka, 2012; Pinky et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Astrocyte glutamate uptake coordinates experience‐dependent, eye‐specific refinement in developing visual cortex

Sipe

Petravicz

Rikhye

et al. 2021

Glia

View full text Add to dashboard Cite

The uptake of glutamate by astrocytes actively shapes synaptic transmission, however its role in the development and plasticity of neuronal circuits remains poorly understood. The astrocytic glutamate transporter, GLT1 is the predominant source of glutamate clearance in the adult mouse cortex. Here, we examined the structural and functional development of the visual cortex in GLT1 heterozygous (HET) mice using two‐photon microscopy, immunohistochemistry and slice electrophysiology. We find that though eye‐specific thalamic axonal segregation is intact, binocular refinement in the primary visual cortex is disrupted. Eye‐specific responses to visual stimuli in GLT1 HET mice show altered binocular matching, with abnormally high responses to ipsilateral compared to contralateral eye stimulation and a greater mismatch between preferred orientation selectivity of ipsilateral and contralateral eye responses. Furthermore, we observe an increase in dendritic spine density in the basal dendrites of layer 2/3 excitatory neurons suggesting aberrant spine pruning. Monocular deprivation induces atypical ocular dominance plasticity in GLT1 HET mice, with an unusual depression of ipsilateral open eye responses; however, this change in ipsilateral responses correlates well with an upregulation of GLT1 protein following monocular deprivation. These results demonstrate that a key function of astrocytic GLT1 function during development is the experience‐dependent refinement of ipsilateral eye inputs relative to contralateral eye inputs in visual cortex.

show abstract

Development and matching of binocular orientation preference in mouse V1

Cited by 7 publications

References 97 publications

Temporal dynamics of binocular integration in primary visual cortex

Temporal dynamics of binocular integration in primary visual cortex

Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception

Astrocyte glutamate uptake coordinates experience‐dependent, eye‐specific refinement in developing visual cortex

Contact Info

Product

Resources

About