Development and optimization of a rapid HPLC method for analysis of ricobendazole and albendazole sulfone in sheep plasma

Wu, Zimei; Medlicott, Natalie J.; Razzak, Majid; Tucker, Ian G.

doi:10.1016/j.jpba.2005.03.010

Cited by 39 publications

(33 citation statements)

References 23 publications

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“…Furthermore, ABZ is a potential anticancer agent that is currently under development for the treatment of cancer (Zhao et al, 2008), (Mohammad et al 2010) A major problem associated with the formulation and effectiveness of ABZ is its poor aqueous solubility, 0.61 μg/ml, which may account for its low and irregular bioavailability in humans (Wu et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Solubility improvement of an anthelmintic benzimidazole carbamate by association with dendrimers

Fernández

Sigal

Otero

et al. 2011

Braz. J. Chem. Eng.

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-The improvement of aqueous solubility of methyl (5-[propylthio]-1H-benzimidazol-2-yl) carbamate, albendazole (ABZ) using polyamidoamine (PAMAM) dendrimers as solubility enhancers was investigated. Full generation PAMAM dendrimers with amine terminal groups, (G3), with hydroxyl terminal groups (G3OH) and half generation PAMAM dendrimers with carboxylate terminal groups (G2.5 and G3.5), were chosen for this study. The nature of dendrimer-ABZ association was investigated by UV absorption, fluorescence emission measurements and by 1 H-NMR spectroscopy. The results obtained show that these polymeric structures have the capacity to enhance the solubility of ABZ, both lipophilic and specific hydrogen bond interactions contributing to the guest-host association. Although all studied dendrimers have hydrophobic internal nanoenvironments with similar dimensions, their surfaces differ significantly and the nature and the localization of the interactions involved in ABZ-dendrimer association depend on the type of terminal groups.

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Section: Introductionmentioning

confidence: 99%

Solubility improvement of an anthelmintic benzimidazole carbamate by association with dendrimers

Fernández

Sigal

Otero

et al. 2011

Braz. J. Chem. Eng.

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“…Evaluation and the determination of various pharmacokinetic parameters of ABZ and PRQ, the method has been developed which is simple, selective and sensitive analytical method for Limit of Quantitation [LOQ] determination in plasma samples for different metabolites. A number of High-performance liquid chromatographic [HPLC] system [20][21][22][23][24][25][26][27][28][29] and capillary electrophoresis methods [CE] [30][31] has been developed for the estimation of ABZ & PRQ. A recent advances method has been developed for the estimation of ABZ, ABZSO, ABZSO2 & PRQ in trans form by tandem mass spectrophotometry [LC-MS/MS].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of albendazole and praziquantel in rat plasma by HPLC-UV

Shah

Dey

Kant

et al. 2017

Proceedings of the 21st International Electronic Conference on Synthetic Organic Chemistry

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INTRODUCTIONThe most common helminthic disease of the nervous system is nee is the most common helminthic disease of the nervous system, is neurocysticercosis, which is considered as a serious public health problem in developing countries of Latin America, Asia and Africa [1][2][3]. The use of both the drugs Albendazole [ABZ] and Praziquantel [PRQ] consider an effective against the cystic larvae for the treatment of neurocysticercosis over the last 20 years with the use of both the drugs ABZ & PRQ. ABZ has been found an effective drug of choice than PRQ, but this persistence of cysts even after continuous use of ABZ [2]. For the patients, who were the persistence of cyst after the use of ABZ, an alternative treatment therapy was developed where there was simultaneous use of PRQ and ABZ has been evaluated [4][5]. Albendazole and Praziquantel in combination were used extensively for human hydatid disease [6][7][8][9]. Albendazole [ABZ] is an inactive moiety but it readily gets metabolized to an active metabolite Albendazole sulfoxide [ABZSO] then this ABZSO is then further metabolized to an inactive metabolite Albendazole sulfone [ABZSO2] [10]. As ABZ is metabolized extensively, therefore, the plasma concentration of ABZ is also very low as a result the pharmacokinetic studies were been done using Albendazole sulfoxide [ABZSO] as an active metabolite and Albendazole sulfone [ABZSO2] as an inactive metabolite [11][12][13][14][15]. Metabolism of Praziquantel [PRQ] occurs giving a number of hydroxylated metabolites [16][17][18], among which the active metabolite is mainly trans-4-hydroxypraziquantel [TRANS], an active metabolite [19]. Evaluation and the determination of various pharmacokinetic parameters of ABZ and PRQ, the method has been developed

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“…Therefore, a new method is researched and developed for the determination of MBZ, ABZ, and FBZ, which is of great importance in physiology and clinical applications. Some methods have been reported for the analysis of MBZ, ABZ, and FBZ, for instance, liquid chromatography (LC) [6][7][8], high performance liquid chromatography (HPLC) [4,9], liquid chromatography-mass spectrometry (LC-MS) [10], capillary electrophoresis-mass spectrometry (CE-MS) [11], UHPLC-MS [12,13], and so on. Although some methods detect low concentration, some inherent issues cannot be avoided effectively, such as complicated pretreatment and operation, expensive apparatus, and complex probe preparation.…”

Section: Introductionmentioning

confidence: 99%

Study on the interaction between three benzimidazole anthelmintics and eosin Y by high performance liquid chromatography associating with resonance light scattering and its application

et al. 2016

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A novel, highly selective, and sensitive resonance light scattering (RLS) detection approach coupled with high performance liquid chromatography (HPLC) was researched and developed for the synchronous analysis of three kinds of benzimidazole anthelmintics, including mebendazole (MBZ), albendazole (ABZ), and fenbendazole (FBZ) for the first time. In the pH range of 3.5-3.7 Britton-Robinson buffer medium, three kinds of anthelmintics, which were separated by HPLC, reacted with eosin Y (EY) to form 1:1 ion-association complexes, resulting in significantly enhanced RLS signals and the maximum peak located at 335 nm. The enhanced RLS intensity was in proportion to the MBZ, ABZ, and FBZ concentration in the range 0.2-25, 0.2-23, and 0.15-20 μg/mL, respectively. The limit of detection was in the range of 0.064-0.16 μg/mL. In addition, human urine was determined to validate the proposed method by spiked samples and real urine samples. Satisfactory results were obtained by HPLC-RLS method. Graphical Abstract The diagram mechanism of generating resonance between emitted light and scattered light.

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Development and optimization of a rapid HPLC method for analysis of ricobendazole and albendazole sulfone in sheep plasma

Cited by 39 publications

References 23 publications

Solubility improvement of an anthelmintic benzimidazole carbamate by association with dendrimers

Solubility improvement of an anthelmintic benzimidazole carbamate by association with dendrimers

Simultaneous determination of albendazole and praziquantel in rat plasma by HPLC-UV

Study on the interaction between three benzimidazole anthelmintics and eosin Y by high performance liquid chromatography associating with resonance light scattering and its application

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