Development and Modulation of Female Reproductive Function by Circadian Signals

Gotlieb, Neta; Moeller, Jacob; Kriegsfeld, Lance J.

doi:10.1007/978-3-030-40002-6_16

Cited by 9 publications

(9 citation statements)

References 252 publications

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“…On the day of proestrus, before the peak in estradiol and progesterone levels, rats spend more time sleeping than any other estrous phase ( Colvin et al, 1968 ). Typically, estrogen peaks a few hours before dark phase onset and progesterone peaks early in the dark phase ( Smith et al, 1975 ; Gotlieb et al, 2020 ). During the night of proestrus, the amount of REM and NREM sleep is markedly reduced in female rats relative to the same time point in other phases of the estrous cycle ( Colvin et al, 1968 , 1969 ; Yamaoka, 1978 ; Kleinlogel, 1983 ; Fang and Fishbein, 1996 ; Schwierin et al, 1998 ; Hadjimarkou et al, 2008 ; Schwartz and Mong, 2013 ).…”

Section: Insights From Animal Modelsmentioning

confidence: 99%

Neurobiological and Hormonal Mechanisms Regulating Women’s Sleep

2021

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Sleep is crucial for optimal well-being, and sex differences in sleep quality have significant implications for women’s health. We review the current literature on sex differences in sleep, such as differences in objective and subjective sleep measures and their relationship with aging. We then discuss the convincing evidence for the role of ovarian hormones in regulating female sleep, and survey how these hormones act on a multitude of brain regions and neurochemicals to impact sleep. Lastly, we identify several important areas in need of future research to narrow the knowledge gap and improve the health of women and other understudied populations.

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Section: Insights From Animal Modelsmentioning

confidence: 99%

Neurobiological and Hormonal Mechanisms Regulating Women’s Sleep

2021

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“…2 ). Estradiol concentrations are low during diestrus but build to a peak by the afternoon of proestrus, which, in conjunction with a daily circadian signal, triggers ovulation ( 9 , 10 ). This is quickly followed by a sharp peak in progesterone produced by the corpus luteum, which declines by the following morning ( 11-13 ).…”

Section: The Hormonal Regulation Of Sexual Behaviormentioning

confidence: 99%

Neural and Hormonal Control of Sexual Behavior

Jennings

Lecea

2020

Endocrinology

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Gonadal hormones contribute to the sexual differentiation of brain and behavior throughout the lifespan, from initial neural patterning to ‘activation’ of adult circuits. Sexual behavior is an ideal system in which to investigate the mechanisms underlying hormonal activation of neural circuits. Sexual behavior is a hormonally regulated, innate social behavior found across species. Although both sexes seek out and engage in sexual behavior, the specific actions involved in mating are sexually dimorphic. Thus, the neural circuits mediating sexual motivation and behavior in males and females are overlapping yet distinct. Furthermore, sexual behavior is strongly dependent on circulating gonadal hormones in both sexes. There has been significant recent progress on elucidating how gonadal hormones modulate physiological properties within sexual behavior circuits with consequences for behavior. Therefore, in this mini-review we review the neural circuits of male and female sexual motivation and behavior from initial sensory detection of pheromones to the extended amygdala and on to medial hypothalamic nuclei and reward systems. We also discuss how gonadal hormones impact the physiology and functioning of each node within these circuits. By better understanding the myriad of ways in which gonadal hormones impact sexual behavior circuits, we can gain a richer and more complete appreciation for the neural substrates of complex behavior.

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“…Our study also supports the hypothesis that maternal body condition or energy balance contributes to changes in progesterone ( Wilsterman et al, 2018 ). Intriguingly, new data from this study suggest that stress exposure alters the daily pattern of corticosterone production (see Figures 5A,B ), perhaps pointing to effects of stress on the circadian system (e.g., Smarr et al, 2017 ; Varcoe, 2018 ; Gotlieb et al, 2020 ). More detailed work on markers of energy balance that may influence progesterone secretion and circadian dynamics related to stress responses during gestation are needed to disentangle the mechanisms driving this relationship.…”

Section: Discussionmentioning

confidence: 63%

Impact of Chronic Prenatal Stress on Maternal Neuroendocrine Function and Embryo and Placenta Development During Early-to-Mid-Pregnancy in Mice

et al. 2022

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Psychological stress, both leading up to and during pregnancy, is associated with increased risk for negative pregnancy outcomes. Although the neuroendocrine circuits that link the stress response to reduced sexual motivation and mating are well-described, the specific pathways by which stress negatively impacts gestational outcomes remain unclear. Using a mouse model of chronic psychological stress during pregnancy, we investigated 1) how chronic exposure to stress during gestation impacts maternal reproductive neuroendocrine circuitry, and 2) whether stress alters developmental outcomes for the fetus or placenta by mid-pregnancy. Focusing on the stress-responsive neuropeptide RFRP-3, we identified novel contacts between RFRP-3-immunoreactive (RFRP-3-ir) cells and tuberoinfundibular dopaminergic neurons in the arcuate nucleus, thus providing a potential pathway linking the neuroendocrine stress response directly to pituitary prolactin production and release. However, neither of these cell populations nor circulating levels of pituitary hormones were affected by chronic stress. Conversely, circulating levels of steroid hormones relevant to gestational outcomes (progesterone and corticosterone) were altered in chronically-stressed dams across gestation, and those dams were qualitatively more likely to experience delays in fetal development. Together, these findings suggest that, up until at least mid-pregnancy, mothers appear to be relatively resilient to the effects of elevated glucocorticoids on reproductive neuroendocrine system function. We conclude that understanding how chronic psychological stress impacts reproductive outcomes will require understanding individual susceptibility and identifying reliable neuroendocrine changes resulting from gestational stress.

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Development and Modulation of Female Reproductive Function by Circadian Signals

Cited by 9 publications

References 252 publications

Neurobiological and Hormonal Mechanisms Regulating Women’s Sleep

Neurobiological and Hormonal Mechanisms Regulating Women’s Sleep

Neural and Hormonal Control of Sexual Behavior

Impact of Chronic Prenatal Stress on Maternal Neuroendocrine Function and Embryo and Placenta Development During Early-to-Mid-Pregnancy in Mice

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