Development and mechanical characterization of bilayer tubular scaffolds for vascular tissue engineering applications

Tran, Thanh Tam; Hamid, Zuratul Ain Abdul; Lai, Ngoc Thien; Cheong, Kuan Yew; Todo, Mitsugu

doi:10.1007/s10853-019-04159-3

Cited by 8 publications

(2 citation statements)

References 27 publications

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“…The values of k 1 and k 2 are expected to exhibit a direct relationship with the porosity and average pore size of the structure, as indicated by various empirical relationships documented in the existing literature. 27 However, the results of this study suggest that the relationship among porosity, pore size, and permeability was inconclusive. Specifically, the data presented in Table 2 for porosity, Figure 3 for pore size, and Figure 4 for permeability do not provide conclusive correlation evidence.…”

Section: Resultsmentioning

confidence: 64%

“…Furthermore, the silicon container had a low heat transfer coefficient, which slowed the rate of crystallization in relation to the mold's top. Tran et al 27 described a similar gradient microstructure obtained in freeze-drying methods. The gradient microarchitecture was obtained by dipping the precooled Teflon rod into the poly(L-lactide-co-ecaprolactone) solution, forcing an immediate freeze on the surface, followed by a gradual freezing of the solution on the top of the initial frozen layer.…”

Section: Resultsmentioning

confidence: 91%

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Microstructural, Fluid Dynamic, and Mechanical Characterization of Zinc Oxide and Magnesium Chloride-Modified Hydrogel Scaffolds

de Mello Innocentini,

Fuzatto Bueno,

Urbaś

et al. 2024

ACS Biomater. Sci. Eng.

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Scaffolds for the filling and regeneration of osteochondral defects are a current challenge in the biomaterials field, and solutions with greater functionality are still being sought. The novel approach of this work was to obtain scaffolds with biologically active additives possessing microstructural, permeability, and mechanical properties, mimicking the complexity of natural cartilage. Four types of scaffolds with a gelatin/alginate matrix modified with hydroxyapatite were obtained, and the relationship between the modifiers and substrate properties was evaluated. They differed in the type of second modifier used, which was hydrated MgCl 2 in two proportions, ZnO, and nanohydroxyapatite. The samples were obtained by freeze-drying by using two-stage freezing. Based on microstructural observations combined with X-ray microanalysis, the microstructure of the samples and the elemental content were assessed. Permeability and mechanical tests were also performed. The scaffolds exhibited a network of interconnected pores and complex microarchitecture, with lower porosity at the surface (15 ± 7 to 29 ± 6%) and higher porosity at the center (67 ± 8 to 75 ± 8%). The additives had varying effects on the pore sizes and permeabilities of the samples. ZnO yielded the most permeable scaffolds (5.92 × 10 −11 m 2 ), whereas nanohydroxyapatite yielded the scaffold with the lowest permeability (1.18 × 10 −11 m 2 ), values within the range reported for trabecular bone. The magnesium content had no statistically significant effect on the permeability. The best mechanical parameters were obtained for ZnO samples and those containing hydrated MgCl 2 . The scaffold's properties meet the criteria for filling osteochondral defects. The developed scaffolds follow a biomimetic approach in terms of hierarchical microarchitecture and mechanical parameters as well as chemical composition. The obtained composite materials have the potential as biomimetic scaffolds for the regeneration of osteochondral defects.

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Section: Resultsmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 91%