Development and maturation of natural killer cells

Geiger, Theresa L.; Sun, Joseph C.

doi:10.1016/j.coi.2016.01.007

Cited by 124 publications

(105 citation statements)

References 98 publications

(109 reference statements)

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“…Interestingly, NK cells are derived from a common lymphoid progenitor cell that develops into an NK cell precursor (NKP) and immature NK cells (iNK). As NK cells mature in the bone marrow (marked by the expression of CD11b, CD43, Ly49, CD49b), they gain functional competence in cytotoxicity and interferon gamma expression and egress from the bone marrow (for a review see [89]). Recent studies have suggested an important role for TAM signaling in NK cell differentiation and anti-tumor activity.…”

Section: Mechanisms Of Axl-mediated Tumor Progression and Metastasismentioning

confidence: 99%

The Receptor Tyrosine Kinase AXL in Cancer Progression

Rankin

Giaccia

2016

Cancers

141

102

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The AXL receptor tyrosine kinase (AXL) has emerged as a promising therapeutic target for cancer therapy. Recent studies have revealed a central role of AXL signaling in tumor proliferation, survival, stem cell phenotype, metastasis, and resistance to cancer therapy. Moreover, AXL is expressed within cellular components of the tumor microenvironment where AXL signaling contributes to the immunosuppressive and protumorigenic phenotypes. A variety of AXL inhibitors have been developed and are efficacious in preclinical studies. These agents offer new opportunities for therapeutic intervention in the prevention and treatment of advanced disease. Here we review the literature that has illuminated the cellular and molecular mechanisms by which AXL signaling promotes tumor progression and we will discuss the therapeutic potential of AXL inhibition for cancer therapy.

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Section: Mechanisms Of Axl-mediated Tumor Progression and Metastasismentioning

confidence: 99%

The Receptor Tyrosine Kinase AXL in Cancer Progression

Rankin

Giaccia

2016

Cancers

141

102

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“…Conventional NK cell development occurs primarily in the BM and progresses through several stages that can be demarcated by the expression of specific cell surface markers and transcription factors (Geiger and Sun, 2016; Sun and Lanier, 2011; Yokoyama et al, 2004). The NK cell progenitor (NKP), which is a CD122 + Lin − cell, gives rise to iNK cells, which express NK1.1 and T-bet.…”

Section: The Original View: Ilc1s As Ink Cellsmentioning

confidence: 99%

“…1). First, it should be emphasized that by the broadest definition of the term, NK cells are ILCs because they do not require RAG proteins and derive from the CLP (Geiger and Sun, 2016; Yokoyama et al, 2004). The discovery of the αLP, which gives rise to all ILC populations and NK cells but not T or B cells, further substantiates this view (Yu et al, 2014).…”

Section: Nk Cells and Ilc1s Belong To The Same Ilc Groupmentioning

confidence: 99%

Diversity and function of group 1 innate lymphoid cells

Cortez

Colonna

2016

Immunology Letters

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Innate lymphoid cells (ILCs) are a heterogeneous population of cells with diverse roles in immune responses. Three major groups of ILCs have been defined on the basis of similarity in their production of signature cytokines, developmental requirements, and phenotypic markers. Group 1 ILCs produce IFN-γ, express the T-box transcription factors (TF) Eomesodermin (Eomes) and/or T-bet. Group 2 ILCs secrete IL-5 and IL-13, express the TF GATA-3, and are identified by the expression of KLRG1, the receptor IL-7 (IL7R, also known as CD127), and the receptor for IL-33 (IL33R). Finally, group 3 ILCs produce IL-22 and IL-17 and express the TF RORγt along with the cell surface receptors CD127, NKp46, and CCR6. In this review, we will briefly overview each group in terms of phenotype, function and development and then focus more extensively on group 1 ILCs, expanding on their emerging diversity, their disparate functions and the differences between NK cells and ILC1.

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“…Most importantly, they lack the canonical antigen receptors which functionally define the mainline lymphoid lineages – the T cell or B cell antigen receptors (Artis and Spits, 2015). Having been subsumed into the ILC paradigm, NK cells can be considered the prototypic lineage for understanding ILC function (Geiger and Sun, 2016). ILC subsets are found in numerous compartments, but are relatively enriched at mucosal surfaces.…”

Section: Resultsmentioning

confidence: 99%

Regulation of autoimmune myocarditis by host responses to the microbiome

Barin

Talor

Diny

et al. 2017

Experimental and Molecular Pathology

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The extensive, diverse communities that constitute the microbiome are increasingly appreciated as important regulators of human health and disease through inflammatory, immune, and metabolic pathways. We sought to elucidate pathways by which microbiota contribute to inflammatory, autoimmune cardiac disease. We employed an animal model of experimental autoimmune myocarditis (EAM), which results in inflammatory and auto-immune pathophysiology and subsequent maladaptive cardiac remodeling and heart failure. Antibiotic dysbiosis protected mice from EAM and fibrotic cardiac dysfunction. Additionally, mice derived from different sources with different microbiome colonization profiles demonstrated variable susceptibility to disease. Unexpectedly, it did not track with segmented filamentous bacteria (SFB)-driven Th17 programming of CD4+ T cells in the steady-state gut. Instead, we found disease susceptibility to track with presence of type 3 innate lymphoid cells (ILC3s). Ablating ILCs by antibody depletion or genetic tools in adoptive transfer variants of the EAM model demonstrated that ILCs and microbiome profiles contributed to the induction of CCL20/CCR6-mediated inflammatory chemotaxis to the diseased heart. From these data, we conclude that sensing of the microbiome by ILCs is an important checkpoint in the development of inflammatory cardiac disease processes through their ability to elicit cardiotropic chemotaxis.

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Development and maturation of natural killer cells

Cited by 124 publications

References 98 publications

The Receptor Tyrosine Kinase AXL in Cancer Progression

The Receptor Tyrosine Kinase AXL in Cancer Progression

Diversity and function of group 1 innate lymphoid cells

Regulation of autoimmune myocarditis by host responses to the microbiome

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