Development and molecular modeling of Co(II), Ni(II) and Cu(II) complexes as high acting anti breast cancer agents

Deodware, Sachin A.; Sathe, D.J.; Choudhari, Prafulla B.; Lokhande, Tukaram N.; Gaikwad, Shashikant H.

doi:10.1016/j.arabjc.2016.09.024

Cited by 22 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the magnetic moment values of the complexes prove that the coordination number of the complexes is five and they have square pyramidal geometry. 63…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterisation of novel Cu(ii)-anchored biopolymer complexes as reusable materials for the photocatalytic degradation of methylene blue

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Furthermore, the magnetic moment values of the complexes prove that the coordination number of the complexes is five and they have square pyramidal geometry. 63…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterisation of novel Cu(ii)-anchored biopolymer complexes as reusable materials for the photocatalytic degradation of methylene blue

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[54] Ahamed et al have shownt hat Ni/Fe NPs are able to cause selective and dose-dependent cytotoxicity in humanl iver (HepG2) and breast (MCF-7) cancer cells at ac oncentration above 5 mgmL À1 . [54] Ahamed et al have shownt hat Ni/Fe NPs are able to cause selective and dose-dependent cytotoxicity in humanl iver (HepG2) and breast (MCF-7) cancer cells at ac oncentration above 5 mgmL À1 .…”

Section: Pristine/alloyed Metal Npsmentioning

confidence: 99%

“…Besides Pt-based complexes, Ni II complexes are potential anti-cancer chemotherapeutic agents owing to their strong reactions with specific amino acids in cyclin-dependentk inases (CDK), which are crucial to cell-cycle and gene transcription regulation. [54] Ahamed et al have shownt hat Ni/Fe NPs are able to cause selective and dose-dependent cytotoxicity in humanl iver (HepG2) and breast (MCF-7) cancer cells at ac oncentration above 5 mgmL À1 . [25b] It is hypothesized that elevation of the intracellularo xidative stress, loss of the mitochondrial membrane potential (MMP), and alteration of apoptosisrelated genes and pathways account for Ni/Fe NPs-inducedc ytotoxicity in cancerous cells.…”

Section: Ru-mua@sementioning

confidence: 99%

See 1 more Smart Citation

Inherent Chemotherapeutic Anti‐Cancer Effects of Low‐Dimensional Nanomaterials

Zhou

Chu

et al. 2019

Chemistry A European J

View full text Add to dashboard Cite

Low-dimensional nanomaterials (LDNs) are receiving increasing attention in cancert herapy owing to their unique properties, especially the large surfacea rea-tovolume ratio. LDNs such as metallicn anoparticles (NPs), hydroxyapatite NPs, graphene derivatives, and black phosphorus (BP) nanosheets have been proposed for drug delivery, photothermal/photodynamic therapies, andm ultimodal theranostict reatments. The therapeutic effectiveness is mainly based on the physical characteristics of LDNs, but their inherent bioactivity has not been fully capitalized. In this Minireview,r ecent advances in the anti-cancer effects of varioust ypes of LDNs with inherentc hemotherapeutic bioactivity are described and the bioactivity mechanismsa re discussed on the cellular and molecular levels.B P, one of the newesta nd exciting members of the LDN family,i sh ighlighted owing to the excellent inherent bioactivity,s electivity,a nd biocompatibility in cancert herapy.L DNs and related derivatives possess inherentb ioactivity and selective chemotherapeutic effects suggesting large potentiala sn anostructured anti-cancer agentsinc ancer therapy.

show abstract

“…These constitute a ready-made building block for construction of various organic heterocycles. 21 Schiff bases and their metal complexes derived from 3-substituted-4-amino-5-mercapto-1, 2, 4-triazoles exhibit remarkable anti-breast cancer, antiinflammatory, analgesic, antidepressant, antimicrobial activities 22,23 and they are useful analytical reagents [24][25][26][27] . In view of medicinal and biological properties of 3-substituted-4-amino-5-mercapto-1, 2, 4-triazoles, substituted pyrazoles; we thought that the combination of these moieties would result in enhanced biological activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Schiff Base as Dna Gyrase B Inhibitor, Antibacterial, Anti-Inflammatory and Antioxidant Agents

Kate¹,

Gaikwad²,

Lokhande³

et al. 2018

RJC

View full text Add to dashboard Cite

A series of some 4-{[(Z)-(1,3-diphenyl-1H-pyrazole-4-yl)methylidene]amino}-5-methyl-4H-1,2,4-triazole-3-thiols were synthesized by reaction of substituted 1,3-diphenyl-1H-pyrazole-4-carbaldehyde with 4-amino-5-methyl-4H-1,2,4-triazole-3-thiol in acidic medium. The synthesized compounds were characterized by 1 H NMR, 13 C NMR, IR and mass spectroscopic techniques. The products were obtained in high yield and were screened for antiinflammatory, antioxidant and antibacterial activities against various pathogenic bacteria. Compound EP 8 (71.55%) and EP 10 (74.31 %) exhibited excellent anti-inflammatory activity while compound EP 5 (56.87 %) and EP 8 (52.50 %) exhibited good antioxidant activity. Molecular docking study exhibited the possible mode of action of synthesized derivatives by inhibition of DNA gyrase B.

show abstract

Development and molecular modeling of Co(II), Ni(II) and Cu(II) complexes as high acting anti breast cancer agents

Cited by 22 publications

References 19 publications

Synthesis and characterisation of novel Cu(ii)-anchored biopolymer complexes as reusable materials for the photocatalytic degradation of methylene blue

Synthesis and characterisation of novel Cu(ii)-anchored biopolymer complexes as reusable materials for the photocatalytic degradation of methylene blue

Inherent Chemotherapeutic Anti‐Cancer Effects of Low‐Dimensional Nanomaterials

Synthesis of Schiff Base as Dna Gyrase B Inhibitor, Antibacterial, Anti-Inflammatory and Antioxidant Agents

Contact Info

Product

Resources

About